Paul Allen pledges $300 million to better understand the brain’s inner workings

Microsoft co-founder and billionaire Paul Allen is donating $300 million to his Allen Institute for Brain Science to fund new projects to map and observe the human brain and, in Allen’s words, “to one day understand the essence of what makes us human.” That brings the total amount Allen has invested in the Institute to half a billion.

The announcement was made at a press conference today in Seattle and in a commentary in Nature, written by Christof Koch, the Institute’s Chief Scientific Officer, and R. Clay Reid of Harvard Medical School.

They lay out a way of doing brain research that involves optogenetics, a kind of deep stimulation of the brain using light, connectomics, the study of connections in the brain, and brain observatories, ways of monitoring what happens in the brain in real time. Right now, because the mouse is smaller and simpler, much of the early efforts focus on the mouse brain. One of Allen’s new efforts is to map the visual connections between the brain and the mouse. Mice have perhaps 2 million neurons involved in vision, compared to 5 billion such cells for humans.

“If you start out as a programmer, as I did in high school, the brain works in a completely different fashion than computers do,” Allen said, calling the effort “fascinating” and “noting that he’s been touched by neurodegenerative diseases” — his mother has Alzheimer’s. On the call he noted that while it’s possible to teach a student — a human brain — to program a computer in a matter of years, a computer can’t learn to function like a human brain even given a lifetime of opportunity. “”You can’t create an artificial intelligence,” Allen said, “unless you know how the real thing works.”

Allen said the goal is to create open science at an industrial scale. The institute says that every month 50,000 scientists access its brain map data. “We know that such an expensive project will have critics,” Koch and Reid write.  “The resources required could fund hundreds of other projects, so why focus them in this way? Our response is that funding agencies are already spending billions of dollars on many smaller projects across all areas of biomedical research, and the Allen Institute wants to pioneer a new approach. We want to understand one piece of brain tissue by integrating knowledge across techniques and scales, rather than distributing the funds more widely.”

Ed Boyden, an associate professor at the MIT Media Lab who is one of the pioneers in the field of optogenetics, wrote via Facebook chat, “The Allen Institute is assembling an extraordinary set of tools to tackle brain circuitry in a vertically integrated way, from the parts lists to how they all work together. It is impossible for an ordinary lab group to bring all these pieces together.”

The institute plans to double its staff to 350 employees over the next four years. Allen has given more than a billion dollars to various nonprofits over the past 20 years.

Dr. Ananya Mandal

Written by

Dr. Ananya Mandal

Dr. Ananya Mandal is a doctor by profession, lecturer by vocation and a medical writer by passion. She specialized in Clinical Pharmacology after her bachelor's (MBBS). For her, health communication is not just writing complicated reviews for professionals but making medical knowledge understandable and available to the general public as well.

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