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How a novel reaction in E. coli helps recycle plastic into paracetamol

Researchers have demonstrated that E. coli can perform a biocompatible Lossen rearrangement, enabling phosphate-catalysed conversion of synthetic substrates into valuable compounds. This approach allows engineered bacteria to upcycle PET plastic waste into paracetamol, highlighting a novel intersection of chemistry and biotechnology.

24 Jun 2025

Korean scientists uncover how aging spreads through the blood

For the first time in the world, a Korean research team discovered how cellular aging can spread systemically through the bloodstream-offering new insights and a potential therapeutic strategy to combat aging-related decline.

24 Jun 2025

New technology unlocks cellular ancestry with DNA barcodes

A landmark study by WEHI scientists has shed new light on one of the most fundamental mysteries of biology: how cells divide and grow into the complex structures that make up our bodies.

24 Jun 2025

Scientists warn of rising threat as poultry disease shows signs of jumping to humans

Avian Intestinal Spirochaetosis (AIS) is a chronic, underreported poultry disease caused by Brachyspira spp., with rising concern over its zoonotic risk to humans. This review highlights key challenges in diagnosis, antibiotic resistance, transmission, and the urgent need for improved surveillance and new prevention strategies.

23 Jun 2025

Next generation CAR-T cells push the boundaries of lymphoma treatment

CAR-T cells, which are genetically programmed to specifically recognize and kill target cells, have altered the therapeutic landscape of lymphoma.

23 Jun 2025

Targeted nanoparticles enable in vivo production of CAR T cells for cancer therapy

Researchers present a new method to safely and preferentially generate CAR T cells directly inside the body using targeted lipid nanoparticles that deliver mRNA directly to T cells.

20 Jun 2025

PDE3 inhibitors show promise in promoting bone growth

Bone growth occurs through the proliferation of specialized cells of the cartilage tissue, known as chondrocytes, on either end of a bone.

17 Jun 2025

New nanoparticle platform breaks through MRSA biofilms

A major cause of hospital-acquired infections, the super bacteria Methicillin-resistant Staphylococcus aureus (MRSA), not only exhibits strong resistance to existing antibiotics but also forms a dense biofilm that blocks the effects of external treatments.

14 Jun 2025

New CRISPR tool enables precise chemical modification of RNA in living cells

CRISPR-Cas13, a powerful RNA-targeting technology is gaining increasing attention as a next-generation gene therapy platform due to its precision and reduced side effects.

12 Jun 2025

Green light activates modified penicillin to target bacterial infections

To treat bacterial infections, medical professionals prescribe antibiotics. But not all active medicine gets used up by the body.

12 Jun 2025

Nanoplastics reshape gut microbiome, weakening gut defenses

Polystyrene nanoplastics impact gut health by modifying microbiota interactions via extracellular vesicles, raising concerns about environmental nanoplastics.

12 Jun 2025

New therapeutic approach targets PCSK9 to regulate blood cholesterol levels

When the amount of cholesterol in the blood is too high, hypercholesterolemia can develop, causing serious damage to the arteries and cardiovascular health.

11 Jun 2025

CHAF1B drives lung squamous cell carcinoma progression by repressing SETD7

CHAF1B, a histone chaperone component of the chromatin assembly factor-1 complex, is overexpressed in multiple cancers and linked to tumor progression, but its role in lung squamous-cell carcinoma (LUSC) remained unclear.

11 Jun 2025

Novel self-propelled ferroptosis nanoinducer achieves deeper penetration into tumor tissues

A novel self-propelled ferroptosis nanoinducer developed by Southern Medical University was able to achieve deeper penetration into tumor tissues to show enhanced anti-cancer effects, while remaining considerable biocompatibility.

10 Jun 2025

Centauri Therapeutics publishes proof-of-concept data demonstrating activity of a novel bifunctional immunotherapy against Gram-negative bacterial infections

Centauri Therapeutics Limited (Centauri), an immunotherapy company with a unique and proprietary platform technology applicable across a wide range of therapeutic indications, today announced the publication of a peer-reviewed study in The Journal of Immunology.

10 Jun 2025

CN Bio introduces cross-species DILI services to enhance in vitro to in vivo extrapolation during preclinical drug development

CN Bio, a leading provider of Organ-on-a-chip (OOC) systems and solutions that accelerate drug discovery and development workflows, has introduced two new animal microphysiological system (MPS) models that enhance translatability in preclinical drug safety and toxicology assessments to its Contract Research Services (CRS). Building upon the Company's FDA-recognized drug induced liver injury (DILI) assay, the expanded offering enables rapid, comparative studies between commonly used animal and human models to flag interspecies differences early, and better informs in vivo study design.

10 Jun 2025

Manganese-coordinated lipid nanoparticles boost VZV vaccine-induced T cell responses

Announcing a new article publication for Zoonoses journal. Because varicella zoster virus (VZV) infections are continually increasing, vaccine efficacy must be enhanced.

10 Jun 2025

Glycan mapping reveals what keeps the vaginal microbiome healthy

Glycan-bacteria binding profiles in the vaginal microbiome provide insights into reproductive health, highlighting targets for infection prevention strategies.

9 Jun 2025

Shift Bioscience identifies novel single-gene target for safer cellular rejuvenation therapeutics

Shift Bioscience (Shift), a biotechnology company uncovering the biology of cell rejuvenation to develop new therapies for age driven diseases, today announced the publication of new research identifying a novel, single-gene target for cellular rejuvenation.

9 Jun 2025

Breakthrough soft robotics could redefine artificial heart technology

The Hybrid Heart, a soft robotic total artificial heart, offers a breakthrough in treating end-stage heart failure with improved biocompatibility and function.

5 Jun 2025

in vivo News and Research

How a novel reaction in E. coli helps recycle plastic into paracetamol

Korean scientists uncover how aging spreads through the blood

New technology unlocks cellular ancestry with DNA barcodes

Scientists warn of rising threat as poultry disease shows signs of jumping to humans

Next generation CAR-T cells push the boundaries of lymphoma treatment

Targeted nanoparticles enable in vivo production of CAR T cells for cancer therapy

PDE3 inhibitors show promise in promoting bone growth

New nanoparticle platform breaks through MRSA biofilms

New CRISPR tool enables precise chemical modification of RNA in living cells

Green light activates modified penicillin to target bacterial infections

Nanoplastics reshape gut microbiome, weakening gut defenses

New therapeutic approach targets PCSK9 to regulate blood cholesterol levels

CHAF1B drives lung squamous cell carcinoma progression by repressing SETD7

Novel self-propelled ferroptosis nanoinducer achieves deeper penetration into tumor tissues

Centauri Therapeutics publishes proof-of-concept data demonstrating activity of a novel bifunctional immunotherapy against Gram-negative bacterial infections

CN Bio introduces cross-species DILI services to enhance in vitro to in vivo extrapolation during preclinical drug development

Manganese-coordinated lipid nanoparticles boost VZV vaccine-induced T cell responses

Glycan mapping reveals what keeps the vaginal microbiome healthy

Shift Bioscience identifies novel single-gene target for safer cellular rejuvenation therapeutics

Breakthrough soft robotics could redefine artificial heart technology

eBook: Using iPSCs models for human disease research and drug discovery eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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