Cyclenium Pharma signs drug discovery and development agreement with Southern Research Institute

Cyclenium Pharma Inc., an emerging pharmaceutical company specializing in the research and development of novel drug candidates based on proprietary macrocyclic chemistry, today announced the signing of a discovery and co-development agreement with Southern Research Institute, a not-for-profit 501(c)(3) scientific research organization founded in 1941. The collaboration will utilize Cyclenium's proprietary libraries of next generation macrocyclic molecules and associated hit-to-lead optimization expertise in combination with Southern Research's extensive capabilities in target screening, compound profiling and preclinical development. The goal is to discover and jointly develop new clinical candidates for the treatment of cancer, infectious diseases and neurological conditions.

"We are very pleased to have initiated this collaboration with a prestigious organization like Southern Research," stated Helmut Thomas, Ph.D., President & CEO of Cyclenium. "Their breadth of expertise and long history of successful contributions to drug discovery and development will provide strong synergy for our proprietary macrocyclic technology with the expectation of multiple novel candidates resulting from our joint efforts over the next few years."

"Cyclenium's proprietary macrocyclic libraries are well suited for use against many of the challenging targets we are currently working on," stated Mark J. Suto, Ph.D. Vice-President Drug Discovery Division Southern Research Institute. "For example, screening of currently available small molecule libraries has not been very successful in the identification of new antibiotics and in targets associated with disrupting protein-protein interactions. The Cyclenium macrocycle libraries are unique in that they combine the complexities found in natural products with the drug-like properties needed for successful drug discovery. We are looking forward to collaborating with Cyclenium in the identification of new therapeutics."