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Using two different viruses to tackle tumors

An international research group led by the University of Basel has developed a promising strategy for therapeutic cancer vaccines.

3 Mar 2021

Pharmacists discover active substances that block SARS-CoV-2 replication

A research team of pharmacists at the University of Bonn has discovered two families of active substances that can block the replication of the SARS-CoV-2 coronavirus. The drug candidates are able to switch off the the key enzyme of the virus, the so-called main protease.

3 Mar 2021

Analytical Mass Spectrometry: How Did We Get Here, Where are We Going?

News-Medical interviews Rick Yost, winner of the Pittsburgh Analytical Chemistry Award 2021, about his research into mass spectrometry.

From Pittcon 3 Mar 2021

How SARS-CoV-2 proteins affect vascular functionality

The study, published on the pre-print server medRxiv, can pinpoint and isolate how each of the SARS-CoV-2 proteins independently affects the endothelial response and directly gauge endothelial functionality.

3 Mar 2021

Scientists reprogram a common bacterium to make designer sugar-based drug

Envisioning an animal-free drug supply, scientists have - for the first time - reprogrammed a common bacterium to make a designer polysaccharide molecule used in pharmaceuticals and nutraceuticals.

2 Mar 2021

Biological activity-based modeling offers a new approach for drug discovery

Assessing a drug compound by its activity, not simply its structure, is a new approach that could speed the search for COVID-19 therapies and reveal more potential therapies for other diseases.

2 Mar 2021

New, revolutionary theory for understanding brain and memory function

Research from the University of Kent has led to the development of the MeshCODE theory, a revolutionary new theory for understanding brain and memory function.

1 Mar 2021

New method boosts research efforts to eradicate cancer at its source

A new method, described in a study published today in the journal Nature Communications, has the potential to boost international research efforts to find drugs that eradicate cancer at its source.

1 Mar 2021

SARS-CoV-2 modulates host cell central carbon metabolism for reproduction

A team of scientists from Sweden and India has recently characterized the host cell metabolic alterations associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Their findings reveal that SARS-CoV-2 modulates the host cell's central carbon metabolism to facilitate replication and infection propagation.

28 Feb 2021

Scientists develop a simple method to make drug precursor

Save your silver! It's better used for jewelry than as a catalyst for drugs. Rice University scientists have developed a greatly simplified method to make fluoroketones, precursors for drug design and manufacture that typically require a silver catalyst.

27 Feb 2021

Study: Heart problems cause disturbed gene activity in the brain's memory center

Heart problems cause disturbed gene activity in the brain's memory center, from which cognitive deficits arise.

27 Feb 2021

New device accelerates transdermal penetration of drug molecules and extraction of interstitial fluid

A pain-free, organic and biodegradable drug delivery patch may be on the horizon for home health care patients soon.

26 Feb 2021

New approach harnesses disease-causing proteins to combat cancer

Over many decades now, traditional drug discovery methods have steadily improved at keeping diseases at bay and cancer in remission. And for the most part, it's worked well.

26 Feb 2021

Researchers study how glycans activate SARS-CoV-2

One thing that makes SARS-CoV-2, the virus that causes COVID-19, elusive to the immune system is that it is covered in sugars called glycans.

25 Feb 2021

Maternal diet may enhance immune systems of premature infants, study shows

Medical researchers have long understood that a pregnant mother's diet has a profound impact on her developing fetus's immune system and that babies -- especially those born prematurely -- who are fed breast milk have a more robust ability to fight disease, suggesting that even after childbirth, a mother's diet matters.

25 Feb 2021

Study reveals molecular details of SARS-CoV-2 interactions with human cells

In order to infect cells, SARS-CoV-2, the virus that causes COVID-19, needs to insert itself into the membrane of human cells. New molecular models show what parts of SARS-CoV-2 are critical for that interaction, revealing new potential drug targets.

25 Feb 2021

Insilico Medicine discovers novel preclinical candidate to address idiopathic pulmonary fibrosis

Insilico Medicine has demonstrated a breakthrough in Artificial Intelligence ("AI") and drug discovery -- linking together generative chemistry and biology for the first time -- to discover a novel preclinical candidate addressing idiopathic pulmonary fibrosis ("IPF") and be validated with multiple human cell and animal model experiments.

25 Feb 2021

Novel single-particle digital assay using plasmonic nanobubbles

An interdisciplinary team from the University of Texas applied DIAMOND to the respiratory syncytial virus (RSV) diagnostics and demonstrated that DIAMOND is 150 times more sensitive than commercial lateral flow assays. They found that the measurements are completed within 2 minutes. The results of this study are published on the medRxiv* preprint server.

25 Feb 2021

Process of molecular sorting emerges from combination of two spontaneous mechanisms, indicates study

The eukaryotic cell is the basic unit of animals and plants. At the microscope, it looks highly structured and subdivided in many membrane-bound compartments.

25 Feb 2021

SARS-CoV-2 does not infect the entire body in the same way, finds study

COVID-19, the disease caused by the pandemic coronavirus SARS-CoV-2, is primarily regarded as a respiratory infection. Yet the virus has also become known for affecting other parts of the body in ways not as well understood, sometimes with longer-term consequences, such as heart arrhythmia, fatigue and "brain fog."

24 Feb 2021