Peripheral Artery Disease News and Research

RSS

Peripheral arterial disease (PAD) occurs when leg arteries become narrowed or blocked by plaque. These blockages can result in severe pain for patients, limited physical mobility, and life-threatening non-healing leg ulcers. According to the American Heart Association, this condition affects approximately 8 to 12 million Americans. With only about 25 percent of PAD patients undergoing treatment, it is a disease that is largely under-diagnosed and under-treated. If left untreated, PAD can lead to critical leg ischemia, a condition where not enough blood is being delivered to the leg to keep the tissue alive. Total loss of circulation to the legs and feet can cause gangrene and lead to amputation.

New data supports earlier use of evolocumab in high-risk diabetes

Adding the PCSK9 inhibitor evolocumab to a high-intensity, cholesterol-lowering regimen reduced the risk of a first major cardiovascular event among adults with atherosclerotic cardiovascular disease (ASCVD) or diabetes , according to a preliminary late-breaking science presentation today at the American Heart Association's Scientific Sessions 2025.

11 Nov 2025

Study reports increase in leg and foot amputations in Illinois hospitals from 2016 to 2023

Rates of leg and foot amputations in Illinois hospitals increased 65% between 2016 and 2023, reports a new Northwestern Medicine study.

31 Oct 2025

Semaglutide protects the heart beyond weight loss, SELECT trial shows

Semaglutide lowered the risk of major adverse cardiovascular events across all body weight and waist circumference levels in people with overweight or obesity and cardiovascular disease. Early waist reduction explained only a third of this benefit, showing that semaglutide’s heart protection extends beyond fat loss.

26 Oct 2025

Novel RNA target offers hope for improving outcomes in patients with chronic limb ischemia

Mark W. Feinberg, MD, cardiologist with the Mass General Brigham Heart and Vascular Institute and professor of medicine at Harvard Medical School, is the senior author of a paper published in the Journal of Clinical Investigation, "A smooth muscle cell lncRNA controls angiogenesis in chronic limb-threatening ischemia through miR-143-3p/HHIP signaling."

13 Sep 2025

Cardiovascular screening in men aged 60 to 64 years does not reduce all-cause mortality

An invitation to attend a comprehensive screening examination for the early signs of cardiovascular disease (CVD) did not reduce all-cause death among men aged 60 to 64 years, according to late-breaking research presented in a Hot Line session today at ESC Congress 2025.

2 Sep 2025

Drug-coated devices not associated with improved outcomes in patients with peripheral artery disease

Drug-coated stents and balloons were not associated with reduced risk of amputation or improved quality of life compared with uncoated devices in two trials in peripheral artery disease (PAD), according to late-breaking research presented in a Hot Line session today at ESC Congress 2025.

1 Sep 2025

Adding aspirin raises cardiovascular events in high-risk CCS patients on anticoagulants

Adding aspirin increased the risk of cardiovascular events, death and major bleeding in high-risk patients with chronic coronary syndrome (CCS) who had prior stenting and were receiving long-term chronic oral anticoagulation (OAC), according to late-breaking research presented in a Hot Line session today at ESC Congress 2025 and simultaneously published in New England Journal of Medicine.

1 Sep 2025

Ivabradine fails to prevent myocardial injury after noncardiac surgery in large clinical trial

Ivabradine did not reduce the occurrence of myocardial injury after noncardiac surgery (MINS), according to late-breaking research presented in a Hot Line session today at ESC Congress 2025.

1 Sep 2025

Genetic variants mimicking IL-6 inhibition linked to lower cardiovascular risk

People with lower interleukin-6 activity have a reduced risk of cardiovascular diseases, a new LMU study reveals.

26 Aug 2025

Impaired blood flow alters immunity and fuels tumor progression

Cutting off blood flow can prematurely age the bone marrow, weakening the immune system's ability to fight cancer, according to a new study from NYU Langone Health.

19 Aug 2025

New initiative expands screening for cardiovascular disease marker in community health centers

Elevated lipoprotein(a), also known as Lp(a), is an independent, inherited and causal risk factor for cardiovascular disease, the leading cause of death and disability worldwide.

5 Aug 2025

New project aims to boost screening for cardiovascular disease marker in community health centers

Elevated lipoprotein(a), also known as Lp(a), is an independent, inherited and causal risk factor for cardiovascular disease, the leading cause of death and disability worldwide.

