Metabolite News and Research

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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.

Exposure to fungicides and insecticides alters onset of puberty in girls

The study, which tracked more than 500 Spanish girls between the ages of 7 and 10, links the presence of certain fungicides in urine to early menarche and that of the insecticide chlorpyrifos to delayed menarche, highlighting the impact of pesticides on pubertal development.

31 Jul 2026

Biotherapeutic metabolite repairs gut damage caused by HIV infection

Researchers at the UC Davis School of Medicine have identified a naturally occurring metabolite that repairs gut damage caused by HIV infection and significantly improves the effectiveness of antiretroviral therapy (ART) in the nonhuman primate model of HIV/AIDS.

30 Jul 2026

Study uncovers biological differences behind co-occurring conditions of Down syndrome

In a groundbreaking new study published in Nature Communications, researchers from the University of Colorado Anschutz Linda Crnic Institute for Down Syndrome (Crnic Institute) discovered unique biological processes altered among individuals with Down syndrome who have different sets of co-occurring conditions.

23 Jul 2026

Evidence shows artificial sweeteners cannot be judged as a single group

This narrative review found that non-nutritive artificial sweeteners have compound-specific and context-dependent associations with gut microbiota, metabolism, and health-related outcomes. Evidence does not support treating all sweeteners as uniformly harmful or safe, with human findings often limited or inconsistent.

23 Jul 2026

Spermidine boosts key cellular processes linked to aging in early research

This review finds that spermidine supports autophagy, mitochondrial function, and healthspan in experimental models, while observational studies link higher dietary intake to lower mortality. However, human trials have produced limited and mixed results, leaving its clinical role in healthy aging unresolved.

23 Jul 2026

Moderate coffee intake may support heart health, AHA says

The American Heart Association finds that habitual coffee consumption is associated with lower risks of several cardiovascular outcomes, although most evidence comes from observational studies. Moderate intake is generally safe for most adults, while energy drinks and individual caffeine sensitivity may increase cardiovascular concerns.

21 Jul 2026

Gut microbial metabolites may shape vulnerability to stress-related mental disorders

Gut microbiome-derived metabolites may influence stress-related mental disorders through neural, immune, endocrine, and epigenetic pathways. Evidence is strongest for depression and preclinical models, while larger longitudinal human studies are needed to establish causality and clinical value.

20 Jul 2026

Genome-mining tool reveals new antibiotic hidden in a silent gene cluster

Researchers developed DiscERN, a genome-mining platform that combines four complementary algorithms to identify evolutionarily related biosynthetic gene clusters and prioritize candidates for experimental study. The approach revealed discomycin A, a previously unknown calcium-dependent lipopeptide antibiotic with potent activity against several Gram-positive bacteria.

15 Jul 2026

Study links gut microbes to stronger cancer immunotherapy responses

A new study from a team including University of Nebraska–Lincoln researchers is the first to show metabolites produced by certain bacteria in the gut can positively impact the body's immune response to cancer.

14 Jul 2026

Newborn breathing collapse risk highest in first 24 hours

Sudden unexpected postnatal collapse (SUPC) occurs when an apparently healthy newborn suddenly stops breathing and collapses during the first week of life.

14 Jul 2026

Novogene Europe launches Untargeted Metabolomics Service at Cambridge Omics Centre

Novogene Europe, a multiomics research services partner, today announced that it has strengthened its position as a multiomics partner with the launch of its Untargeted Metabolomics Service through its Cambridge Omics Centre.

From Novogene Europe 13 Jul 2026

Study links PTSD to accelerated biological aging and chronic disease

Post-Traumatic Stress Disorder (PTSD) remains a common condition affecting World Trade Center (WTC) responders 25 years after the attack on the Twin Towers.

8 Jul 2026

Microbiome science merges with oncology for better cancer treatments

Cancer remains notoriously difficult to treat, partly because tumors co‑opt their surrounding environment, including the resident microbiota, to evade immune surveillance and resist conventional therapies.

7 Jul 2026

Blood markers reveal metabolic impact of ultra-processed food consumption

Consumption of ultra-processed food (UPF) results in a distinct metabolic 'signature' in the blood, associated with potentially adverse health conditions, a new study by an international team of researchers finds.

6 Jul 2026

Psychological stress accelerates immune aging through the gut microbiota

Psychological stress is increasingly recognized as a risk factor for certain health conditions including cardiovascular disease and diabetes, especially when paired with an impaired immune response.

2 Jul 2026

Probiotic metabolite found to suppress melanoma tumor growth in mice

Immune checkpoint inhibitors like anti-PD-1 have transformed melanoma treatment, yet more than half of patients fail to respond or eventually develop resistance.

30 Jun 2026

Fourier 80: bringing benchtop NMR systems to the laboratory

Benchtop NMR puts nuclear magnetic resonance on the lab bench, supporting teaching, QC, reaction monitoring, and materials research.

From Bruker BioSpin Group 30 Jun 2026

Blood metabolism maps how lifestyle tracks function in cognitive aging

A new study used pathway-level blood metabolomics to identify lifestyle-associated metabolic patterns linked to physical, cognitive, and daily functional performance across CN, MCI, and AD. The findings suggest that diet- and activity-linked pathway signals span energy, amino acid, lipid, inflammatory, oxidative stress, and microbiome-related metabolism, but require independent and longitudinal validation.

29 Jun 2026

Gut microbes emerge as potential players in estrogen-driven cancers

A new review maps how the endocrine-microbiome axis expands the estrobolome concept, showing that gut microbes may alter estrogen recycling, produce hormone-like metabolites, and shape inflammation and tissue environments in hormone-driven cancers. Human evidence remains mostly associative, so the authors call for causal models, longitudinal multi-omics, multi-kingdom profiling, and sex-stratified studies before microbiome-guided cancer strategies enter routine care.

25 Jun 2026

Blood metabolites reveal lifestyle links to brain health before dementia

Blood metabolome profiling in dementia-free middle-aged adults linked 14 metabolites to cognition and 22 metabolites to MRI markers of brain health. Lifestyle, clinical factors, medication use and gut microbiota appeared to shape many of these metabolites, with ergothioneine emerging as a notable cognition-linked signal.

25 Jun 2026