Is night shift work rewiring our appetite and driving weight gain?

NewsGuard 100/100 Score

Bristol University of Scientists have uncovered why night shift work is associated with changes in appetite in a new University of Bristol-led study. The findings, published in Communications Biology, could help the millions of people who work through the night and struggle with weight gain.

Is night shift work rewiring our appetite and driving weight gain?Image Credit: BalanceFormCreative / Shutterstock

Scientists from Bristol and the University of Occupational and Environmental Health in Japan sought to understand how 'circadian misalignment' — a phenomenon commonly associated with 'jet lag' whereby the body's biological clock is disrupted — affects the hormones responsible for regulating appetite.

Prevalent in night shift workers, in this new study, the international team reveals how circadian misalignment can profoundly alter the brain's regulation of hormones controlling hunger to the detriment of metabolic health.

The team focused on glucocorticoid hormones in the adrenal gland, which regulate many physiological functions, including metabolism and appetite. Glucocorticoids are known to directly regulate a group of brain peptides controlling appetitive behavior, with some increasing appetite (orexigenic) and some decreasing appetite (anorexigenic).

In an experiment using animal models, comprising a control group and an out-of-phase 'jet-lagged' group, the team found misalignment between light and dark cues led the out-of-phase group's orexigenic hypothalamic neuropeptides (NPY) to become dysregulated, driving an increased desire to eat significantly more during the inactive phase of the day.

Strikingly, the team discovered that rats in the control group ate 88.4% of their daily intake during their active phase and only 11.6% during their inactive phase. In contrast, the 'jet-lagged' group consumed 53.8% of their daily calories during their inactive phase (without an increase in activity during this time). This equated to nearly five times more (460% more) than the control group consumed during the inactive phase. These results show that it is the timing of consumption that has been affected.

This discovery revealed how completely and significantly disordered the neuropeptides become when daily glucocorticoid levels are out of sync with light and dark cues. However, the authors suggest the neuropeptides identified in this study may be promising targets for drug treatments adapted to treat eating disorders and obesity.

Dr Becky Conway-Campbell, Research Fellow in Bristol Medical School: Translational Health Sciences (THS) and the study's senior author, said: "For people working throughout the night, a reversed body clock can play havoc with their health.

"For those who are working night shifts long-term, we recommend they try to maintain daylight exposure, cardiovascular exercise and mealtimes at regulated hours. However, internal brain messages to drive increased appetite are difficult to override with 'discipline' or 'routine' so we are currently designing studies to assess rescue strategies and pharmacological intervention drugs. We hope our findings also provide new insight into how chronic stress and sleep disruption leads to caloric overconsumption."

Stafford Lightman, Professor of Medicine at Bristol Medical School: THS and co-senior author on the study, added: "The adrenal hormone corticosterone, which is usually secreted in a circadian manner, is a significant factor in the daily control of brain peptides that regulate appetite. Furthermore, when we disturb the normal relationship of corticosterone with the day-to-night light cycle, it results in abnormal gene regulation and appetite during the period the animals normally sleep.

"Our study shows that when we disturb our normal bodily rhythms this in turn disrupts normal appetite regulation in a way that is at least in part a result of desynchrony between adrenal steroid hormone production and the timing of the light and dark cycle."

Dr. Benjamin Flynn, one of the study's co-authors who conducted the study while at Bristol but is now based at the University of Bath, added: "This is further evidence of how phase shift 'jet-lag' affects feeding behaviors and neuronal gene expression - data important for shift work co-morbidity research."

The Medical Research Council funded this research.



The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Breakthrough brain stimulator could revolutionize treatment for neurological disorders