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Unlocking the code: BigRNA's deep learning model predicts RNA behavior

Researchers have developed BigRNA, a groundbreaking deep learning model capable of predicting RNA behavior, including tissue-specific expression and splicing, directly from genomic DNA sequences. The model excels in identifying pathogenic variants and could be a game-changer in the development of personalized RNA-based therapies for treating genetic diseases.

28 Sep 2023

Vaxzevria vaccine boosts mucosal immunity in COVID-19 recovered

Study highlights the ability of the Vaxzevria vaccine in inducing robust mucosal antibody responses, especially in COVID-19-recovered individuals, showcasing a notable defense against various SARS-CoV-2 variants. However, it emphasizes the need for booster doses to enhance anti-SARS-CoV-2 mucosal immunity, especially in infection-naïve individuals, to broaden protection against emerging viral variants.

28 Sep 2023

Natural antibiotic thiostrepton reveals new hope for inflammatory bowel disease treatment

Researchers explored the therapeutic impact of Thiostrepton on experimental colitis by examining its effects on colon inflammation and determining its targets through various biochemical approaches.

28 Sep 2023

Zoonotic spillover safeguarding: computationally designed antigen targets range of coronaviruses

Researchers used an interdisciplinary approach incorporating phylogenetics, 3D protein modeling, and plasmid design to identify and computationally design an antigen representing the core of most currently known sarbecoviruses.

27 Sep 2023

Could a mushroom-derived product be the future of lung cancer prevention?

Researchers find that a mushroom-derived product, GLSF, shows promise in reducing lung toxicity and tumor development induced by tobacco smoke carcinogens in mice. The study opens the door for future clinical trials, potentially offering a natural preventive measure against lung cancer.

26 Sep 2023

Key player in ovarian cancer may have implications for PCOS

Researchers explore the involvement and altered expression of BBOX1-AS1 and microRNA-19b in polycystic ovary syndrome.

26 Sep 2023

Intranasal vaccine shows promise against COVID variants in hamsters

Intranasal mRNA-LNP vaccines show promise in Syrian golden hamsters, effectively reducing SARS-CoV-2 viral loads and lung pathology. The study suggests potential efficacy against new variants, setting the stage for future research in human applications.

25 Sep 2023

Comparing two plasma p-tau217 assays for Alzheimer's detection and monitoring

Researchers compared two commercially available blood tests based on the biomarker p-tau217 for diagnosing Alzheimer's disease in 294 patients. Both tests demonstrated robust diagnostic capabilities, strongly correlating with established Alzheimer's biomarkers from PET scans.

24 Sep 2023

Using recombinase polymerase amplification for rapid and visual detection of monkey B virus

Announcing a new article publication for Zoonoses journal. Monkey B virus (BV) infection in humans and other macaque species has a mortality rate of approximately 80%.

22 Sep 2023

Atellica Solution Portfolio: Engineering predictability in a highly unpredictable lab environment

In this interview, News Med talks to Lisa Cratty about the unpredictable lab environment and engineering predictability.

From Siemens Healthineers 22 Sep 2023

AlphaMissense revolutionizes genetic mutation analysis for disease prediction

AlphaMissense, an adaptation of AlphaFold, offers a highly accurate model for predicting the pathogenicity of human proteome-wide missense variants at the single amino acid level. The model outperforms existing methods, providing valuable insights for diagnosing rare diseases and developing targeted therapies.

20 Sep 2023

Scientists develop Australia’s first-of-its-kind next-gen mpox diagnostic tool

In a collaborative study published in The Lancet Microbe, the team of scientists, led by the Peter Doherty Institute for Infection and Immunity (Doherty Institute) and WEHI (Walter and Eliza Hall Institute of Medical Research), revealed MPXV-CRISPR – a powerful diagnostic tool capable of detecting MPXV in clinical samples with acute precision and at a faster rate than any other method, thanks to the power of CRISPR technology.

