Researchers explore mutational signatures associated with exposure to microplastic pollutants

According to the World Health Organization (WHO), plastic products and their chemical derivatives present in the environment present public health concerns on a global scale and more exploration on the potential impact to human health is needed. Researchers from Rutgers Cancer Institute of New Jersey explored to what extent common components in microplastic pollutants cause DNA damage in human cells, which may leave complex mutational signatures in human cancers in organs that are at risk of relatively high level of environmental exposure.

Subhajyoti De, PhD, researcher at Rutgers Cancer Institute and an associate professor of pathology and laboratory medicine at Rutgers Robert Wood Johnson Medical School, is the senior author of the work and shares more about the findings published in the March 2021 online version of Nucleic Acids Research Cancer. (https://doi.org/10.1093/narcan/zcab004)

Why is this topic important to explore?

Traces of microplastic components have been found in potable water, food sources, and air, and are associated with elevated risk of a number of diseases including cancer. Bisphenol A (BPA) and Styrene-7,8-oxide (SO) are common compounds used in the production of epoxy resins and polycarbonate plastics; they are also major components of microplastic waste globally, and have recently been included in the list of carcinogens by the WHO's International Agency for Research on Cancer. The United States Environmental Protection Agency (EPA) reports that more than five million tons of synthetic compounds commonly consisting of BPA and SO are produced each year, thus lending to the need to further explore their impact on public health.

Describe the work and tell us what the team discovered.

Using experimental and genomic approaches, researchers Xiaoju Hu, PhD and Antara Biswas, PhD of my laboratory along with colleagues show that BPA and SO cause DNA damage and mutagenesis in human cells, and characterize the genome-wide point mutation and genomic rearrangement patterns associated with BPA and SO exposure. Analyzing data for more than 1,600 samples from 19 cancer cohorts representing most major types, the team found that tumors of digestive and urinary organs show relatively high similarity in mutational profiles of cell lines exposed to BPA or SO, and the burden of such mutations increases with age.

What are the implications of these findings?

Even within the same cancer type, proportions of corresponding mutational patterns vary among the cohorts from different countries, as does the amount of microplastic waste in ocean waters. BPA and SO are relatively moderate carcinogen, and other environmental agents can also potentially generate similar, complex mutational patterns in cancer genomes. Nonetheless, these findings call for systematic evaluation of public health consequences of microplastic exposure worldwide.

Source:
Journal reference:

Hu, X., et al. (2021) Mutational signatures associated with exposure to carcinogenic microplastic compounds bisphenol A and styrene oxide. NAR Cancer. doi.org/10.1093/narcan/zcab004.

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