Parietooccipital fissure contributes to the invasion pattern of posterior medial temporal gliomas

Researchers from four academic neurosurgical centers in Japan found that the parietooccipital fissure, which divides the temporal, occipital, and parietal lobes of the brain, acts as an obstacle that may result in less invasion of posterior medial temporal gliomas toward the occipital lobe.

Detailed findings, including images obtained with magnetic resonance and diffusion tensor imaging and fiber tractography, are provided in the article "Role of the parietooccipital fissure and its implications in the pathophysiology of posterior medial temporal gliomas," by Ichiyo Shibahara, MD, PhD, and colleagues, published today in the Journal of Neurosurgery (https://thejns.org/doi/10.3171/2021.7.JNS21990).

Gliomas are the most common primary brain tumors and have a poor prognosis even with currently available therapies. An important treatment strategy is surgical removal of as much tumor as possible without damaging important functional areas of the brain, a precaution that requires detailed information regarding the individual anatomy of each patient.

In this study, the authors performed tumor removal and assessed the anatomical architecture between the tumor location and the parietooccipital fissure in 24 patients with posterior medial temporal gliomas. In all patients, the anterior end of the parietooccipital fissure was the posterior border of the tumor. Magnetic resonance imaging of 20 patients showed that the tumor invaded along and anterior to the parietooccipital fissure, extending to the isthmus of the cingulate gyrus and the splenium of the corpus callosum. Fiber tracts running through the posterior medial temporal lobe were observed to correspond to these invasion patterns. Diffusion tensor imaging and fiber tractography also showed that fibers running toward the occipital lobe made a detour to avoid the parietooccipital fissure. These findings highlight the importance of the parietooccipital fissure in determining the invasion pattern of posterior medial temporal gliomas.

As the researchers state, their evidence confirms that in patients with posterior medial temporal glioma the parietooccipital fissure is an uninterrupted main sulcus comprising the posterior boundary of glioma invasion. Therefore, this fissure is a key landmark for understanding the complex anatomical architecture and invasion pattern of posterior medial temporal gliomas during preoperative analysis, information that may lead to more effective surgical treatment.

When asked about the study, Dr. Shibahara said, "All neurosurgeons/neuro-oncologists share some impression that gliomas invade in a specific direction; however, only a few studies have focused on demonstrating such phenomena. In this study we noticed that posterior medial temporal gliomas in different patients presented not only similar invasion patterns but also radiological features indicating a clear posterior border. We found that invasion of glioma cells was highly influenced by the parietooccipital fissure, suggesting a generalized pattern in which sulci act as the anatomical boundary of glioma invasion."

Source:
Journal reference:

Shibahara, I., et al. (2021) Role of the parietooccipital fissure and its implications in the pathophysiology of posterior medial temporal gliomas. Journal of Neurosurgery. doi.org/10.3171/2021.7.JNS21990.

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