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Breakthrough study finds genes behind calcium pyrophosphate deposition disease

In a first-of-its-kind genome-wide association study (GWAS) researchers have discovered two genes, RNF144B and ENPP1, that cause calcium pyrophosphate deposition (CPPD) disease in Americans of European and African descent.

28 May 2025

Alcohol abuse drug may mitigate trauma-induced damage, especially in females

Runaway cell death and inflammation triggered by severe trauma may be interrupted by a drug used to prevent alcohol abuse – and it may be particularly effective in females, according to new research led by University of Pittsburgh School of Medicine surgeon-scientists and published today in Science Translational Medicine.

28 May 2025

Cancer drug combo extends the lifespan of mice by 30%

The combination of two cancer drugs, rapamycin and trametinib, can extend the lifespan of mice by 30%, according to a study led by researchers at UCL and the Max Planck Institute for Biology of Ageing, Germany.

28 May 2025

Study highlights barriers to Alzheimer’s care in rural Georgia

Rural Georgians may find it difficult to access medication that could slow the progression of Alzheimer's disease, according to a new study from the University of Georgia.

28 May 2025

Non-drug therapies show real promise in calming agitation in Alzheimer’s

Non-drug therapies like music and light outperform medications in managing dementia-related agitation, enhancing patient care and safety for caregivers.

28 May 2025

New injection therapy can lead to long lasting blood pressure reduction

Results from a clinical trial led by researchers from Queen Mary University of London, published today in JAMA, show that giving people with high blood pressure an injection every six months can lead to a meaningful, sustained reduction in their blood pressure.

28 May 2025

Scientists identify early life opportunity for in vivo stem cell gene therapy

A team of scientists from the San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget) in Milan, Italy, has identified a unique window shortly after birth in which circulating blood stem cells can be effectively targeted with gene therapy directly in the body.

28 May 2025

Combination of trametinib and rapamycin extends lifespan in mice

The researchers were able to show that Trametinib alone extends the lifespan of mice by 5-10%, while Rapamycin alone increases lifespan by 15-20%. Together, the drugs have a combinatorial effect that extends the life of the mice by around 30%.

28 May 2025

Researchers develop bioactive peptide with therapeutic and regenerative potential

Since the COVID-19 pandemic, global interest in antiviral therapies has increased significantly. Recently, with the growing attention to peptide-based drugs such as Wegovy, demand for effective peptide therapeutics derived from natural substances is rapidly rising.

28 May 2025

Study explores older adults' perspectives on proactive deprescribing

This study explored older adults' perspectives on proactive deprescribing, identified barriers and enablers, and developed a typology of patient attitudes to inform patient-centered deprescribing interventions.

27 May 2025

A collaborative initiative by ISSCR toward responsible adoption of stem cell models

Advances in human stem cell-derived disease models have the potential to augment our predictive power for the efficacy and safety of new drugs.

27 May 2025

Traditional South Asian medicinal plants show promise in addressing memory disorders

The growing global population of elderly individuals has led to a dramatic rise in chronic diseases, including neurocognitive disorders such as Alzheimer's disease.

27 May 2025

Affordable HIV drug shows promise in improving vision for diabetic eye disease

An inexpensive, long-approved HIV drug can improve vision in patients with a blinding complication of diabetes more effectively and a much lower cost than many existing treatments, an initial clinical trial suggests.

27 May 2025

Researchers identify key nerve cells behind semaglutide's appetite reduction

A specific group of nerve cells in the brain stem appears to control how semaglutide affects appetite and weight – without causing nausea.

27 May 2025

Early statin therapy reduces heart attack and stroke risk in diabetes patients

Taking a statin medication is an effective, safe, and low-cost way to lower cholesterol and reduce risk of cardiovascular events.

27 May 2025

A ministroke can have major consequences

Kristin Kramer woke up early on a Tuesday morning 10 years ago because one of her dogs needed to go out. Then, a couple of odd things happened.

27 May 2025

Integrating pharmacogenomics into everyday clinical practice can transform patient care

Pharmacogenomics studies how individuals respond to drugs based on their genetic code. Using that knowledge to guide prescribing in routine care could lead to better outcomes for patients and save money for health systems.

26 May 2025

Researchers find way to protect mitochondria from stress-induced damage

Mitochondria are the cell's power plants: They turn the food we eat into the energy our cells can use. But when stress hijacks the process they use to maintain their quality, they get snipped into useless fragments and go into a tailspin that spreads from cell to cell and triggers a wide range of human diseases.

26 May 2025

Stress-induced sleep may hold the key to faster recovery

A new Neuron perspective reveals that stress can both disrupt and promote sleep, with specific brain circuits making stress-induced sleep a potential tool for recovery. This insight may lead to innovative approaches for building resilience and treating stress-related disorders.

25 May 2025

Aldosterone synthase inhibitor offers hope for treatment of uncontrolled hypertension

Lorundrostat, a novel therapy which blocks the production of aldosterone from the adrenal glands, demonstrated clinically meaningful and sustained reductions in blood pressure in 1,083 patients with uncontrolled or resistant hypertension, according to the results of a phase 3 trial announced today.

24 May 2025