Fibrosis News and Research

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Fibrosis is the growth of fibrous tissue.

Soft wireless bioelectronic implant targets the splenic nerve to reduce inflammation

For millions suffering from chronic inflammatory diseases like inflammatory bowel disease (IBD), managing flare-ups often involves powerful drugs with significant side effects.

1 Jan 2026

Study sheds new light on the role of NSUN2 protein in cardiac hypertrophy and heart failure

A recent study published in Engineering has shed new light on the role of the protein NSUN2 in the development of cardiac hypertrophy and heart failure.

30 Dec 2025

Euphorbia neriifolia L. extract protects against cardiomyocyte injury and heart failure

Announcing a new publication for Acta Materia Medica journal. Heart failure (HF) remains a major global health challenge with limited therapeutic options, thus prompting the search for novel cardioprotective agents among traditional Chinese medicines.

30 Dec 2025

Trial evaluates a traditional Chinese herbal formula for diabetic kidney disease with macroalbuminuria

Diabetic kidney disease affects a growing proportion of people with diabetes and remains the leading cause of end-stage renal disease.

30 Dec 2025

CT-based quantification of tumor fibrosis guides chemotherapy in pancreatic cancer

On October 3, 2025, a multicenter team from Shenzhen University, Xiangya Hospital of Central South University, Zhujiang Hospital of Southern Medical University, Wuxi People's Hospital Affiliated to Nanjing Medical University, among others jointly reported a novel noninvasive method for quantifying tumor fibrosis based on preoperative enhanced CT.

23 Dec 2025

Fatty diets reprogram hepatocytes and increase liver cancer risk

One of the biggest risk factors for developing liver cancer is a high-fat diet. A new study from MIT reveals how a fatty diet rewires liver cells and makes them more prone to becoming cancerous.

22 Dec 2025

Splicing regulator U2AF1 promotes angiogenesis in cardiac injury

A study published in Engineering shows that a protein called U2 small nuclear RNA auxiliary factor 1 (U2AF1), released by immune cells known as macrophages, helps grow new blood vessels in the heart after a myocardial infarction (MI) by altering how the gene Yap1 is spliced.

22 Dec 2025

Flu wave’s hidden cost on people with cystic fibrosis

People with cystic fibrosis (CF) are uniquely vulnerable to the flu wave currently ripping through the UK, a clinical researcher from The University of Manchester has warned.

18 Dec 2025

High fructose intake increases fatty liver risk

Excessive fructose intake from soft drinks is linked to liver damage and NAFLD. Lifestyle modifications are essential for effective prevention and treatment.

16 Dec 2025

Single-cell RNA-seq reveals FBLN7's role in adipose tissue fibrosis

Fibrosis, resulting from excess extracellular matrix (ECM) deposition, is a feature of adipose tissue (AT) dysfunction and obesity-related insulin resistance.

13 Dec 2025

Exclusive licensing agreement accelerates PHD inhibitor development for anemia in CKD patients

Insilico Medicine ("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, and TaiGen Biotechnology, a listed discovery-based and market-focused pharmaceutical company, as well as TaiGen Biopharmaceuticals, its wholly-owned Beijing subsidiary (both referred to as "TaiGen"), today announced an exclusive pipeline out-licensing collaboration.

12 Dec 2025

AI-guided discovery of selective DGKα inhibitors to overcome checkpoint resistance in solid cancers

Insilico Medicine has developed a new class of small molecule inhibitors targeting diacylglycerol kinase alpha (DGKα) designed to restore T cell function and overcome resistance to immune checkpoint blockades in solid cancers.

12 Dec 2025

Scientists outline how organ rejuvenation strategies could solve the donor shortage

Researchers outline why organs from older donors are often discarded and identify the biological and immunological pathways that make them vulnerable to injury. They also highlight emerging rejuvenation technologies including machine perfusion, senotherapeutics, and regenerative strategies that could safely expand the donor pool.

11 Dec 2025

Blocking collagen signaling improves the delivery of macromolecular drugs in pancreatic cancer

Pancreatic cancer is one of the deadliest malignancies, with survival rates remaining dismally low despite major advances in oncology.