20 Sep 2023

Game-changing point-of-care assay could revolutionize Mpox detection worldwide

Researchers developed a point-of-care assay for the rapid detection of mpox virus.

20 Sep 2023

CST and Leica Biosystems partner to enable companion diagnostics for personalized medicine

Cell Signaling Technology (CST), a life science discovery technology company and leading provider of antibodies, kits, and services, is partnered with Leica Biosystems, a technology leader in automated staining and brightfield and fluorescent imaging, to support the development of companion diagnostics (CDx) assays using the extensive portfolio of best-in-class antibodies from CST validated for immunohistochemistry (IHC).

From Cell Signaling Technology 20 Sep 2023

Is sucralose the safer sweetener for your gut health?

The study found that consuming a beverage sweetened with sucrose significantly increased bacterial endotoxin levels in the blood, a marker for inflammation and gut barrier dysfunction, while no such effect was observed with sucralose-sweetened drinks. The findings suggest that sucralose may be a safer alternative to sucrose in terms of intestinal health and inflammation.

19 Sep 2023

Real-time live tissue sensitivity assay could be used as a personalized strategy for pancreatic cancer

A new research paper was published in Oncotarget's Volume 14 on September 15, 2023, entitled, "Real time ex vivo chemosensitivity assay for pancreatic adenocarcinoma."

19 Sep 2023

Inactivated poliovirus vaccine elicits persistent immunity for up to 10 years

The neutralizing antibodies persistence of the Sabin strain-derived inactivated poliovirus vaccine.

19 Sep 2023

Ongoing gene therapy trials have driven increased use of ALS genetic testing, finds study

Researchers at The Ohio State University Wexner Medical Center and College of Medicine led the creation of evidence-based consensus guidelines for genetic testing and counseling for patients with amyotrophic lateral sclerosis (ALS), a neurodegenerative disease that affects the cells in the brain and spine.

19 Sep 2023

Researchers identify a rare cause of male infertility and discover a potential cure

Researchers investigated the genetic underpinning of asthenozoospermia, the leading cause of male fertility.

18 Sep 2023

Meridian Bioscience announces FDA clearance for innovative Curian® Shiga Toxin Assay

Meridian Bioscience, Inc., a leading global provider of diagnostic testing solutions and life science raw materials.

From Meridian Bioscience, Inc. 18 Sep 2023

Assay News and Research

Unlocking the code: BigRNA's deep learning model predicts RNA behavior

Vaxzevria vaccine boosts mucosal immunity in COVID-19 recovered

Natural antibiotic thiostrepton reveals new hope for inflammatory bowel disease treatment

Zoonotic spillover safeguarding: computationally designed antigen targets range of coronaviruses

Could a mushroom-derived product be the future of lung cancer prevention?

Key player in ovarian cancer may have implications for PCOS

Intranasal vaccine shows promise against COVID variants in hamsters

Comparing two plasma p-tau217 assays for Alzheimer's detection and monitoring

Using recombinase polymerase amplification for rapid and visual detection of monkey B virus

Atellica Solution Portfolio: Engineering predictability in a highly unpredictable lab environment

AlphaMissense revolutionizes genetic mutation analysis for disease prediction

Scientists develop Australia’s first-of-its-kind next-gen mpox diagnostic tool

Game-changing point-of-care assay could revolutionize Mpox detection worldwide

CST and Leica Biosystems partner to enable companion diagnostics for personalized medicine

Is sucralose the safer sweetener for your gut health?

Real-time live tissue sensitivity assay could be used as a personalized strategy for pancreatic cancer

Inactivated poliovirus vaccine elicits persistent immunity for up to 10 years

Ongoing gene therapy trials have driven increased use of ALS genetic testing, finds study

Researchers identify a rare cause of male infertility and discover a potential cure

Meridian Bioscience announces FDA clearance for innovative Curian® Shiga Toxin Assay

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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