Neurodegenerative Diseases News and Research

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Enhanced Genomics and The ALBORADA Drug Discovery Institute partner to accelerate Alzheimer's drug discovery

Enhanced Genomics ('Enhanced'), the biotechnology company pioneering 3D multi-omics to rapidly identify high-confidence, genetically validated drug targets for common diseases, today announced a strategic partnership with The ALBORADA Drug Discovery Institute at the University of Cambridge.

25 Jun 2025

Protective gene variant slows Alzheimer’s by taming brain inflammation

A rare gene mutation that delays Alzheimer's disease does so by damping inflammatory signaling in brain-resident immune cells, according to a preclinical study led by investigators at Weill Cornell Medicine.

23 Jun 2025

Assessment of insulin resistance using TyG index flags rapid cognitive decline in Alzheimer's patients

Insulin resistance detected by routine triglyceride-glucose (TyG) index can flag people with early Alzheimer's who are four times more likely to present rapid cognitive decline, according to new research presented at the European Academy of Neurology (EAN) Congress 2025.

22 Jun 2025

New 3D immunohistochemistry method enhances deep tissue imaging

Three dimensional immunohistochemistry (3D-IHC) has transformed our ability to visualize the spatial arrangement of cells and molecules in intact tissues.

19 Jun 2025

T cells play key role in early stages of Parkinson’s disease

Your T cells work hard to fight disease. Unfortunately, "friendly fire" from T cells can sometimes harm the body's healthy tissues.

19 Jun 2025

Uppsala researchers create 3D-printed human nerve tissue model

With the aid of a 3D printer, researchers at Uppsala University have succeeded in creating a model that resembles human nerve tissue.

18 Jun 2025

Kupffer cell reprogramming in embryos explains metabolic disorders in offspring

Children born to obese mothers are at higher risk of developing metabolic disorders, even if they follow a healthy diet themselves.

18 Jun 2025

Living near algal blooms linked to faster ALS progression

Living close to cyanobacterial harmful algal blooms - which are present nationwide but are more common in coastal and Great Lake states - heightens the rate of dying from amyotrophic lateral sclerosis, or ALS, a study suggests.

17 Jun 2025

New computational tool uncovers hidden genetic mutations in proteins

Scientists at UCLA and the University of Toronto have developed an advanced computational tool, called moPepGen, that helps identify previously invisible genetic mutations in proteins, unlocking new possibilities in cancer research and beyond.

16 Jun 2025

Researchers identify cellular hotspots that trigger ferroptosis

Researchers at the VIB-KU Leuven Center for Cancer Biology have uncovered how a unique interaction between two cellular compartments, namely the endoplasmic reticulum (ER) and mitochondria, can act as a central ignition point for ferroptosis, a form of cell death driven by lipid oxidation and iron.

14 Jun 2025

Yellow pigment linked to protection against severe malaria

New research suggests that a pigment that causes yellowing of the skin, or jaundice, may help protect people from the most severe consequences of malaria.

13 Jun 2025

New large-scale study maps early triggers of Alzheimer’s protein aggregation

A new large-scale study has mapped the first molecular events that drive the formation of harmful amyloid protein aggregates found in Alzheimer's disease, pointing towards a new potential therapeutic target.

12 Jun 2025

How Parkinson’s disease affects emotion recognition of voices

A new study in Neurodegenerative Diseases looks closely at how Parkinson’s disease can affect something as everyday and essential as recognizing emotion in someone’s voice.

From S. Karger AG 11 Jun 2025

Using causal machine learning to identify potential ALS treatments

Potential treatments for amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases may already be out there in the form of drugs prescribed for other conditions.

10 Jun 2025

Symptom asymmetry influences how Parkinson’s patients process emotions

New study shows dopamine treatments and symptom asymmetry impact patients differently.

10 Jun 2025

Research reveals the brain’s hidden shield against aging and neurodegeneration

In a compelling Genomic Press Interview published today in Brain Medicine, Sophia Shi, PhD, unveils her pioneering research that fundamentally changes our understanding of brain aging and opens revolutionary therapeutic pathways for Alzheimer's disease and related neurodegenerative conditions.

10 Jun 2025

Brain-computer interfaces signal a new era in neurosurgery and neurorehabilitation

Brain-computer interface (BCI) technology is opening an unprecedented chapter in human-machine integration by establishing direct communication between the brain and external devices.

10 Jun 2025

What happens to your body and mind during a five-day water fast?

A five-day water-only fast led to significant weight, fat, and lean muscle loss in middle-aged women, along with improved mood and marked changes in metabolic and inflammatory markers. The study also found that psychological traits like emotional intelligence and impulsivity influenced the amount of fat and muscle lost during fasting.

9 Jun 2025

Late-life mood disorders may signal neurodegenerative diseases

Depression and bipolar disorder of late onset may represent more than just mental health conditions. Growing evidence suggests these late-life mood disorders (LLMDs) could be not merely risk factors, but rather early warning signs of neurodegenerative diseases like dementia, even when they appear years before memory loss or other cognitive symptoms become apparent.

9 Jun 2025

Scientists identify genetic clues linking air pollution to neurodegeneration

This review highlights how air pollution and occupational inhalation exposures may contribute to neurodegenerative disorders by triggering epigenetic changes. The authors stress the urgent need for advanced research to identify early biomarkers and guide protective health strategies for high-risk populations.

6 Jun 2025