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Gestational diabetes alters the placenta at the molecular level, study reveals

Gestational diabetes can cause a multitude of complications in the offspring, but to date, the reasons are incompletely understood.

18 Dec 2025

Scientists unravel how citrin deficiency can trigger fat buildup in the liver even in lean individuals

Scientists at City of Hope, one of the largest and most advanced cancer research and treatment organizations in the U.S. and a leading research center for diabetes and other life-threatening illnesses, have unraveled how citrin deficiency (CD), a rare genetic disorder that prevents the liver from converting food into energy efficiently, can trigger fat buildup in the liver - even in lean individuals.

18 Dec 2025

Folate deficiency drives genetic changes linked to lung cancer

Genetic alterations lie at the heart of cancer development, but scientists may have been overlooking a powerful driver of these changes—the everyday nutrients that feed our cells.

18 Dec 2025

Washington’s homeless hide in plain sight, growing sicker and costing taxpayers more

Every night, Abdullah Ibrahim retreats from the streets into a wooded stretch along the Potomac River.

18 Dec 2025

Music sessions aid bonding and provide respite in NICUs

Playing soothing live music in intensive care units not only helps parents bond with their baby but also provides a moment's respite from an uncertain and stressful situation, says a senior doctor in the Christmas issue of The BMJ.

18 Dec 2025

Researchers decipher anti-MOG antibody construction, paving way for therapies

MOG Antibody-associated Disease (MOGAD) is a rare autoimmune disease of the central nervous system. The blood of patients contains antibodies against myelin oligodendrocyte glycoprotein (MOG), a protein in the myelin layer that surrounds the neurons in the brain. It is believed that these antibodies contribute to the destruction of this protective layer in the brain.

18 Dec 2025

Researchers develop antibody to combat HCMV, a common, overlooked virus

Researchers at Texas Biologics have made an important discovery that could improve treatment of human cytomegalovirus (HCMV), a common but overlooked virus that poses serious risks to vulnerable populations, including people with compromised immune systems. According to the Centers for Disease Control and Prevention, the virus is the most infectious cause of birth defects in the United States.

18 Dec 2025

Many women suffer in silence from treatable pelvic floor conditions

Many women assume pelvic floor health issues are simply their fate—part of having vaginal deliveries, getting older, gaining weight or entering menopause. Perhaps they have watched their mothers and grandmothers live with symptoms, such as urinary incontinence and pain.

17 Dec 2025

High-dose rifampicin does not improve survival in tuberculosis meningitis

Each year, 11 million people worldwide develop tuberculosis, and about 1.4 million die from it. Meningitis occurs in 1–2% of patients and is the most severe complication of tuberculosis, arising when the bacteria reach the brain.

17 Dec 2025

Genetic differences can affect the effectiveness of antibody therapies

The genome differs from person to person in thousands of positions. In some cases, this means that proteins have a different building block in certain regions, rendering some antibody-based therapies ineffective, report researchers from the University of Basel, Switzerland.

17 Dec 2025

AI analysis of chest X-rays may reveal early signs of aging

Artificial intelligence may be able to reveal how fast your body is aging by analyzing a chest X-ray, according to a new study published in The Journals of Gerontology. Researchers found that a deep learning model was able to detect subtle, age-related changes in the heart, lungs, and overall health more effectively than leading DNA-based "epigenetic clocks."

17 Dec 2025

ECG-based AI model doubles early liver disease diagnoses

As rates of obesity, high blood pressure, type 2 diabetes and sleep apnea increase, cases of advanced chronic liver disease and resulting liver scarring or cirrhosis also are rising. Patients often are diagnosed based on symptoms, such as gastrointestinal bleeding, fluid retention or jaundice, which happen when liver disease has progressed to a late stage.

17 Dec 2025

Heavy menstrual bleeding linked to iron deficiency in teenage girls

More than half of teenage girls experienced heavy bleeding and 40 per cent had an iron deficiency. The research, led from Lund University in Sweden, also shows that young teenage girls who experience heavy menstrual bleeding – and are therefore at greater risk of iron deficiency – can be identified using a simple questionnaire.

17 Dec 2025

Research reveals how the gut microbiome supports successful pregnancy

Gut microbes may play a key role in training a mother's immune system to adapt to the developing fetus during pregnancy, according to a preclinical study by Weill Cornell Medicine investigators.

17 Dec 2025

Novel mRNA therapy rejuvenates immune function in aging mice

Can the weakened immune systems of older individuals be rejuvenated? Researchers from the German Cancer Research Center (DKFZ), the HI-STEM institute, and the Broad Institute have demonstrated that this is possible with an innovative approach.

17 Dec 2025

New tool can predict recurrence risk in patients with pancreatic neuroendocrine tumors

Cedars-Sinai investigators, leading a multi-institutional team, have developed and validated a tool to predict which patients with pancreatic neuroendocrine tumors (PanNETs) need closer monitoring because their cancer is more likely to recur.

17 Dec 2025

Distant astrocytes found to play a key role in spinal cord repair

Cedars-Sinai investigators have discovered a healing mechanism that could one day be harnessed to help treat patients with spinal cord injuries, stroke, and neurological conditions such as multiple sclerosis.

17 Dec 2025

Study examines fairness of oxygen desaturation thresholds in sleep apnea diagnosis

Obstructive sleep apnea (OSA) is a common sleep disorder in the U.S. affecting tens of millions, with estimates ranging from 25 to more than 80 million adults.

17 Dec 2025

Neural mechanisms underlying behavioral flexibility revealed in mice

From work meetings to first dates, it's essential to adjust our behavior for success. In certain situations, it can even be a matter of life or death.

17 Dec 2025

Brain structural changes linked to chronic PTSD in World Trade Center responders

New research among World Trade Center (WTC) responders with chronic post-traumatic stress disorder (PTSD) has uncovered measurable physical changes in their brain structure, consistent with changes in the balance of myelinated to unmyelinated neurons (fast- and slow-conducting nerve cells) across both hemispheres of the brain.

17 Dec 2025