23 Jul 2025

Can one drug do it all? Reviewing the expanding clinical universe of GLP-1 agonists

Landmark trials have shown that GLP-1 receptor agonists, originally developed for diabetes and weight loss, also provide significant benefits for cardiovascular, kidney, liver, joint, and sleep-related diseases. These effects extend beyond weight loss, suggesting anti-inflammatory mechanisms with broad potential for managing chronic diseases.

22 Jul 2025

A million veterans gave DNA to aid health research. Scientists worry the data will be wasted.

One of the world's biggest genetic databases comprises DNA data donated over the years by more than a million retired military service members. It's part of a project run by the Department of Veterans Affairs.

16 Jul 2025

Improving early detection of peripheral artery disease with a new diagnostic method

An alternative diagnostic method could improve early detection and treatment of peripheral artery disease (PAD), according to a new study from the University of Surrey.

10 Jul 2025

AI reveals hidden bias behind higher amputation rates in minority and rural patients

Why do rural adults and racial and ethnic minorities with vascular disease get major leg amputations more often? A new study out today in Epidemiology uses AI to solve the mystery, finding an unaccounted-for factor that researchers think points to implicit bias in the clinical decision-making process.

10 Jul 2025

SCAI publishes first clinical guidelines for managing chronic venous disease

The Society for Cardiovascular Angiography & Interventions (SCAI) has published new, evidence-based clinical practice guidelines to support the treatment of chronic venous disease (CVD), a common and often overlooked vascular condition that affects over 25 million adults in the United States.

2 Jul 2025

New guidance aims to improve blood clot prevention in chronic limb-threatening ischemia patients

A new statement from leading heart and blood vessel experts in Europe is providing clinical guidance for treatments to prevent blood clots in patients with a serious condition called chronic limb-threatening ischaemia (CLTI), after they have had procedures to restore blood flow in their lower limbs.

19 Jun 2025

Palliative care for cardiovascular conditions may help relieve symptoms and improve quality of life

Palliative care may help relieve symptoms and improve quality of life for people with cardiovascular disease and ensure that treatment is aligned with the patient's personal beliefs and values throughout all stages of illness, whether they are hospitalized in a cardiac intensive care unit or receiving outpatient care, according to a new American Heart Association scientific statement published today in the Association's flagship, peer-reviewed journal Circulation.

15 May 2025

Early cardiovascular benefits of semaglutide seen within months in SELECT trial

Semaglutide can rapidly reduce heart attacks and other serious cardiovascular complications in adults with overweight or obesity who have pre-existing cardiovascular disease but not diabetes, according to a secondary analysis of the landmark Semaglutide and Cardiovascular Outcomes (SELECT) trial from the same international author team being presented at this year's European Congress on Obesity (ECO) in Malaga, Spain.

12 May 2025

Peripheral Artery Disease News and Research

New data supports earlier use of evolocumab in high-risk diabetes

Study reports increase in leg and foot amputations in Illinois hospitals from 2016 to 2023

Semaglutide protects the heart beyond weight loss, SELECT trial shows

Novel RNA target offers hope for improving outcomes in patients with chronic limb ischemia

Cardiovascular screening in men aged 60 to 64 years does not reduce all-cause mortality

Drug-coated devices not associated with improved outcomes in patients with peripheral artery disease

Adding aspirin raises cardiovascular events in high-risk CCS patients on anticoagulants

Ivabradine fails to prevent myocardial injury after noncardiac surgery in large clinical trial

Genetic variants mimicking IL-6 inhibition linked to lower cardiovascular risk

Impaired blood flow alters immunity and fuels tumor progression

New initiative expands screening for cardiovascular disease marker in community health centers

New project aims to boost screening for cardiovascular disease marker in community health centers

Can one drug do it all? Reviewing the expanding clinical universe of GLP-1 agonists

A million veterans gave DNA to aid health research. Scientists worry the data will be wasted.

Improving early detection of peripheral artery disease with a new diagnostic method

AI reveals hidden bias behind higher amputation rates in minority and rural patients

SCAI publishes first clinical guidelines for managing chronic venous disease

New guidance aims to improve blood clot prevention in chronic limb-threatening ischemia patients

Palliative care for cardiovascular conditions may help relieve symptoms and improve quality of life

Early cardiovascular benefits of semaglutide seen within months in SELECT trial

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Latest News