New therapeutic approach for children born to mothers who used cannabis during pregnancy

As a growing number of U.S. states legalize the medicinal and recreational use of marijuana, an increasing number of American women are using cannabis before becoming pregnant and during early pregnancy often to treat morning sickness, anxiety, and lower back pain. Although emerging evidence indicates that this may have long-term consequences for their babies' brain development, how this occurs remains unclear.

A University of Maryland School of Medicine study using a preclinical animal model suggests that prenatal exposure to THC, the psychoactive component of cannabis, makes the brain's dopamine neurons (an integral component of the reward system) hyperactive and increases sensitivity to the behavioral effects of THC during pre-adolescence. This may contribute to the increased risk of psychiatric disorders like schizophrenia and other forms of psychosis later in adolescence that previous research has linked to prenatal cannabis use, according to the study published today in journal Nature Neuroscience.

The team of researchers, from UMSOM, the University of Cagliari (Italy) and the Hungarian Academy of Sciences (Hungary), found that exposure to THC in the womb increased susceptibility to THC in offspring on several behavioral tasks that mirrors the effects observed in many psychiatric diseases. These behavioral effects were caused, at least in part, by hyperactivity of dopamine neurons in a brain region called the ventral tegmental area (VTA), which regulates motivated behaviors.

More importantly, the researchers were able to correct these behavioral problems and brain abnormalities by treating experimental animals with pregnenolone, an FDA-approved drug currently under investigation in clinical trials for cannabis use disorder, schizophrenia, autism, and bipolar disorder.

This is an exciting finding that suggests a therapeutic approach for children born to mothers who used cannabis during pregnancy. It also raises important questions that need to be addressed such as how does pregnenolone exert its effects and how can we improve its efficacy? Do these detrimental effects persist into adulthood, and if so, could they also be treated in a similar way?"

Joseph Cheer, PhD, Professor of Anatomy & Neurobiology and Psychiatry at the University of Maryland School of Medicine

The researchers concluded that as physicians caution pregnant women against alcohol and cocaine intake because of their detrimental effects to the fetus, they should also, based on these new findings, advise them on the potential negative consequences of using cannabis specifically during pregnancy.


  1. Pamela Mccoll Pamela Mccoll Canada says:

    A study at the University of Washington is recruiting pregnant women who are frequent users of marijuana ( THC or CBD) to assess the damage prenatal marijuana exposure has on the baby's development. The study is looking for human subjects who are in their first trimester of a pregnancy - before the 13 week mark. They are paying them $300.00 plus travel expenses incurred. There are huge issues in terms of ethics with the recruitment of these women and questions are raised by the Helsinki Agreement, The Belmont Report and the National Research Act - many questions in terms of the rights of these babies. We have filed a complaint with the federal agencies that govern human research, with the University and with NIDA who funded this study.  The key issues are the risk associated with ongoing use of marijuana to these babies that has already been established - specifically low birth weight, the issue of mandatory reporting law, the issue of confidentiality when the issue is child neglect or child abuse as defined under federal and state law, the issue of necessity and the issue of subjecting an infant to an MRI at six months of age.  It is now in the hands of the federal government to decide whether this study should be allowed to proceed. The Surgeon General issued an advisory in September of 2019 and specified that pregnant women should not use marijuana. His statement should be taken very seriously and all women should be given the facts and all medical professionals who come in contact with pregnant women should offer them help to see that they quit using immediately.

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
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