Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Study uncovers how the body's bile acids bind to block C. diff's most dangerous toxin

In a major step towards a precision therapy for Clostridioides difficile (C. diff) infection, researchers at The Hospital for Sick Children (SickKids) have uncovered how the body's bile acids bind to block C. diff's most dangerous toxin.

9 Dec 2025

Intellicule secures $217,941 SBIR Phase I grant to develop biomolecular modeling software

Intellicule, a software company whose solutions determine the 3D structures of biomolecules imaged with cryogenic-electron microscopy (cryo-EM), has received a $217,941 Small Business Innovation Research (SBIR) Phase I grant from the National Institutes of Health.

8 Dec 2025

Scientists uncover why SETX-deficient cancer cells rely on error-prone DNA repair

The DNA inside our cells is constantly being damaged, and one of the worst kinds of damage is a double-strand break-when both sides of the DNA helix are cut at once.

4 Dec 2025

Generative AI aids discovery of ISM3830's novel scaffold

Casitas B-lineage lymphoma-b (CBLB) is an E3 ubiquitin–protein ligase that functions as an intracellular checkpoint and master negative regulator of T‑cell and natural killer (NK) cell activation, playing a central role in modulating T-cell activation and immune tolerance, and its inhibition enhances T cells and NK cells function, also provides a strategy for the function restoration of exhausted T cells.

1 Dec 2025

Machine learning tool identifies compounds that induce cancer cells into senescence

A new research paper featured on the cover of Volume 17, Issue 11 of Aging-US was published on October 30, 2025, titled "SAMP-Score: a morphology-based machine learning classification method for screening pro-senescence compounds in p16 positive cancer cells."

1 Dec 2025

Researchers capture a ribozyme in motion for the first time

RNA is a central biological macromolecule, now widely harnessed in medicine and nanotechnology. Like proteins, RNA function often depends on its precise three-dimensional structure.

27 Nov 2025

Freezing cells for success: DMSO-free redefining the future of cryopreservation

Cryopreservation plays a crucial role in cell biology research, bioprocessing, and biomanufacturing. Traditionally, DMSO (dimethyl sulfoxide) has been the cryoprotectant of choice for preserving cells.

From NIPPON Genetics EUROPE GmbH 25 Nov 2025

Early treatment after head injury lowers long-term risk of Alzheimer’s disease

Getting treatment within one week of a serious head injury can reduce the risk of developing Alzheimer's disease by up to 41%, according to new research from Case Western Reserve University.

25 Nov 2025

Study overturns assumptions about PTPN22 risk gene’s role in interferon production

A new paper from the University of Kansas overturns the idea that a "risk gene" carried by millions of people worldwide influences production of Type 1 interferon, a workhorse of the immune system.

25 Nov 2025

Breakthrough medium transforms canine stem cells into beating cardiomyocytes

In research, induced pluripotent stem (iPS) cells are derived from skin, urine, or blood samples and developed into other cells, like heart tissue, that researchers want to study.

21 Nov 2025

New light-activated method revolutionizes creation of drug building blocks

A team of organic and computational chemists at the University of Minnesota Twin Cities have created a new, modern tool to make the process of creating pharmaceuticals and agrochemicals faster, cost-effective, and energy-efficient.

21 Nov 2025

UK Biobank releases the world’s largest metabolomic dataset for disease research

UK Biobank has today [Thursday 20 November] released the final set of data on nearly 250 metabolites – the molecules in our blood produced by our bodies as we go about our lives – in half a million volunteers.

20 Nov 2025

Evaluating whether LIT supplementation slows cognitive decline in Alzheimer’s patients

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline such as memory loss and behavioral disturbances that severely impair quality of life. Despite decades of research, effective disease-modifying therapies remain elusive, underscoring the urgent need for novel neuroprotective strategies.

19 Nov 2025

New AI investment aims to accelerate the search for an effective HIV vaccine

As of 2024, over 40 million people in the world are diagnosed with human immunodeficiency virus (HIV)-a chronic, life-threatening infection that remains one of the leading global causes of death.

18 Nov 2025

Scientists urge careful evaluation before applying AI virtual staining in healthcare workflows

Artificial intelligence has exploded in popularity in recent years, and many proponents are excited about its potential uses in medicine: for example, processing samples quickly or identifying markers of disease that may be missed by the human eye.

18 Nov 2025

Groundbreaking mouse cortex model opens new frontiers in neuroscience

Harnessing the muscle of one of the world's fastest supercomputers, researchers have built one of the largest and most detailed biophysically realistic brain simulations of an animal ever.

17 Nov 2025

Transforming colorectal cancer research with patient-derived xenograft models

Patient-derived xenograft (PDX) models are emerging as a transformative tool in colorectal cancer (CRC) research, offering unparalleled insights into tumor biology, drug resistance, and personalized treatment approaches.

14 Nov 2025

New study reveals how the uterus senses force to drive labor

When labor begins, the uterus must coordinate rhythmic, well-timed contractions to deliver the baby safely.

13 Nov 2025

Cellarity's AI model predicts drug-induced liver injury

Cellarity, a clinical-stage biotechnology company developing Cell State-Correcting therapies through integrated multi-omics and AI modeling, today announced the publication of a seminal manuscript in Nature Communications, which describes a novel framework for the prediction and characterization of drug-induced liver injury (DILI), along with open-source posting of the model and validation data.

13 Nov 2025

TRIMTECH Therapeutics appoints Dr Mike Hutton to Scientific Advisory Board

TRIMTECH Therapeutics, a biotech company creating novel, small molecule therapeutics that selectively degrade protein aggregates, to combat neurodegenerative diseases, today announced the appointment of Dr Mike Hutton to its Scientific Advisory Board (SAB).

From TRIMTECH Therapeutics 12 Nov 2025