Impotence after prostate cancer treatment

According to researchers patients undergoing treatment for prostate cancer could be at a risk of impotence. According to the new study, published in the Journal of the American Medical Association there may be a formula to help gauge those risks for three common types of treatment, including surgery and radiation.

One expert called the findings “a major step forward,” but also warned patients and doctors not to use the results to choose between different types of treatment. “It's really at this stage for the patient who has made up his mind that he's going to have surgery or radiation and then asks, What can I expect?” said Dr. Philipp Dahm, a urologist from the University of Florida in Gainesville who wasn't part of the study. “This will give you a very good answer,” he said.

According to the American Cancer Society, one in six men gets prostate cancer at some point in his life, and one in 36 dies from the disease. There is controversy over how to treat low-risk tumors, which often don't cause any harm if left untreated. But when the disease is more advanced, surgery and radiation are common options. This year, for instance, about 90,000 Americans will undergo radical prostatectomy, a procedure in which the entire prostate is removed. They face common side effects such as impotence and incontinence during routine activities, and urologists have recently learned that some may also leak urine during sex.

The men were enrolled in the Prostate Cancer Outcomes and Satisfaction With Treatment Quality Assessment (PROSTQA). For this latest study researchers used data from 1,027 men treated for prostate cancer at different hospitals across the country. All of the participants answered questions about their sex life before being treated with prostate surgery, external radiation or radioactive “seeds” implanted in the prostate.

More than a quarter of the men said they were impotent before they were treated. Of those who weren't, 52 percent reported new erectile problems two years after their treatment. In the surgery group, 60 percent of men who used to have a good sex life said they had become impotent. That figure was 42 percent among patients who received external radiation and 37 percent among those who had seeds implanted.

However, the chance of sexual problems varied a lot, depending on factors like age, race, weight, prior sexual function, blood levels of prostate specific antigen (PSA), hormone treatment and the specific kind of surgery.

For a normal-weight, 60-year-old African American with a good sex life, the chance that he would lose his ability to get an erection after having seeds implanted was only two percent, for example. An extremely obese 70-year-old white man getting the same therapy would have a 58-percent risk of becoming impotent.

“Sexual function is one of the things that are most commonly affected by prostate cancer treatment,” said. Dr. Martin G. Sanda, who heads the Prostate Center at Beth Israel Deaconess Medical Center in Boston and led the new study. “Putting these formulas out there is really step one,” he said. “Up to now there hasn't been something like this out there for side effects from prostate cancer treatment.”

The next step is to make the formulas easily available, for instance as a web tool, and expand them to other side effects such as incontinence, Sanda added. He said the information necessary to calculate a man's risk isn't hard to get, and filling out the questionnaire would only take minutes.

“In general for the surgical treatment the error bars might be a little broader, as much as 20 or 30 percent, than for some of the radiation groups,” Sanda said. “There is some variability, meaning there are some things that influence the outcome that may not be accounted for in the models.”

In an editorial, Dr. Michael J. Barry of Massachusetts General Hospital in Boston notes that the new formulas have some important limitations. “First, this study is observational, and patients should use the findings cautiously to help choose among treatments,” he writes. Barry also notes that a wait-and-see approach, instead of rushing to treatment, might in fact be the best way to minimize the risk of side effects while maximizing survival chances.

Other experts also pointed out limitations. For example the study didn’t include men who chose what’s called “active surveillance,” where a doctor keeps track of a tumor through regular tests and treats it only if the cancer markedly worsens. Many prostate cancer patients with slow-growing tumors can live their whole lives without symptoms or treatment, said Dr. Durado Brooks, prostate cancer director for the American Cancer Society. They die of something else before the cancer kills them.

“There are a lot of prostate cancers that are not likely to benefit from treatment,” Brooks said. Including an active surveillance group would have shown how much sexual function changes because of factors other than treatment, such as age and general health, he said. Most patients treated for early-stage prostate cancer survive, so the common side effects of treatment — incontinence and sexual problems — have become more important for patients making choices.

The study was done from 2003 through 2006, a time when laparoscopic surgery, with small incisions and often performed robotically, was less common than it is today. “This paper gives us one piece of the puzzle,” said Barry. “It doesn’t address what are my chances with problems of incontinence? Or what are my chances of dying of prostate cancer for these different treatments? A patient would want to synthesize all that information to figure out what to do.”

Strength of the new study, Barry added, is that the researchers looked at men treated at nine different hospitals. If doctors use the approach, he said, it will give men an idea of what to expect based on their characteristics. He agreed with the researchers that the prediction model is best used after a man has chosen a treatment.

Dr. Ananya Mandal

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Dr. Ananya Mandal

Dr. Ananya Mandal is a doctor by profession, lecturer by vocation and a medical writer by passion. She specialized in Clinical Pharmacology after her bachelor's (MBBS). For her, health communication is not just writing complicated reviews for professionals but making medical knowledge understandable and available to the general public as well.

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Comments

  1. Cathrine Cathrine United States says:

    Under normal circumstances when you start to get an erection blood will flow into the chambers of the penis. While aroused, the body does not allow blood to flow out of the penis. However after you receive prostate cancer treatment this process may no longer function appropriately. When damage has been done to the veins or nerve pathways to the penis, you are not able to experience an erection.

  2. AustinScott AustinScott United States says:

    The ratio of cases of ED post treatment to prostate cancer varies widely across the globe. The percentage is as high as 60% getting impotent after the treatment of the cancer, though in some cases recovery from ED can occur after 18 month of the treatment. Though prostate cancer patients are properly counseled before undergoing to the treatment about the possible side-effects like ED, Impotence, etc .But after the surgery most of them seem to be very disappointed as if they did not hear when they were counseled about the disease. In some cases prostate cancer was also treated by hormonal therapy which also leads to impotence and incontinence but usually this decision is taken by the physician depending on the case.

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
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