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Leptin variations may influence brain health and dementia development

New research is more closely linking obesity to dementia. Higher levels of leptin, a hormone that helps maintain normal body weight, is associated with better signal-transmitting brain white matter in middle-aged adults, according to a study by The University of Texas Health Science Center at San Antonio (UT Health San Antonio).

18 Sep 2024

Study helps explain why having ApoE4 increases risk of neurodegeneration

A new study helps explain why having ApoE4—the gene variant most closely linked to Alzheimer's disease—increases the risk of neurodegeneration and white matter damage.

18 Sep 2024

Study links metal exposure to increased risk of atherosclerosis

Metal exposure from environmental pollution is associated with increased calcium buildup in the coronary arteries at a level comparable to traditional risk factors like smoking and diabetes, according to a study published today in JACC, the flagship journal of the American College of Cardiology.

18 Sep 2024

OU Health Sciences receives major cancer research grant

A $5.3 million National Institutes of Health grant awarded to the University of Oklahoma Health Sciences will support advanced cancer research in Oklahoma. The Centers of Biomedical Research Excellence (COBRE) grant is designed to build research capacity and help early-career researchers establish independently funded laboratories.

18 Sep 2024

New insights into the mechanisms of efavirenz-induced neurotoxicity

Efavirenz is an important drug for treating HIV infection, but it has negative effects that can significantly impact patients' quality of life over time. It causes neuropsychiatric disorders and neurocognitive impairment in roughly 50 percent of patients. The drug is associated with abnormal lipid levels in blood plasma, but the molecular mechanisms responsible for negative clinical observations are unknown.

18 Sep 2024

UC San Diego researcher receives $21 million grant to study sensory coordination in animals

For all animals, sensory processing is a matter of survival. Sight, smell, touch, taste and hearing - the coordination of these senses together helps them find food, return to shelter and escape danger.

17 Sep 2024

Large-scale study to explore impact of type 1 diabetes on brain development in children

About half of adults with type 1 diabetes face significant cognitive impairment, including problems with working memory and executive function that affect day-to-day thinking. But less is known about how the condition affects children during a window of time known to be critical for healthy brain development.

17 Sep 2024

3D mammograms show greater accuracy in detecting breast cancer

The newer, 3D form of breast screening, known as digital breast tomosynthesis (DBT), is more effective at detecting breast cancer than traditional 2D digital mammography (DM).

17 Sep 2024

UC San Diego Health trials spatial computing technology in operating room

Minimally invasive surgeons at UC San Diego Health are the first in the nation to evaluate the potential use of spatial computing apps on Apple Vision Pro in the operating room.

17 Sep 2024

LJI breakthrough offers hope for universal antiviral against filoviruses

At this moment, the world has few tools to combat deadly filoviruses, such as Ebola and Marburg viruses. The only approved vaccine and antibody treatments protect against just one filovirus species.

17 Sep 2024

10-year study shows DBT outperforms 2D mammography in breast cancer detection

According to a new 10-year study, screening for breast cancer with digital breast tomosynthesis (DBT) increases cancer detection rates and significantly reduces the rate of advanced cancers compared to conventional 2D digital mammography.

17 Sep 2024

Research reveals only a few brain regions remain untouched by transition to motherhood

Research shows pregnancy triggers neuroanatomical changes in the brain, with decreased cortical volume and increased white matter integrity over gestation.

17 Sep 2024

Newcells Biotech launches high-content and high-throughput imaging suite to advance pre-clinical drug development programmes

Newcells Biotech (“Newcells”), a leading drug discovery partner specialising in the development of in vitro models and bespoke assay services to improve the prediction of in vivo human outcomes, today announced the launch of its imaging suite and advanced lung Fibroblast-to-Myofibroblast Transition (FMT) assay.

From Newcells Biotech 17 Sep 2024

Brain measurements prove more accurate in predicting mild cognitive impairment

University of Oklahoma researchers recently published a study showing that several measurements of the brain, including blood flow and the brain's ability to compensate for the lack of it, are better predictors of mild cognitive impairment than risk factors like hypertension and high cholesterol.

16 Sep 2024

New research reveals dynamic brain changes throughout pregnancy

Pregnancy is a transformative time in a person's life where the body undergoes rapid physiological adaptations to prepare for motherhood - that we all know.

16 Sep 2024

New study finds no bias in opioid treatment suggestions by AI models

A new study from Mass General Brigham researchers provides evidence that large language models (LLMs), used for generative artificial intelligence (AI), ChatGPT-4 and Google's Gemini, demonstrated no differences in suggested opioid treatment regimens for different races or sexes.

16 Sep 2024

New microscopy technique detects early Parkinson's disease indicators

Researchers at Tel Aviv University cooperated with three major Israeli medical centers to develop a new method for detecting protein aggregation in cells – a hallmark of Parkinson's disease.

16 Sep 2024

Researchers seek early Alzheimer's detection with MRSI

University of Virginia professor Mathews Jacob has secured a $3.9 million grant to advance his innovative research on detecting Alzheimer's disease in its early stages. Jacob, who specializes in electrical and computer engineering, is teaming up with researchers from the University of Iowa and the University of California-San Francisco to push the boundaries of imaging technology that tracks the brain's metabolic changes - offering a fresh perspective on studying neurodegenerative disorders.

14 Sep 2024

New biomarker helps differentiate Alzheimer’s from primary 4-repeat tauopathies

A new biomarker makes it easier to distinguish between Alzheimer's and primary tauopathy.

13 Sep 2024

New AI imaging technique enhances retinal disorder diagnosis

Population-based studies have shown retinal disorders are the most common cause of irreversible blindness in developed countries and the second most common cause of blindness after cataracts in developing countries.

12 Sep 2024