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Temporal changes in CD4 T-lymphocyte dynamics upon immunization against SARS-CoV-2 spike protein

Researchers assessed changes in CD4 T-lymphocyte temporal dynamics by evaluating T-lymphocyte responses to SARS-CoV-2 S using Foxp3-Tocky mice and Nr4a3-Tocky mice.

27 Jul 2022

Tunneling nanotubes can assist SARS-CoV-2 propagation

A new study found that tunneling nanotubes (TNTs) offer a pathway for SARS-CoV-2 neuronal spreading.

26 Jul 2022

Oligomeric molecular structure of the MOR-Gal1R complex revealed

A study published in the journal Pharmacological Research reveals the oligomeric molecular structure of the MOR-Gal1R complex, a component present in the brain which is involved in the analgesic and addictive effects of certain opioids.

22 Jul 2022

Study may help overcome some obstacles to the development of nanoparticle-based drugs

Using nanoparticles to deliver cancer drugs offers a way to hit tumors with large doses of drugs while avoiding the harmful side effects that often come with chemotherapy.

21 Jul 2022

Pigment epithelium-derived factor ablations may lead to eye aging

Researchers identified that loss of pigment epithelium-derived factor (PEDF) may cause aging in the eye.

21 Jul 2022

Scientists explore guanine-specific pocket in SARS-CoV-2 nucleocapsid protein of therapeutic value against multiple coronaviruses

Researchers studied open and closed conformations of the C-terminal of SARS-CoV-2 nucleocapsid (N) protein termed the NCTD.

19 Jul 2022

Tokyo Tech researchers develop the first synthetic mechanosensitive potassium channel

Intrigued by the properties of ion channel proteins commonly observed in cells, Tokyo Tech researchers have developed the first synthetic mechanosensitive potassium channel using a newly developed aromatic fluorinated amphiphilic cyclophane.

15 Jul 2022

New chemical biological tools could help better understand the progression of Parkinson's disease

Researchers are a step closer to understanding how Parkinson's disease develops and progresses thanks to chemical biological tools developed at Simon Fraser University.

13 Jul 2022

TRIM7 inhibits coxsackievirus and norovirus infection

In a recent study posted to the bioRxiv* preprint server, researchers elucidated the underlying mechanisms of tripartite motif containing 7 (TRIM7) activity against coxsackievirus and norovirus.

7 Jul 2022

Chicoric acid a potential candidate for COVID-19 treatment

An article under review in the Scientific Reports journal and currently available on the Research Square* preprint server reports on chicoric acid (CA) as a potential inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

6 Jul 2022

Study offers insights into potentially problematic interactions between viruses and live vaccines

A study of a herpes virus that infects chickens offers new insights into potentially problematic interactions between vaccines made from live viruses and the viruses they are meant to thwart.

6 Jul 2022

MIT chemists discover how changes in a shape-shifting receptor trigger cell growth

Receptors found on cell surfaces bind to hormones, proteins, and other molecules, helping cells respond to their environment.

6 Jul 2022

Paxlovid resistance associated with SARS-CoV-2 3CLpro mutations

In a recent study published in the bioRxiv* preprint server, researchers at the Medical University of Innsbruck assessed the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 3CLpro mutations responsible for Paxlovid resistance. The 3-chymotrypsin-like protease (3CLPro), or main protease (Mpro), is the main protease found in coronaviruses.

6 Jul 2022

Scientists discover how a protein and enzymes interact to allow hepatitis A virus replication

The viral replication cycle is crucial for a virus to spread inside the body and cause disease. Focusing on that cycle in the hepatitis A virus (HAV), UNC School of Medicine scientists discovered that replication requires specific interactions between the human protein ZCCHC14 and a group of enzymes called TENT4 poly(A) polymerases.

4 Jul 2022

Enteric viruses found to transmit through the salivary route

Researchers reported on the productive and persistent infection of salivary glands (SGs) by enteric viruses, with oral cavity titers similar to intestinal titers.

4 Jul 2022

New K+-sensitive dual-mode imaging probe for diagnosis of tumor malignancy

Tumor malignancy identification plays an essential role in clinical management of cancer. Currently, biopsy is the gold standard for malignancy identification in most tumor cases, it is, however, invasive that can cause great discomfort to patients, and potentially increase the risk of distant metastases due to the complex sampling process.

1 Jul 2022

Somatic hypermutations found to enhance humoral immunity against SARS-CoV-2 variants

Researchers explored the molecular basis for increased immunity against heterologous SARS-CoV-2 strains after repeated antigen exposures.

1 Jul 2022

The identification and characterization of a thermophilic Cas13a ortholog highly active at the temperatures required for RT-LAMP

Researchers developed a new detection assay for SARS-CoV-2.

1 Jul 2022

SARS-CoV-2 can evade Paxlovid by multiple mechanisms

In a recent article posted to the bioRxiv* preprint server, researchers at Rutgers, the State University of New Jersey, the University of South Florida, and the Catholic University of America demonstrated that the natural severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) mutations result in nirmatrelvir resistance.

30 Jun 2022

Optical fiber holds promise for use in deep-tissue studies of patients’ brains with Alzheimer’s disease

An optical fiber as thin as a strand of hair holds promise for use in minimally invasive deep-tissue studies of patients' brains that show the effects Alzheimer's disease and other brain disorders.

30 Jun 2022

Fluorescence News and Research

Temporal changes in CD4 T-lymphocyte dynamics upon immunization against SARS-CoV-2 spike protein

Tunneling nanotubes can assist SARS-CoV-2 propagation

Oligomeric molecular structure of the MOR-Gal1R complex revealed

Study may help overcome some obstacles to the development of nanoparticle-based drugs

Pigment epithelium-derived factor ablations may lead to eye aging

Scientists explore guanine-specific pocket in SARS-CoV-2 nucleocapsid protein of therapeutic value against multiple coronaviruses

Tokyo Tech researchers develop the first synthetic mechanosensitive potassium channel

New chemical biological tools could help better understand the progression of Parkinson's disease

TRIM7 inhibits coxsackievirus and norovirus infection

Chicoric acid a potential candidate for COVID-19 treatment

Study offers insights into potentially problematic interactions between viruses and live vaccines

MIT chemists discover how changes in a shape-shifting receptor trigger cell growth

Paxlovid resistance associated with SARS-CoV-2 3CLpro mutations

Scientists discover how a protein and enzymes interact to allow hepatitis A virus replication

Enteric viruses found to transmit through the salivary route

New K+-sensitive dual-mode imaging probe for diagnosis of tumor malignancy

Somatic hypermutations found to enhance humoral immunity against SARS-CoV-2 variants

The identification and characterization of a thermophilic Cas13a ortholog highly active at the temperatures required for RT-LAMP

SARS-CoV-2 can evade Paxlovid by multiple mechanisms

Optical fiber holds promise for use in deep-tissue studies of patients’ brains with Alzheimer’s disease

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