Aggressive blood pressure treatment can reduce risks of heart disease and death

Loyola University Chicago is among the centers participating in a landmark clinical trial that has found that more intensive management of high blood pressure reduces heart disease rates and saves lives.

The trial included adults 50 years and older with high blood pressure. It found that adjusting blood pressure medications to achieve a target top number of 120 millimeters of mercury (mm Hg) reduced rates of cardiovascular events by almost a third, and the risk of death by almost a quarter, compared with targeting a top number of 140 mm Hg. (Cardiovascular events include heart attack, heart failure and stroke.)

Loyola University Medical Center enrolled 89 patients in the National Institutes of Health study, called the Systolic Blood Pressure Intervention Trial (SPRINT). Initial results were announced Sept. 11.

"This is the first clinical trial to confirm that a more intensive blood pressure regimen improves cardiovascular outcomes," said Holly Kramer, MD, principal investigator at the Loyola site, along with co-investigator Vinod K. Bansal, MD. Dr. Kramer is an associate professor in the Department of Public Health Sciences and Division of Nephrology and Dr. Bansal is a professor in the Division of Nephrology of Loyola University Chicago Stritch School of Medicine.

Gary H. Gibbons, MD, director of the National Heart, Lung, and Blood Institute, the primary sponsor of SPRINT, said: "The study provides potentially lifesaving information that will be useful to health care providers as they consider the best treatment options for some of their patients, particularly those over age 50. We are delighted to have achieved this important milestone in the study in advance of the expected closure date for the SPRINT trial and look forward to quickly communicating the results to help inform patient care and the future development of evidence-based clinical guidelines."

High blood pressure, or hypertension, is a leading risk factor for heart disease, stroke, kidney failure and other health problems. An estimated 1 in 3 people in the United States has high blood pressure.

The SPRINT study evaluates the benefits of maintaining a new target for systolic blood pressure, the top number in a blood pressure reading, among a group of patients 50 years and older at increased risk for heart disease or who have kidney disease. A systolic pressure of 120 mm Hg, maintained by this more intensive blood pressure intervention, could ultimately help save lives among adults age 50 and older who have a combination of high blood pressure and at least one additional risk factor for heart disease, the investigators say.

The SPRINT study, which began in the fall of 2009, includes more than 9,300 participants from about 100 medical centers and clinical practices throughout the United States and Puerto Rico. It is the largest study of its kind to examine how maintaining systolic blood pressure at a lower than currently recommended level will affect cardiovascular and kidney diseases. NIH stopped the blood pressure intervention earlier than originally planned in order to quickly disseminate the significant preliminary results.

The study population was diverse and included women, racial/ethnic minorities, and the elderly. The investigators point out that the SPRINT study did not include patients with diabetes, prior stroke, or polycystic kidney disease, as other research included those populations.

When SPRINT was designed, the well-established clinical guidelines recommended a systolic blood pressure of less than 140 mm Hg for healthy adults and 130 mm Hg for adults with kidney disease or diabetes. Investigators designed SPRINT to determine the potential benefits of achieving systolic blood pressure of less than 120 mm Hg.

Between 2010 and 2013, the SPRINT investigators randomly divided the study participants into two groups that differed according to targeted levels of blood pressure control. The standard group received blood pressure medications to achieve a target of less than 140 mm Hg. They received an average of two different blood pressure medications. The intensive treatment group received medications to achieve a target of less than 120 mm Hg and received an average of three medications.


Loyola University Health System


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