Anxiety and déjà vu: an interview with Dr Christine Wells, Sheffield Hallam University

Dr. Christine WellsTHOUGHT LEADERS SERIES...insight from the world’s leading experts

What is currently known about how and why déjà vu happens?

It’s thought that the neural basis of déjà vu is located in the temporal lobes, a region of the brain strongly associated with the storage and retrieval of memories. One source of support for this is evidence from individuals with temporal lobe epilepsy, some of whom experience déjà vu episodes as part of seizure-related auras.

It is unclear as to why non-TLE déjà vu experiences occur, but what we do know is that occasional occurrences of this feeling are reported by a considerable proportion of the population.

Psychologists tend to think of it as a memory failure of sorts – we experience novelty accompanied by an erroneous sense of familiarity.

Please can you outline the theory that déjà vu is a result of a mistimed firing of neurons causing a temporary glitch in the processing of incoming information in the brain?

Whilst it is difficult to study (due to its usually transient nature), it has been suggested that the inappropriate feelings of familiarity which are characteristic of deja experiences are due to neurons in the temporal lobes.

The hippocampus and surrounding structures, located in the temporal lobes, are heavily involved in the encoding and recall of memories. It is thought that déjà vu experiences may be linked to neurons misinterpreting novelty as familiarity/an experience which has previously been encoded.

What are the main conditions persistent déjà vu has previously been associated with?

There have been a few case studies which have reported persistent déjà vu, some of which have been linked to forms of dementia.

It was recently reported that a man may have experienced déjà vu stemming from anxiety. Please can you give an overview of the report published by the Journal of Medical Case Reports?

The report focuses on a young man who reported a period of continuous déjà vu. Whilst he underwent neurological examinations, there was no clear indication from these tests that the déjà vu was linked to epilepsy.

The absence of a clear neurological cause led us to consider that it may be psychogenic in nature, and possibly linked to anxiety.

In what ways did the subject’s symptoms differ from previous cases?

He had insight into the fact that these were déjà vu experiences. Previous cases, such as mentioned above, are different in that those individuals tend to be unaware that they are experiencing déjà vu – instead they believe they have watched the programme on tv, seen the news already etc.

Does this case on its own prove that there’s a link between anxiety and déjà vu?

No it doesn’t, but it leads to some further interesting questions regarding the occurrence of déjà vu in relation to anxiety.

What further research is needed to investigate a possible link between clinical anxiety and episodes of déjà vu?

A more systematic study comparing the déjà vu experiences of individuals with and without anxiety.

Where can readers find more information?

The journal of medical case reports article (open access).

About Dr Christine Wells

I obtained by undergraduate degree in Psychology in 2006, and my PhD in Behavioural Neuroscience in 2010.

My research has focused on the role of the hippocampus in relation to anxiety and novelty detection, and I am also interested in the relationship between emotion and memory. I have been a lecturer in psychology at Sheffield Hallam since 2013.

April Cashin-Garbutt

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April Cashin-Garbutt

April graduated with a first-class honours degree in Natural Sciences from Pembroke College, University of Cambridge. During her time as Editor-in-Chief, News-Medical (2012-2017), she kickstarted the content production process and helped to grow the website readership to over 60 million visitors per year. Through interviewing global thought leaders in medicine and life sciences, including Nobel laureates, April developed a passion for neuroscience and now works at the Sainsbury Wellcome Centre for Neural Circuits and Behaviour, located within UCL.


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  1. Art Funkhouser Art Funkhouser Switzerland says:

    I think it should be said that there are many forms of déjà experience and each may well have it’s own cause. Many report that their déjà experiences arise from dreams that suddenly come true. Others say that they have gone to a place they know that they have never been before but they nevertheless know their way around. Some claim to know what is going to happen before it does because they have been through this experience before (while at the same time knowing this is impossible).

  2. Christine Ann Christine Ann United States says:

    Actually I know ... things are being covered up here.   I'm living a real life groundhog day longer than 8 times.    its real... physically real.   Deja vu etc is a warning don't follow it.  If u follow the timeline you will repeat it.    this effect for me is longer than a day.

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
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