Study links bone strength to timing of puberty

A new study from the University of Bristol has linked bone strength to the timing of puberty.

Published today (Friday 9 August) in JAMA Network Open researchers looked at six repeated bone scans from 6389 children in Bristol's Children of the 90s study between the ages of ten and 25 to assess if the timing of puberty had any influence on bone density throughout adolescence and into early adulthood.

They found that although teens who had their pubertal growth spurt later than their peers did catch-up to some degree, they continued to have lower bone density than average for several years into adulthood.

Peak bone mass at the end of the teenage growth spurts is considered to be an indication of later risk of fracture and osteoporosis. Thanks to repeated measures covering 15 years in the large Children of the 90s study academics were able to examine how bone density changes over time to assess the extent to which later maturating individuals may 'catch-up' with their peers.

Lead author and Senior Research Associate in Epidemiology Dr Ahmed Elhakeem said:

Our research adds to the evidence that children who mature later may be at increased risk of fractures as they grow. They may also have increased risk of the fragile bone condition osteoporosis in later life."

Thanks to the Children of the 90s study we were able to look, for the first time, at children in great detail as they grow into young adults and observe their bone density. I'd like to see more advice available for people who reach puberty later on measures they can take to strengthen their bones.

The next steps should involve more detailed assessments of the long-term effects of puberty on growth and bone development."

Alison Doyle, Head of Operations and Clinical Practice at the Royal Osteoporosis Society, said:

This is important research that adds to a current gap in the evidence of understanding how bone density changes from puberty into early adulthood.

Investment in this area of research is vital in furthering our understanding of the causes of osteoporosis and helping people to maintain good bone health throughout life.

Understanding changes in bone density during puberty, and the interventions that people can take for their bone health now to prevent osteoporosis and fractures in the future, is an important step forward in finding a cure for this disease.

The charity's Osteoporosis and Bone Research Academy, which launched earlier this year, is working to build on these findings and create a future without osteoporosis."

The study did not make conclusions on any influence of the final adult height on the findings. As the study participants are still only in their twenties follow up with them as they age will be important to reach conclusions about fractures in later life.

Source:
Journal reference:

Elhakeem, A. et al. (2019) Association Between Age at Puberty and Bone Accrual From 10 to 25 Years of Age. JAMA Network Open. doi.org/10.1001/jamanetworkopen.2019.8918.

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