New European research and innovation project launched to study healthy aging

A new European research and innovation project studying healthy aging launched this month. This collaborative project has been awarded funding from Horizon Europe, the EU's key funding program for research and innovation. Led by the University of Oulu in Finland, the consortium's research will use longitudinal cohorts and biobanks spanning the entire life course to explore how a person ages with multi-morbidity, which means having two or more long-term health conditions, and how it could be prevented.

By 2050, it is projected that the population aged 75 years and over will double in almost all European regions. This demographic projection presents important personal and societal challenges that require integrated and agile solutions. A person's opportunity to stay healthy through aging depends on their capacity to function in everyday life in a rapidly changing society. We advocate that this can be promoted from as early as possible and/or actively corrected by personalized prevention. However, to address the gaps in scientific evidence and the multiple ethical, societal and structural barriers which exist, researchers need to work together with policymakers and citizens of all ages.

One way of addressing these challenges is to gain a deeper understanding of people's diverse living environments, social stressors, and the biology of aging. Adopting a life-course and digital-based approach, the project will generate bio-psychosocial models and AI-assisted, age-friendly tools, to detect, prevent and reduce the risk of aging with multi-morbidity. The project team will design solutions for person-centred health and care services that focus on specific periods of life and are needs-based. These solutions will be co-designed with citizens, patients, healthcare providers, and policymakers, and include:

• Running cohort-based clinical studies, and
• Developing a Europe-wide digital, interactive, healthy ageing atlas to inform policymaking and strategic urban development for age-friendly neighbourhoods.

This highly ambitious project includes 22 partners, from research institutions, small and medium-sized enterprises, and an NGO, across 11 countries, with expertise in ethics and healthcare systems, environments and participatory science, life-course epidemiology, economics, molecular ageing, trustworthy artificial intelligence, integrated systems design, life-course based interventions, FAIR data management, nursing and healthcare, patient advocacy, and communication and knowledge management.

I am so happy our project has been awarded funding. It will enable us to understand the patterns of aging and then translate this knowledge into concrete, effective prevention programmes and solutions for people to age more healthily. Far too many people are now burdened with multiple chronic illnesses that combine mental health disorders such as depression and anxiety, and physical diseases such as obesity, diabetes, and cardiovascular diseases, into multi-morbidity. Unfortunately, we can observe the premise of these patterns emerging long before they are diagnosed. Yet, the knowledge about how such diseases, traditionally considered different in nature, may relate to each other is very uncertain. Personally, this is a dream project, and I am excited to get started. Equally exciting is that the project will kick-start the next follow-up of participants in the Northern Finland Birth Cohort 1966, one of the flagships of the University of Oulu started sixty years ago!"

Professor Sylvain Sebert, Project Coordinator

The STAGE project, which started on 1^st January 2024, is a six-year project with a total grant of €17.7m from Horizon Europe and €2.2m from UKRI. A comprehensive website will be launched by April 2024.

The consortium held its kick-off meeting on 23^rd and 24^th January 2024 in Helsinki, Finland, where partners presented and discussed the project strategies and activities needed to progress the research. Expected policy outcomes were also discussed and a workshop on defining and engaging stakeholders was held.