Apelin-12 levels increased in childhood asthma

Children with asthma demonstrate significantly increased serum levels of the adipokine apelin-12, researchers report.

Furthermore, increased levels of apelin-12, which is expressed and secreted by adipocytes, were observed in both obese and normal-weight children with asthma.

The findings, published in Respiratory Medicine, suggest that "this adipokine may be implicated in the pathogenesis of childhood atopic asthma," say Alicja Kasperska-Zajac (Medical University of Silesia, Katowice, Poland) and team.

The researchers studied 89 children (61 boys), aged 7-17 years, with atopic asthma and 33 age- and gender-matched children without the condition.

Of the children with asthma, 30 (21 boys and nine girls) were obese, with a mean body mass index (BMI) of 24.6 kg/m2, and 59 (19 girls and 40 boys) were of normal weight, with a mean BMI of 18.3 kg/m2. All of the control children were of normal weight, with a mean BMI 18.3 kg/m2.

Using enzyme-linked immunosorbent assay, the team found that obese and normal-weight boys with asthma had significantly higher serum apelin-12 concentrations than control boys, at 167.8 and 163.9 versus 124.8 pg/mL, respectively.

Similarly, serum apelin-12 levels were significantly higher among obese and normal-weight girls with asthma compared with controls girls, at 188.9 and 186.2 versus 134.4 pg/mL, respectively.

Mean apelin-12 levels in girls with asthma were significantly higher than in boys with asthma. In the control group, there were no significant gender differences in apelin-12 levels.

There was no linear correlation between apelin-12 levels and BMI or BMI-standard deviation score among all the children. In those with asthma, apelin-12 did not relate to asthma severity, lung function measurements (spirometry), or degree of allergic sensitization.

Kasperska-Zajac et al conclude: "These findings suggest the potential association between apelin and atopic asthma.

"However, apelin -12 has limited value as potential biomarker in estimation of atopic asthma severity and degree of allergic sensitization."

They add: "Although this was a cross-sectional study with a relatively small sample size, we believe that our data may be a basis for further studies evaluating the possible role of adipokines in childhood atopic asthma pathogenesis."

Licensed from medwireNews with permission from Springer Healthcare Ltd. ©Springer Healthcare Ltd. All rights reserved. Neither of these parties endorse or recommend any commercial products, services, or equipment.

Advertisement

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News-Medical.Net.
Post a new comment
Post
You might also like... ×
Wayne State awarded NIH grant to improve outcomes, care for African American adolescents with asthma