Avraham raises $3M to advance ladostigil Phase II Alzheimer's trial

The drug, ladostigil, is a molecule that combines components from the existing drugs Azilect and Exelon. Teva's Azilect, for the treatment of Parkinson's disease, was developed by Prof. Emeritus Moussa Youdim of the Technion-Israel Institute of Technology. Azilect is the only anti-Parkinson's drug that has proven to have a disease-modifying effect. Novartis's Exelon was developed by Prof. Marta Weinstock-Rosin of Hebrew University to treat Alzheimer's disease.

Ladostigil is the first Alzheimer's drug with the potential to slow the progression of clinical symptoms for sustained periods of time, and to modify the pathology associated with the disease. In addition, studies of ageing rats have shown that the drug may be able to slow the progression to Alzheimer's disease in patients diagnosed with MCI. It may also help treat mild cognitive impairment (MCI) and other neurodegenerative diseases.

TRDF was joined in this latest round of fund-raising by Yissum Research Development Company Ltd., the technology transfer arm of the Hebrew University; Pontifax, a venture capital investor focusing on Israeli life sciences; and Clal Biotechnology Industries (CBI). Avraham Pharmaceuticals intends to use the $3 million to continue to advance its on-going Phase II proof-of-concept trial of ladostigil in patients with Alzheimer's disease, and to begin a 36-month study to evaluate the safety and efficacy of ladostigil in patients diagnosed with MCI. This second study is expected to begin in the first quarter of 2012.

"Avraham greatly appreciates the continued support of all its investors, which has enabled the company to advance development of both its Alzheimer's disease-and MCI-directed drug products," said Dr. Vincent R. Zurawski, CEO of Avraham Pharmaceuticals.

Source:

Avraham Pharmaceuticals

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