Anaphylaxis News and Research

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Anaphylaxis is an acute multi-system severe type I hypersensitivity reaction. Due in part to the variety of definitions, between 1% and 15% of the population of the United States can be considered "at risk" for having an anaphylactic reaction if they are exposed to one or more allergens. Of those people who actually experience anaphylaxis, up to 1% may die as a result.

New studies shine light on oral immunotherapy and oral food challenges in allergic children

Two new studies being presented at the American College of Allergy, Asthma and Immunology (ACAAI) Annual Scientific Meeting in Orlando shine a spotlight on oral immunotherapy and oral food challenges (OFCs) in children, showing that both procedures are safe for young patients and can be life-changing for families navigating food allergies.

6 Nov 2025

COVID-19 vaccination may have broader health benefits for children with atopic dermatitis

Children with atopic dermatitis (AD), commonly known as eczema, may experience fewer infections and allergic complications if they receive the COVID-19 vaccine, according to new research being presented at the 2025 American College of Allergy, Asthma and Immunology (ACAAI) Annual Scientific Meeting in Orlando.

6 Nov 2025

Long-term study shows peanut patch treatment builds tolerance in toddlers

New research presented at the 2025 Annual Scientific Meeting of the American College of Allergy, Asthma and Immunology (ACAAI) offers encouraging news for parents of young children with peanut allergies.

6 Nov 2025

Anaphylaxis antidote underprescribed for schoolchildren in England

Less than half of schoolchildren in England who are at risk of a serious and potentially life-threatening allergic reaction (anaphylaxis) to food were prescribed the antidote-an adrenaline [epinephrine] autoinjector, or AAI for short-finds an analysis of national prescribing data, published online in the Archives of Disease in Childhood.

22 Oct 2025

First-generation antihistamines increase delirium risk in older hospitalized patients

An analysis in the Journal of the American Geriatrics Society reveals that older inpatients admitted to physicians who prescribe higher amounts of first-generation antihistamines face an elevated risk of delirium while in the hospital.

22 Oct 2025

Asthma and multiple allergies raise the risk of failed oral food challenges

Research shows asthma and multi-food allergies elevate the odds of reactions in oral food challenges, emphasizing the importance of careful patient selection.

8 Oct 2025

How gluten harms some people but helps others

New insights reveal gluten's health potential, highlighting beneficial peptides and innovative methods to enhance wheat safety for sensitive individuals.

3 Oct 2025

Intranasal adrenaline can be as effective as the EpiPen

Instead of stabbing yourself, or someone else, in the thigh with a needle to deliver a dose of adrenaline to counter anaphylactic shock, would it not be easier to use a nasal spray instead?

30 Sep 2025

Mediterranean diet during pregnancy cuts babies’ food allergy risk

Researchers found that mothers who closely followed a Mediterranean diet during pregnancy and breastfeeding had infants with lower odds of developing food allergies. High fruit, vegetable, and full-fat dairy intake appeared protective, while higher poultry, red meat, and fish intake during pregnancy increased risk.

15 Sep 2025

UC researcher wins $300,000 grant to investigate the underlying causes of eosinophilic esophagitis

Patients with eosinophilic esophagitis (EoE) often describe the condition as painful, disruptive and frightening.

11 Sep 2025

Gut mast cells produce key molecules driving food allergy anaphylaxis

Food allergies affect more than half a billion people worldwide. In severe cases, even a small bite of the wrong food can trigger anaphylaxis - a rapid, body-wide allergic reaction that can cause difficulty breathing, a dangerous drop in blood pressure and even death.

28 Aug 2025

New study expands the list of foods causing anaphylaxis

The European Regulation list on mandatory labelling of foods includes 14 allergenic foods. Research published in Clinical & Experimental Allergy has identified eight additional foods frequently involved in food-induced anaphylaxis.

21 Aug 2025

Asthma drug found to prevent food allergy reactions in mice

A drug already FDA-approved for asthma was found to nearly eliminate life-threatening allergic reactions to food allergens in mice - a breakthrough that could lead to new protection for millions of people living with food allergies, reports a new Northwestern Medicine study.

7 Aug 2025

New clues to how food allergies trigger anaphylaxis

New research in mice reveals that food-induced anaphylaxis is driven by distinct immune pathways involving inflammatory lipids called leukotrienes.

7 Aug 2025

Uncovering how a key inflammatory molecule causes esophageal smooth muscle contractions

A research group led by Dr. Keisuke Obara, Dr. Kento Yoshioka, and Professor Yoshio Tanaka from the Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, has uncovered important details about how platelet-activating factor (PAF)-a powerful molecule involved in inflammation and allergic reactions-triggers contractions in the smooth muscles of the esophagus.

9 Jul 2025

Early allergen introduction reduces childhood food allergy risk

Investigating allergy prevention, this research highlights early intervention strategies and the promise of biologic treatments in managing allergic conditions.

29 May 2025

Understanding cow’s milk allergy in breastfed infants

Cow’s milk allergy (CMA) affects up to 2.2% of infants, with a complex interplay of immunological mechanisms, allergen transfer via breast milk, and variable responses to maternal elimination diets. Current evidence challenges the routine use of maternal dietary restrictions, highlighting the need for precise diagnosis and further research.

27 May 2025

Beckman Coulter Life Sciences launches safer, Next-Generation Basophil Activation Test to improve, expedite allergy research

Beckman Coulter Life Sciences, a global leader in laboratory automation and innovation, introduces the Next-Generation Basophil Activation Test (BAT) for research use only to more effectively characterize food allergies without exposure to potentially harmful allergens.

From Beckman Coulter Life Sciences - Flow Cytometry 8 Apr 2025

Common medicines contain hidden gluten and soy, study finds

A Portuguese study found that over half of paracetamol-based painkillers and a quarter of ibuprofen liquids contain gluten or soy-derived excipients, posing risks for allergy-sensitive individuals.

1 Apr 2025

Scientists link emulsifiers in processed foods to allergy and immune disorders

Review identifies common food additives in ultra-processed foods—particularly emulsifiers like carrageenan and polysorbate 80—as key drivers of gut dysbiosis, inflammation, and allergic diseases by disrupting intestinal barriers and activating proinflammatory pathways.

26 Mar 2025