Hybridization News and Research

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Individualized therapies targeting specific features show promise in transforming cancer treatment

Individualized therapies that target the specific genetic features of tumors have the potential to transform cancer diagnosis, treatment and care.

10 Sep 2018

New assay may help improve both sarcoma diagnosis and treatment

Sarcomas are rare tumors that are often misdiagnosed. Specific recurrent chromosomal rearrangements, known as translocations, can serve as essential diagnostic markers and are found in about 20 percent of sarcomas.

20 Aug 2018

OGT announces launch of updated SureSeq Interpret NGS analysis software

Oxford Gene Technology, The Molecular Genetics Company, has announced the launch of the eagerly-anticipated update to its SureSeq Interpret software, included with purchases of SureSeq NGS panels.

From Oxford Gene Technology 10 Aug 2018

Study finds false negatives in common tests used to determine ROS1 status in lung cancer

Drugs like crizotinib are used to treat patients with ROS1-positive lung cancer. But which patients are ROS1-positive? A University of Colorado Cancer Center study published in the Journal of Thoracic Oncology shows that common laboratory tests used to determine ROS1 status all have inherent limitations that can lead to false-negative results.

9 Aug 2018

OGT announces direct sales and support services in Europe

Oxford Gene Technology, The Molecular Genetics Company, has announced that it is now directly selling Cytocell Fluorescence In Situ Hybridisation products through several established affiliates of SysmexCorporation in Europe following its acquisition last year.

From Oxford Gene Technology 4 Jul 2018

OGT increases NGS cancer panel content to provide more flexibility for customization

Oxford Gene Technology, The Molecular Genetics Company, has expanded its SureSeq myPanel™ NGS Custom Cancer Panel content - now covering 120 fully optimized cancer related genes.

From Oxford Gene Technology 13 Jun 2018

New guideline for HER2 testing in breast cancer benefits patients and clinicians

Published today, a Focused Update to the American Society of Clinical Oncology/College of American Pathologists guideline for human epidermal growth factor receptor 2 (HER2) testing in breast cancer brings new levels of clarity that will benefit patients and clinical teams alike.

31 May 2018

Lunaphore and Vitro announce partnership to develop ISH protocols for RNA, DNA targets

Lunaphore Technologies SA, a next generation tissue diagnostics company, and Vitro SA, a manufacturer in the field of Pathology and Biomedical Research, announce today a collaboration agreement to develop In Situ Hybridization protocols for RNA and DNA targets in tissue using reagents provided by Vitro on Lunaphore’s rapid autostaining platform.

25 May 2018

Study uncovers mechanism underlying brain malformation linked to severe epilepsy

One of the most frequent causes of drug-resistant epilepsy, considered a difficult disease to control, is a brain malformation known as focal cortical dysplasia.

16 May 2018

Bio-Techne expands automation capabilities of popular RNAscope ISH technology

Bio-Techne has expanded the automation capabilities of its popular Advanced Cell Diagnostics -branded RNAscope in situ hybridization technology with the launch of several new and updated assays.

From Bio-Techne 18 Apr 2018

Oxford Gene Technology announces leadership changes

Oxford Gene Technology, The Molecular Genetics Company, has announced that on 1st April 2018 Dr John Anson who has been with the company since 2006 as EVP of R&D took over as CEO from Dr Mike Evans, who has become a non-executive director of OGT’s board.

From Oxford Gene Technology 10 Apr 2018

Researchers develop way to sequence entire fetal genome by modifying prenatal testing method

For the first time, researchers have developed a way to sequence the entire genome of a fetus by modifying the prenatal testing method known as amniocentesis.

16 Mar 2018

OGT launches new, easy-to-use Cytocell FISH probes website

Oxford Gene Technology, The Molecular Genetics Company, has launched a new version of its Cytocell fluorescence in situ hybridization probes website - designed to provide a wealth of information and advice, offer refined functionality, and be easy-to-use.

From Oxford Gene Technology 8 Mar 2018

Telomere length testing can alter treatment decisions for certain diseases

Research led by Johns Hopkins physicians and scientists shows that a test for measuring the length of DNA endcaps, called telomeres, which has a variability rate of 5 percent, can alter treatment decisions for patients with certain types of bone marrow failure.

27 Feb 2018

Novel gene expression analysis technique can accurately and quickly measure RNA

A University of Illinois and Mayo collaboration has demonstrated a novel gene expression analysis technique that can accurately measure levels of RNA quickly and directly from a cancerous tissue sample while preserving the spatial information across the tissue --something that conventional methods cannot do.

18 Jan 2018

Oncologists find new biomarker for breast cancer having poor prognosis

With the support of the FWF, an oncologist found a biomarker for breast cancer having a poor prognosis and developed two viable methods to detect it in tissue samples.

22 Nov 2017

Scientists develop novel technology that uses CRISPR to map genetic mutations

A team of scientists led by Virginia Commonwealth University physicist Jason Reed, Ph.D., have developed new nanomapping technology that could transform the way disease-causing genetic mutations are diagnosed and discovered.

21 Nov 2017

BWH researchers identify new rare genetic cause of peritoneal mesothelioma

Mesothelioma is a rare and aggressive tumor that, in many cases, results from exposure to asbestos. But over the last several decades, other causes of the disease have emerged, including treatment with high-intensity therapeutic radiation and, more recently, an inherited genetic mutation.

14 Sep 2017

Penn researchers find abnormally shortened telomeres in young DMD patients’ muscle stem cells

Researchers from the Perelman School of Medicine at the University of Pennsylvania have made a discovery about muscular dystrophy disorders that suggest new possibilities for treatment.

7 Sep 2017

Researchers decode complex finger millet genome in high quality for first time

Finger millet has two important properties: The grain is rich in important minerals and resistant towards drought and heat.

5 Sep 2017