Alzheimer's Disease News and Research

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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.

Researchers identify the cause of severe canine juvenile epilepsy

In a study conducted at the University of Helsinki, researchers found a cause for severe epilepsy resulting in death in Parson Russell Terrier puppies at a few months of age. A change in the PITRM1 gene can lead to a dysfunction of mitochondria, the cellular energy pumps.

21 Apr 2021

Inhibition of Meprin Β enzyme can trigger the development of Alzheimer's disease, cancer

Researchers at Johannes Gutenberg University Mainz (JGU) in Germany and the Institute of Molecular Biology of Barcelona in Spain have discovered how the blood plasma protein fetuin-B binds to the enzyme meprin β and used a computer model to visualize their findings.

21 Apr 2021

Chaperone protein imbalance can play key role in initiating toxic tau buildup in the aging brain

Chaperone protein imbalance can play a significant role in initiating toxic accumulation of tau in the aging brain - an early step in the development of Alzheimer's disease and related neurodegenerative disorders known as tauopathies, a new preclinical study by University of South Florida Health (USF Health) neuroscientists suggests.

20 Apr 2021

TBI patients face challenges in healthcare utilization, finds study

Patients who suffer from traumatic brain injuries (TBI) often need a great deal of healthcare services after the injury, but the extent of care utilization is unknown.

20 Apr 2021

K162 molecule could inhibit β-amyloids ' toxicity associated with Alzheimer's disease

Alzheimer's disease (AD) is a form of progressive dementia interfering with daily living. It is caused by the decline in the number of brain cells resulting in the deterioration of our mental abilities.

20 Apr 2021

Report highlights the effectiveness of collaborative care model for patients with dementia

A new report from the National Academies of Sciences, Engineering, and Medicine (National Academies) details the state of dementia care and research in America and provides guidance on future research to make sure both patients and their families are having their needs met by the care they receive.

19 Apr 2021

Light therapy offers a safe, cost-effective alternative for treatment of neurodegenerative diseases

A lot about the human brain and its intricacies continue to remain a mystery. With the advancement of neurobiology, the pathogenesis of several neurodegenerative diseases (ND) has been uncovered to a certain extent along with molecular targets around which current therapies revolve.

19 Apr 2021

Protein-coding gene may worsen tau protein tangles associated with Alzheimer's

In a new paper published in Nature Communications, Mayo Clinic researchers and collaborators report the protein-coding gene SERPINA5 may worsen tau protein tangles, which are characteristic of Alzheimer's disease, and advance disease.

19 Apr 2021

SARS-CoV-2 nucleoprotein can trigger α-synuclein amyloid fibril formation

A new study, released as a preprint on the bioRxiv* server, casts some light on the pathogenesis of acute and subacute neurological complications associated with COVID-19.

19 Apr 2021

KHN’s ‘What the Health?’: Pause and effect on Covid vaccines

The effort to vaccinate Americans against covid-19 took a hit this week. The Centers for Disease Control and Prevention and the Food and Drug Administration jointly called for a pause in use of the vaccine made by Johnson & Johnson while experts try to figure out whether it is responsible for a small number of serious blood clots, mostly in women of childbearing age.

17 Apr 2021

Study sheds light on how tau aggregates promote Alzheimer’s disease

Look deep inside the brain of someone with Alzheimer's disease, most forms of dementia or the concussion-related syndrome known as chronic traumatic encephalopathy (CTE) and you'll find a common suspected culprit: stringy, hairball-like tangles of a protein called tau.

17 Apr 2021

Targeting brain protein may lead to new therapeutic approaches for neurodegenerative disorders

Neurological disorders are the number one cause of disability in the world, leading to seven million deaths each year. Yet few treatments exist for these diseases, which progressively diminish a person's ability to move and think.

16 Apr 2021

Personality trait neuroticism associated with higher risk of Parkinson's disease

New research from the Florida State University College of Medicine has found that the personality trait neuroticism is consistently associated with a higher risk of developing the brain disorder Parkinson's disease.

