Study finds IFI27 and IFI6 as potential biomarkers for immune reconstitution in HIV patients

Announcing a new article publication for Zoonoses journal. No novel biomarkers are currently available for evaluating immune reconstitution among people living with HIV/AIDS (PLWH) receiving combined antiretroviral treatment (cART). This study analyzed the expression patterns of interferon-stimulating genes (ISGs) in PLWH with the aim of identifying potential biomarkers for immune reconstitution.

Study samples were collected from 102 PLWH, including 47 immunological non-responders (INRs) and 58 immunological responders (IRs). The expression of eight ISGs in the peripheral blood in INRs and IRs were detected by RT-qPCR. Expression differences between groups were analyzed with the Mann-Whitney U test, and a logistic regression model was developed to predict immune reconstitution.

Among eight ISGs, the expression levels of IFI27 and IFI6 were significantly higher in INRs than IRs (P=0.001 and 0.005, respectively). The model combining age, CD4+ T/CD8+ T ratio, IFI27, and IFI6 had the highest diagnostic value (AUC=0.836), with an optimal cut-off value of 0.6, sensitivity of 60.5%, and specificity of 98.1%. No significant change in the expression of IFI27 and IFI6 was observed in samples collected 3 years apart (P=0.1232 and 0.4877, respectively), and the model score negatively correlated with ΔCD4+ T cells (r=−0.2888, P=0.0465).

Enhanced expression of IFI27 and IFI6 in INRs are important characteristics that may serve as biomarkers of immune reconstitution after cART. The combination of age, CD4+ T/CD8+ T ratio, IFI27, and IFI6 was highly effective in discriminating INRs.

Source:
Journal reference:

Zhang, X., et al. (2024). Enhanced Expression of Two ISGs as Potential Biomarkers of Prognosis in HIV-Infected Immunological Non-Responders. Zoonoses. doi.org/10.15212/zoonoses-2024-0016.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Cautious optimism in San Francisco as new cases of HIV In Latinos decrease