Castle Biosciences launches MyUvealMelanoma website

Castle Biosciences Inc., a leading developer of prognostic tests for rare cancers, announced today the launch of, a website created to educate newly diagnosed patients, their families and healthcare providers about the most common form of eye cancer. MyUvealMelanoma tells the story of this disease, its treatment and the importance of prognostic testing, through the experience of patients who recently faced this devastating diagnosis first-hand. The site can be found at

As with many cancer diagnoses, one of the most urgent questions for doctors and patients is whether the disease has spread, or metastasized, to other parts of the body. This is especially critical with uveal melanoma since approximately half of these patients' eye cancer will ultimately spread to the liver, a development that is usually fatal. provides details on treating the primary eye tumor, and on predictive genomic testing to identify high-risk patients whose cancer is likely to spread in subsequent years.

The gene-expression profile test predicts a patient's metastatic risk by analyzing their eye tumor's molecular signature. The test, called DecisionDx-UM, was discovered in the early 2000s by Dr. J. William Harbour , a pioneering ocular oncologist and retina surgeon, and has since become standard of care in the management of eye cancer for the majority of ocular oncology practices.

Peter Leeflang , one of the patients featured on, spoke about the importance of knowing his risk of metastasis. "Even if it was a worst case scenario, I wanted to know so I could get my life in order. For me, knowing my risk counted big time. It sits in one's mind all the time if you don't know." Peter was diagnosed with uveal melanoma in early 2012 and said he was relieved to learn through gene expression testing that his tumor type is less likely to metastasize.

"Since only about 2-4% of patients have detectable metastatic disease at the time their primary uveal melanoma tumor is diagnosed, it is vitally important to have an accurate prognostic tool that identifies patients at high risk of the cancer spreading," said Dr. Harbour, Professor of Ophthalmology, Vice Chairman for Translational Research and Director of the Ocular Oncology Service at the Bascom Palmer Eye Institute in Miami. "Understanding one's individual risk helps guide further monitoring and treatment plans." carries the urgent message for newly diagnosed patients that testing must be performed prior to radiation treatment – the most common form of treatment for the primary eye tumor. Doctors planning to test usually take a small sample of the tumor just prior to removing it surgically and treating the area with radiation.   

"The most critical moment for any cancer patient is at the time of diagnosis," said Derek Maetzold , CEO of Castle Biosciences. "In the case of uveal melanoma, testing needs to be performed prior to eye treatment to determine whether the tumor type is likely to have spread beyond the eye.

"Our goal with is to inform newly diagnosed patients and their families of everything they need to know about their disease, including the availability of prognostic testing so that, with the help of their doctor, they can determine the best and most appropriate follow-up care."


Castle Biosciences Inc.


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