Study reviews accuracy, benefits, limitations of apps used for skin cancer diagnosis

In the scramble to bring successful apps for the diagnosis of skin cancer to market there is a concern that a lack of testing is risking public safety, according to research led by the University of Birmingham.

The research, outlined at the British Association of Dermatologists' Annual Meeting in Edinburgh, reviewed the medical literature on skin cancer apps to explore the number of apps on the market, ascertain how accurate they are, and what the benefits and limitations of these technological solutions are. Examples of apps include tele-dermatology (which involves sending an image directly to a dermatologist), photo storage (which can be used by individuals to compare photos monthly to look for changes in a mole), and risk calculation (based on color and pattern recognition, or on fractal analysis).

The researchers found that some of these apps have a comparatively high success rate for the diagnosis of skin cancer. Teledermatology correctly identified 88 per cent of people with skin cancer and 97 per cent of those with benign lesions. Apps which use fractal theory analysis algorithms (detecting irregularities in a fractal pattern) were the next most successful category, these correctly identified 73 per cent of people with skin cancer and 83 per cent of people with benign lesions. These types of technology have huge potential, as 50 per cent of dermatology referrals in the UK relate to skin cancer. Early diagnosis results in up to 100 per cent five-year survival, compared with 25 per cent in women and 10 per cent in men diagnosed at a later stage.

Technology that can help with triaging would help alleviate pressure on dermatology departments and could also increase survival rates.
However, the researchers point to three major failings with some of the apps: a lack of rigorous published trials to show they work and are safe; a lack of input during the app development from specialists to identify which lesions are suspicious; and flaws in the technology used, namely how the photos are analysand.

The researchers explain that, without specialist input, the apps may not recognize rarer or unusual cancers. Even where the technology is efficient, if it has not been combined with specialist input from a dermatologist, it may not pick up on all red-flag symptoms.

In terms of technology, an area where color and pattern recognition software apps seem to particularly struggle currently, is in recognizing scaly, crusted, ulcerated areas or melanomas which do not produce pigment (amelanotic melanomas). This increases the number of false negatives and delays treatment.

Some apps that compare images on a monthly basis or 'advise' users to seek dermatologist review, based on a risk calculation, are not able to differentiate between finer details which would be identified using a dermatoscope (a magnifier that can be handheld or attached to a phone), or in person when touched by a dermatologist. If the app is based on advising patients whether to seek professional advice, then they may advise wrongly as they have not correctly identified finer details which may point to a more sinister lesion.

Maria Charalambides, of the University of Birmingham's College of Medical and Dental Sciences, who conducted the literature review, said: "Future technology will play a huge part in skin cancer diagnosis.

"However, until adequate validation and regulation of apps is achieved, members of the public should be cautious when using such apps as they come with risk.
"Any software that claims to provide a diagnostic element must be subject to rigorous testing and ongoing monitoring.
"Apps specifically based on patient education of skin cancer can offer public health benefits in terms of how to stay safe in the sun, or the warning signs to look out for.
"But as per the British Association of Dermatologists recommendations, most apps cannot currently substitute dermatologist review when it comes to actual diagnosis."

Matthew Gass of the British Association of Dermatologists, said: "These new technologies for the diagnosis of skin cancer are exciting, but the varying quality available makes it a difficult landscape for people to navigate.

"These apps are not a replacement for an expert dermatologist, but they can be a useful tool in the early detection of skin cancer.
"We urge people who are thinking about using these apps to research how they work and to be cautious regardless of their recommendations.
"If a patch of skin such as a mole is changing in shape or size, not healing or just doesn't seem right, go and see your GP regardless of what any app tells you."

Skin cancer is the most common cancer in the UK and rates have been climbing since the 1960s. Every year over 230,000 new cases of non-melanoma skin cancer (NMSC) - the most common type - are diagnosed in the UK. In addition to NMSC, there are approximately 16,000 new cases of melanoma every year, resulting in around 2,285 UK deaths annually.

Source: https://www.birmingham.ac.uk/news/latest/2018/07/skin-cancer-phone-apps-research.aspx