Scientists grow womb lining models that could shed light on early pregnancy events

Scientists from the University of Cambridge have grown miniature functional models of the womb lining in culture, representing a major step forwards in the study of early-stage pregnancy and conditions such as endometriosis.

Endometrial tissue 3d illustration © sciencepics / Shutterstock.com

Findings from the research, which was funded by the Medical Research Council, the Wellcome Trust and the Centre for Trophoblast Research have been published in Nature Cell Biology.

Margherita Turco and team grew the models, referred to as “organoids,” from endometrium-derived cells, which they then maintained in culture for a number of months. This enabled them to show that the organoids respond to female sex hormones and signals generated during early pregnancy, by secreting “uterine proteins,” which supply the embryo with essential nutrients during the first months of pregnancy.

“These organoids provide a major step forward in investigating the changes that occur during the menstrual cycle and events during early pregnancy when the placenta is established,” explains Turco. “These events are impossible to capture in a woman, so until now we have had to rely on animal studies.”

Previous studies of animal models have demonstrated that factors secreted by endometrial glands are essential in enabling a fertilized egg (referred to as the “conceptus") to implant itself in the womb lining.

Evidence also suggests that the conceptus sends signals to the endometrial glands, that then stimulate growth of the placenta. Using this “communication,” the conceptus therefore essentially stimulates its own development, failure of which would result in either a loss of pregnancy or severely restricted growth of the fetus.

The authors believe that having these organoids will provide important insight into this dialogue between the conceptus and the endometrial glands, potentially enabling them to establish whether parts of this process are faulty in women struggling to conceive. This could lead to the development of new therapies for such women.

Events in early pregnancy lay the foundations for a successful birth, and our new technique should provide a window into [these] events… There’s increasing evidence that complications of pregnancy, such as restricted growth of the fetus, stillbirth and pre-eclampsia – which appear later in pregnancy – have their origins around the time of implantation, when the placenta begins to develop.”

Graham Burton, Director of the Centre for Trophoblast Research and joint senior author of the paper

Furthermore, these organoids could also be grown from endometrial cancer cells to provide a model for the study of endometrial cancer. Similarly, models could be grown to enable investigation of other endometrial diseases such as endometriosis.

Sally Robertson

Written by

Sally Robertson

Sally has a Bachelor's Degree in Biomedical Sciences (B.Sc.). She is a specialist in reviewing and summarising the latest findings across all areas of medicine covered in major, high-impact, world-leading international medical journals, international press conferences and bulletins from governmental agencies and regulatory bodies. At News-Medical, Sally generates daily news features, life science articles and interview coverage.

Citations

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Robertson, Sally. (2019, June 17). Scientists grow womb lining models that could shed light on early pregnancy events. News-Medical. Retrieved on August 24, 2019 from https://www.news-medical.net/news/20170411/Scientists-grow-womb-lining-models-that-could-shed-light-on-early-pregnancy-events.aspx.

  • MLA

    Robertson, Sally. "Scientists grow womb lining models that could shed light on early pregnancy events". News-Medical. 24 August 2019. <https://www.news-medical.net/news/20170411/Scientists-grow-womb-lining-models-that-could-shed-light-on-early-pregnancy-events.aspx>.

  • Chicago

    Robertson, Sally. "Scientists grow womb lining models that could shed light on early pregnancy events". News-Medical. https://www.news-medical.net/news/20170411/Scientists-grow-womb-lining-models-that-could-shed-light-on-early-pregnancy-events.aspx. (accessed August 24, 2019).

  • Harvard

    Robertson, Sally. 2019. Scientists grow womb lining models that could shed light on early pregnancy events. News-Medical, viewed 24 August 2019, https://www.news-medical.net/news/20170411/Scientists-grow-womb-lining-models-that-could-shed-light-on-early-pregnancy-events.aspx.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News-Medical.Net.
Post a new comment
Post
You might also like... ×
Pregnancy-related widening of abdominal muscles may affect 'tummy tuck' outcomes