Overview
Chronic inflammation is a major contributor to inflammatory, metabolic, neurological, and autoimmune disorders. This gives inflammasome inhibitors broad therapeutic potential, making them highly appealing to drug developers.
Recent advances in inflammasome biology have led to the development of a new line of medicines that target the proteins that regulate the production of inflammatory cytokines.
A critical milestone in successfully bringing this potential new class of therapeutics to market is ensuring that these drugs are effective in vitro and in vivo, on target at the appropriate dose, and have no off-target effects.
Selecting the most relevant assays, reference controls, and output metrics is crucial to accurately quantifying the efficacy of potential therapies and moving the best leads into clinical trials.
This whitepaper explains how a thorough understanding of the inflammasome is essential for accurate pre-clinical assay selection, addresses safety concerns, and examines Concept Life Sciences’ portfolio of inflammasome assays, which are developed to assess the efficacy of your candidate therapeutics.
About Concept Life Sciences
Concept Life Sciences is a leading contract research organisation (CRO) serving the global life sciences industry. For over 25 years, the company and its heritage companies have provided consultative and collaborative drug discovery and development services. Its approach, supported by passionate scientists and world-leading capabilities, enables clients to overcome complex scientific challenges across a broad range of therapeutic areas, improving program success rates. The company has successfully helped 29 candidates advance to the clinic.
Concept Life Sciences offers sophisticated translational biology services coupled with exceptional end-to-end chemistry capabilities across all modalities, including small molecules, biologics, peptides, and cell & gene therapies, with the ability to seamlessly integrate capabilities and provide bespoke solutions to address client needs.
Collectively, the company’s high-quality services and commitment to customer service across the drug development pathway enhance efficiency in drug discovery, helping clients advance their drugs to the clinic in as little as 32 months, well ahead of the industry average of 60 months.
Driven by a passion for science, Concept Life Sciences has around 230 employees, with around 70 % holding PhDs. The company operates from state-of-the-art UK facilities, headquartered near Manchester, with additional operations in Edinburgh, Dundee, and Sandwich. The headquarters is one of the UK’s largest medicinal chemistry CRO sites with key discovery services all under one roof.
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