11 Dec 2025

Enterprise Therapeutics publishes results of Phase 1 study of ETD001, a novel inhaled ENaC blocker for treatment of Cystic Fibrosis, in The Journal of Cystic Fibrosis

Enterprise Therapeutics Ltd (Enterprise), a biopharmaceutical company dedicated to the discovery and development of novel therapies to improve the lives of people with respiratory diseases, today announced the publication of a peer reviewed study in The Journal of Cystic Fibrsosis.

9 Dec 2025

Cystic fibrosis patients on triple-drug therapy can safely reduce daily lung treatments

A new multi-site study led by researchers at CU Anschutz shows that people with cystic fibrosis (CF) who start the triple-drug therapy elexacaftor/tezacaftor/ivacaftor (ETI) can safely reduce many of their daily lung treatments while maintaining good health for years.

4 Dec 2025

Sweat testing could transform drug monitoring and diabetes care

Innovative sweat sampling techniques could revolutionize diagnostics, offering insights into glucose levels and environmental toxins with minimal discomfort.

4 Dec 2025

Asian IBD patients show lower PSC prevalence and better clinical outcomes

Primary sclerosing cholangitis (PSC) is a chronic, progressive inflammatory disease characterized by fibrosis and bile duct stricturing, which ultimately leads to cirrhosis and liver failure. PSC is strongly associated with both types of inflammatory bowel disease (IBD), namely, ulcerative colitis and Crohn's disease.

2 Dec 2025

Generative AI aids discovery of ISM3830's novel scaffold

Casitas B-lineage lymphoma-b (CBLB) is an E3 ubiquitin–protein ligase that functions as an intracellular checkpoint and master negative regulator of T‑cell and natural killer (NK) cell activation, playing a central role in modulating T-cell activation and immune tolerance, and its inhibition enhances T cells and NK cells function, also provides a strategy for the function restoration of exhausted T cells.

1 Dec 2025

New evidence supports ablation for high-risk patients with AFib and sleep apnea

Obstructive sleep apnea and atrial fibrillation are two conditions that share a potentially deadly link. Having one increases the odds of developing the other, and together, the breathing difficulties of sleep apnea combined with the irregular heartbeat of atrial fibrillation (AFib) can result in life-threatening cardiovascular risks.

1 Dec 2025

Fibrosis News and Research

Further Reading

Soft wireless bioelectronic implant targets the splenic nerve to reduce inflammation

Study sheds new light on the role of NSUN2 protein in cardiac hypertrophy and heart failure

Euphorbia neriifolia L. extract protects against cardiomyocyte injury and heart failure

Trial evaluates a traditional Chinese herbal formula for diabetic kidney disease with macroalbuminuria

CT-based quantification of tumor fibrosis guides chemotherapy in pancreatic cancer

Fatty diets reprogram hepatocytes and increase liver cancer risk

Splicing regulator U2AF1 promotes angiogenesis in cardiac injury

Flu wave’s hidden cost on people with cystic fibrosis

High fructose intake increases fatty liver risk

Single-cell RNA-seq reveals FBLN7's role in adipose tissue fibrosis

Exclusive licensing agreement accelerates PHD inhibitor development for anemia in CKD patients

AI-guided discovery of selective DGKα inhibitors to overcome checkpoint resistance in solid cancers

Scientists outline how organ rejuvenation strategies could solve the donor shortage

Blocking collagen signaling improves the delivery of macromolecular drugs in pancreatic cancer

Enterprise Therapeutics publishes results of Phase 1 study of ETD001, a novel inhaled ENaC blocker for treatment of Cystic Fibrosis, in The Journal of Cystic Fibrosis

Cystic fibrosis patients on triple-drug therapy can safely reduce daily lung treatments

Sweat testing could transform drug monitoring and diabetes care

Asian IBD patients show lower PSC prevalence and better clinical outcomes

Generative AI aids discovery of ISM3830's novel scaffold

New evidence supports ablation for high-risk patients with AFib and sleep apnea

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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