Preclinical News and Research

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Non-invasive immune monitoring via bandage-like microneedle patches

Researchers at The Jackson Laboratory (JAX), in collaboration with the Massachusetts Institute of Technology (MIT), have developed the first bandage-like microneedle patch that can sample the body's immune responses painlessly from the skin.

2 Mar 2026

Living in deprived neighborhoods reshapes the gut microbiome

This study reveals links between socioeconomic deprivation and gut microbiome changes, highlighting potential pathways to mental and metabolic health issues.

2 Mar 2026

How zinc deficiency could worsen heart inflammation and what that means for patients

This review examines how zinc regulates inflammatory and redox signaling pathways involved in myocarditis and pericarditis, highlighting mechanisms such as NF-κB inhibition and the redox zinc switch. The authors conclude that maintaining optimal zinc status may support cardiovascular resilience, while emphasizing that clinical translation requires further targeted trials.

1 Mar 2026

New review explains how circular RNAs could unlock fat browning therapies

A Cell Death & Disease review synthesizes preclinical evidence that circular RNAs regulate adipose browning and metabolic pathways through microRNA interactions, protein binding, and organelle-linked stress mechanisms. It highlights their biomarker and therapeutic potential in obesity and type 2 diabetes while underscoring key translational challenges, including delivery specificity and human validation.

26 Feb 2026

Researchers reveal why SuperAgers retain youthful brain cell signatures into their 80s

Researchers used single-nucleus RNA sequencing and chromatin accessibility profiling to map human hippocampal neurogenesis across adulthood, aging, and Alzheimer’s disease. They found that chromatin accessibility changes, more than gene expression alone, distinguish healthy aging, preclinical pathology, Alzheimer’s disease, and cognitive resilience in SuperAgers.

26 Feb 2026

Ultra-sensitive CAR T cells target solid tumors

Though CAR T cells have been effective against certain blood cancers, they have not been for solid tumors.

26 Feb 2026

Road traffic noise linked to immediate heart and blood vessel stress

A new study published in the journal Cardiovascular Research shows that a single night of road traffic noise, at levels that are typical of those living in a city, causes stress to the heart and blood vessels.

25 Feb 2026

Superagers show greater neuron growth linked to strong memory

Brains of older adults with super healthy cognition grow more new neurons than those of their peers, according to a study from UIC, Northwestern University and the University of Washington.

25 Feb 2026

Barshop Institute at UT Health San Antonio secures major federal funding for longevity trial

Positioning The University of Texas at San Antonio as a national anchor for aging and longevity science, its Sam and Ann Barshop Institute for Longevity and Aging Studies will receive up to $38 million in federal funding for the first nationwide clinical study in healthy longevity.

24 Feb 2026

Automated platform finds unexpected enhancers for mRNA therapeutics

Integrating AI with advanced robotics to create self-driving labs (SDL) is a promising approach to tackling molecular discovery.

24 Feb 2026

Combined GLP-1 and GLP-2 treatment appears safe but does not beat placebo for obesity

In a 12-week randomized phase IIa trial in adults with obesity, the dual GLP-1/GLP-2 receptor agonist dapiglutide was well tolerated but did not achieve statistically significant weight loss compared with placebo at 4 mg or 6 mg doses. Although the higher dose showed modest within-group weight reduction and improved HbA1c, unexpectedly substantial placebo-associated weight loss limited the observed treatment effect.

24 Feb 2026

Centauri Therapeutics extends Series A to £30 M with £6 M investment from AMR Action Fund to support progression of lead clinical candidate

Centauri Therapeutics Limited ('Centauri'), an immunotherapy company with a unique and proprietary platform technology applicable across a wide range of therapeutic indications, today announced it has secured £6 M from AMR Action Fund, extending the Company's Series A round to £30 M.

24 Feb 2026

Early exposure to unhealthy foods leaves lasting brain and feeding changes

Eating unhealthy foods early in life leave lasting brain and feeding changes but gut bacteria can help restore healthy eating, new University College Cork (UCC) research study finds today (Tuesday 24th February 10am)

24 Feb 2026

Transforming obese fat cells into energy burners

Ordinary fat cells in obese animals can be induced to burn energy stores, generating substantial heat, according to a preclinical study by Weill Cornell Medicine investigators.

23 Feb 2026

Rytvela lowers inflammation and improves newborn survival in preclinical study

New research shows that Rytvela, an anti-inflammatory drug candidate, decreased premature birth and infant mortality when administered after the onset of preterm labor in a preclinical mouse model.

23 Feb 2026

Study captures real-time protein clumping linked to Alzheimer’s

An Oregon State University scientist and a team of undergraduate students have uncovered real-time insights into a chemical process linked with Alzheimer's disease, paving the way toward better drug designs.

23 Feb 2026

Engineers develop highly precise gene editor for safer cystic fibrosis treatments

Engineers at the University of Pennsylvania and Rice University have refined a technology for editing individual genetic "base pairs" to a new level of precision, opening the door to safer, more reliable therapies for a wide range of genetic diseases, and to potential treatments for some cystic fibrosis patients that may yield better outcomes than existing therapies.

23 Feb 2026

New review explores whether berries can slow cognitive decline linked to obesity

This systematic review in Nutrients evaluates human studies investigating whether polyphenol-rich berry consumption can modulate obesity-related metabolic dysfunction and support cognitive performance, particularly in individuals at risk of mild cognitive impairment. Evidence suggests modest memory benefits and possible metabolic improvements, although biomarker findings and long-term clinical relevance remain uncertain.

22 Feb 2026

Study identifies PPP2R5C blood marker that may detect Alzheimer’s disease earlier

Emerging evidence suggests reduced plasma PPP2R5C levels may serve as an early indicator of Alzheimer’s disease before overt clinical symptoms appear. The protein appears linked to tau regulation, autophagy pathways, and cognitive decline, supporting its potential diagnostic relevance.

22 Feb 2026

Blood test models predict when Alzheimer’s symptoms may start years in advance

Researchers developed plasma p-tau217–based clock models that estimate when cognitively unimpaired individuals with Alzheimer’s pathology may develop symptomatic disease. The models predicted symptom onset within about three to four years and may help improve clinical trial selection while remaining unsuitable for individual clinical decisions at present.

22 Feb 2026

Preclinical News and Research

Non-invasive immune monitoring via bandage-like microneedle patches

Living in deprived neighborhoods reshapes the gut microbiome

How zinc deficiency could worsen heart inflammation and what that means for patients

New review explains how circular RNAs could unlock fat browning therapies

Researchers reveal why SuperAgers retain youthful brain cell signatures into their 80s

Ultra-sensitive CAR T cells target solid tumors

Road traffic noise linked to immediate heart and blood vessel stress

Superagers show greater neuron growth linked to strong memory

Barshop Institute at UT Health San Antonio secures major federal funding for longevity trial

Automated platform finds unexpected enhancers for mRNA therapeutics

Combined GLP-1 and GLP-2 treatment appears safe but does not beat placebo for obesity

Centauri Therapeutics extends Series A to £30 M with £6 M investment from AMR Action Fund to support progression of lead clinical candidate

Early exposure to unhealthy foods leaves lasting brain and feeding changes

Transforming obese fat cells into energy burners

Rytvela lowers inflammation and improves newborn survival in preclinical study

Study captures real-time protein clumping linked to Alzheimer’s

Engineers develop highly precise gene editor for safer cystic fibrosis treatments

New review explores whether berries can slow cognitive decline linked to obesity

Study identifies PPP2R5C blood marker that may detect Alzheimer’s disease earlier

Blood test models predict when Alzheimer’s symptoms may start years in advance

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