15 Apr 2021

UCSB professor receives 2021 Potamkin Prize for major contributions to Alzheimer’s research

When UC Santa Barbara neurology professor Kenneth S. Kosik was a newly minted graduate in 1972, with bachelor's and master's degrees in English literature from Case Western University, becoming one of the foremost authorities in the field of Alzheimer's research was probably nowhere on his radar. But that would soon change.

15 Apr 2021

Researchers discover a new way to prevent brain nerve cells from deteriorating after injury

Violent blows or jolts to the head can cause traumatic brain injury (TBI), and there are currently about five million people in the U.S. living with some form of chronic impairment after suffering a TBI.

13 Apr 2021

Stem cells of the nervous system age rapidly, shows study

In a new study published in Cell Stem Cell, a team led by USC Stem Cell scientist Michael Bonaguidi, PhD, demonstrates that neural stem cells - the stem cells of the nervous system - age rapidly.

12 Apr 2021

Study demonstrates profound anhedonia in people with frontotemporal dementia

People with early-onset dementia are often mistaken for having depression and now Australian research has discovered the cause: a profound loss of ability to experience pleasure - for example a delicious meal or beautiful sunset - related to degeneration of 'hedonic hotspots' in the brain where pleasure mechanisms are concentrated.

12 Apr 2021

Imbalanced bacterial community in the gums linked to Alzheimer's disease biomarker

Older adults with more harmful than healthy bacteria in their gums are more likely to have evidence for amyloid beta--a key biomarker for Alzheimer's disease--in their cerebrospinal fluid (CSF), according to new research from NYU College of Dentistry and Weill Cornell Medicine.

12 Apr 2021

Sleep apnea treatment linked to lower risk of Alzheimer's and other dementias

A new study finds older adults who received positive airway pressure therapy prescribed for obstructive sleep apnea may be less likely to develop Alzheimer's disease and other kinds of dementia.

9 Apr 2021

Study shows intricate association of aluminum in the neuropathology of familial Alzheimer's disease

This study builds upon two earlier published studies (Mold et al., 2020, Journal of Alzheimer's Disease Reports) from the same group. The new data, also published in the Journal of Alzheimer's Disease Reports, demonstrate that aluminum is co-located with phosphorylated tau protein, present as tangles within neurons in the brains of early-onset or familial Alzheimer's disease (AD).

9 Apr 2021

Alzheimer's Disease News and Research

Further Reading

Researchers identify the cause of severe canine juvenile epilepsy

Inhibition of Meprin Β enzyme can trigger the development of Alzheimer's disease, cancer

Chaperone protein imbalance can play key role in initiating toxic tau buildup in the aging brain

TBI patients face challenges in healthcare utilization, finds study

K162 molecule could inhibit β-amyloids ' toxicity associated with Alzheimer's disease

Report highlights the effectiveness of collaborative care model for patients with dementia

Light therapy offers a safe, cost-effective alternative for treatment of neurodegenerative diseases

Protein-coding gene may worsen tau protein tangles associated with Alzheimer's

SARS-CoV-2 nucleoprotein can trigger α-synuclein amyloid fibril formation

KHN’s ‘What the Health?’: Pause and effect on Covid vaccines

Study sheds light on how tau aggregates promote Alzheimer’s disease

Targeting brain protein may lead to new therapeutic approaches for neurodegenerative disorders

Personality trait neuroticism associated with higher risk of Parkinson's disease

UCSB professor receives 2021 Potamkin Prize for major contributions to Alzheimer’s research

Researchers discover a new way to prevent brain nerve cells from deteriorating after injury

Stem cells of the nervous system age rapidly, shows study

Study demonstrates profound anhedonia in people with frontotemporal dementia

Imbalanced bacterial community in the gums linked to Alzheimer's disease biomarker

Sleep apnea treatment linked to lower risk of Alzheimer's and other dementias

Study shows intricate association of aluminum in the neuropathology of familial Alzheimer's disease

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