Alzheimer's Disease News and Research

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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.

Stronger slow-wave sleep helps older adults regulate anxiety overnight

Researchers at Center for BrainHealth at The University of Texas at Dallas have identified a specific feature of sleep that helps older adults regulate anxiety overnight - and shown that, as it deteriorates with age, emotional wellbeing deteriorates along with it.

27 Apr 2026

Ultra-processed foods linked to measurable drops in human attention span

New research from Monash University, the University of São Paulo and Deakin University shows a diet high in heavily processed foods can negatively impact the brain's ability to focus and increases the risk of developing dementia.

25 Apr 2026

Molecular map reveals how Down syndrome alters brain development

Scientists at UCLA have created one of the first cellular-resolution molecular maps detailing how Down syndrome alters human brain development before birth - a resource that resolves longstanding contradictions in the field and could lay the groundwork for future therapeutic strategies.

25 Apr 2026

New insight into how molecular measures of aging relate to neuroimaging markers of brain health

A new research paper was published in Volume 18 of Aging-US on April 7, 2026, titled "Association of epigenetic age acceleration with MRI biomarkers of aging and Alzheimer's disease neurodegeneration."

25 Apr 2026

Scientists identify STING switch driving inflammation in Alzheimer’s disease

The brain has its own immune system, which detects threats and mounts a defense. A growing body of evidence has shown that in Alzheimer's disease, those immune cells are chronically overactivated, causing inflammation that damages the connections between brain cells.

24 Apr 2026

Unraveling the mystery of cognitive resilience in aging brains

Some brains resist Alzheimer's, even when the disease is already present. Researchers at the Netherlands Institute for Neuroscience have found that this likely depends on how specific brain cells, known as immature neurons, respond to damage caused by the disease.

24 Apr 2026

L-arginine stabilizes protein droplets and prevents harmful fibril formation

Protein droplets serve important biological functions within cells, but in neurodegenerative diseases like Alzheimer's, these liquid-like droplets can form solid-like clumps known as fibrils.

23 Apr 2026

Researchers receive NIH grant to accelerate Alzheimer's drug discovery efforts

Dr. Damian Young, investigator at Texas Children's Duncan Neurological Research Institute (Duncan NRI) and director of the Center for Drug Discovery at Baylor College of Medicine, along with collaborators has been awarded a $6.7 million grant from the National Institute on Aging (NIA), part of the National Institutes of Health (NIH), to develop new approaches to rapidly identify potential treatments for Alzheimer's disease and related dementias with the goal of accelerating the discovery of new therapies.

23 Apr 2026

New human cell model replicates key mechanisms of neurodegenerative diseases

Researchers at LMU have developed a human cell model that replicates key mechanisms of neurodegenerative diseases - with potential for novel therapies.

23 Apr 2026

Severe strokes significantly increase the risk of progressive dementia

As stroke severity increases, the risk of progressive cognitive decline and dementia substantially escalates, according to a national study led by Michigan Medicine researchers.

23 Apr 2026

Metabolic health may shape future dementia risk for Latino communities

Researchers from the University of California San Diego have found that diabetes is linked to changes in measurable biological signals in the blood that are associated with Alzheimer's disease and brain damage in Latino adults.

23 Apr 2026

Astrocytes form complex networks across the mouse brain

Cells long thought to play a secondary role in brain function build their own far-reaching connections, a new study in mice showed. These pathways appear to connect distant regions in ways that have not been mapped before.

23 Apr 2026

Cancer-linked mutations in the brain cells may drive Alzheimer’s disease

As the body ages, cells naturally accumulate dozens of genetic mutations each year. New research from Boston Children's Hospital, published in Cell, finds that the brain's resident immune cells, microglia, amass mutations in specific cancer-driving genes yet they don't manifest as cancer.

21 Apr 2026

High immune cell ratios may predict future Alzheimer's disease risk

Circulating white blood cells called neutrophils are some of the immune system's first responders. Their numbers shoot up during infection and inflammation, shifting the ratio of neutrophils to other types of immune cells in the blood.

21 Apr 2026

Alzheimer’s monoclonal antibodies fail to deliver meaningful results

Despite reducing amyloid plaques, antibody treatments for Alzheimer's fail to improve cognition, highlighting critical gaps in current therapeutic approaches.

21 Apr 2026

Last patient has completed AlzeCure's Phase Ib clinical study with NeuroRestore ACD856

AlzeCure Pharma AB (publ), a biotech company that develops candidate drugs for diseases affecting the nervous system, focusing on Alzheimer's disease and pain, today announced that the last patient’s last visit (LPLV) has now occurred in the ongoing Phase Ib clinical trial of ACD856, the lead drug candidate within the NeuroRestore platform, which is being developed for Alzheimer’s disease and other indications.

From AlzeCure Pharma AB 21 Apr 2026

Brain organoids may guide Alzheimer’s diagnosis and treatment

Scientists from Johns Hopkins Medicine report new evidence that clusters of brain tissue derived from the cells of patients with Alzheimer's disease may be used to evaluate how certain patients with the neurodegenerative condition may respond to drugs commonly prescribed to treat psychiatric symptoms of the disorder.

20 Apr 2026

Having more children associated with lower stroke risk for women

While some say having lots of kids can make you lose your faculties, a new study suggests otherwise.

20 Apr 2026

High-resolution study maps molecular differences across six human cortical regions

A new analysis of individual brain cells across several human brain regions reveals subtle but widespread differences in gene activity between male and female brains. This may help explain why some psychiatric and neurological disorders appear to affect the biological sexes differently, researchers report.

17 Apr 2026

Researchers discover a molecular signature to flag dysfunctional aging cells

UCLA researchers have identified a rogue population of immune cells that quietly accumulates in aging tissues and in the livers of people with fatty liver disease. Clearing these cells, they found, dramatically reduced inflammation and reversed liver damage in mice - even while the animals remained on an unhealthy diet.

16 Apr 2026