Caffeine News and Research

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Caffeine is a bitter substance found in coffee, tea, soft drinks, chocolate, some nuts and certain medicines. It has many effects on the body's metabolism, including stimulating the central nervous system. This can make you more alert and give you a boost of energy.

OYE Therapeutics doses first subject in bridging study of intravenous caffeine formulation

OYE Therapeutics Inc., a clinical-stage biotechnology company developing therapies for perioperative and emergency medicine, announced that the first subject has been dosed in its scientific bridging study evaluating OYE-101.

7 Apr 2026

Moderate coffee intake may lower heart failure risk

A systematic review and dose-response meta-analysis of seven prospective cohorts found that drinking 2 to 4 cups of coffee a day was associated with a modestly lower risk of incident heart failure. The lowest estimated risk appeared at 1 to 2 cups daily, although the evidence for a true non-linear J-shaped pattern was suggestive rather than definitive.

24 Mar 2026

Scientists reveal how light-activated drugs change receptor activity

Rendering a drug effective or ineffective in a flash at the appropriate location – this is the focus of research in photopharmacology.

19 Mar 2026

Does coffee disrupt sleep? Large population study suggests the impact may be minimal

A large cross-sectional analysis of 25,381 Swedish adults aged 50–64 found that habitual coffee consumption showed only very weak associations with sleep quality and daytime sleepiness. Genetic analyses confirmed known coffee-related variants and suggested that long-term caffeine exposure may lead to adaptation in the brain’s adenosine signaling system.

11 Mar 2026

Tracking physiological stress during prolonged virtual soccer

Extended esports play can lead to mental fatigue, resulting in slower and less precise decision-making (diminished executive control) and a variety of physiological responses indicative of impaired sensorimotor or cognitive function.

5 Mar 2026

Experts share essential tips for maintaining healthy sleep during daylight saving time

The month of March brings the promise of warmer weather and longer days ahead. But adjusting to the change in clocks can be tricky. Here's how you can maintain good sleeping habits when the clock jumps forward on March 8.

4 Mar 2026

Drinking sparkling water helps gamers stay mentally sharp for hours

Sparkling water may combat cognitive fatigue in gamers, sustaining mental sharpness and executive function during extended esports sessions without stimulants.

4 Mar 2026

Experts identify safest and most effective diets for IBS management

This review in Nutrients evaluates the scientific evidence, clinical effectiveness, and safety of major dietary strategies for irritable bowel syndrome, including traditional advice, low-FODMAP, gluten-free, Mediterranean, and starch- and sucrose-reduced diets. It concludes that while the low-FODMAP diet has the strongest short-term evidence, no single approach fits all patients, and dietitian-led personalization is essential.

2 Mar 2026

Greater food variety at buffets may lead to overeating

At Super Bowl parties, weddings, Independence Day cookouts and Thanksgiving dinners, people celebrate with large spreads of food.

27 Feb 2026

Misdiagnosed Parkinson's patient regains life after NPH treatment

At age 66, Richard "Dick" Nash first suspected something might be wrong when he participated in a Dallas walk for juvenile diabetes in honor of his granddaughter.

26 Feb 2026

Road traffic noise linked to immediate heart and blood vessel stress

A new study published in the journal Cardiovascular Research shows that a single night of road traffic noise, at levels that are typical of those living in a city, causes stress to the heart and blood vessels.

25 Feb 2026

Study reveals coffee triggers distinct cytokine responses compared with pure caffeine

A randomized crossover pilot study in healthy adults found that coffee and isolated caffeine produce distinct short-term immune responses despite equivalent caffeine doses. The results suggest non-caffeine coffee compounds may influence cytokine activity and caffeine metabolism, although findings remain preliminary due to the small sample size.

19 Feb 2026

Do cocoa flavanols influence heart and fatty liver risk factors?

A recent Nutrients review examined whether cocoa-rich dark chocolate influences cardiovascular and metabolic dysfunction-associated steatotic liver disease risk factors through antioxidant, anti-inflammatory, and endothelial effects. Evidence suggests modest improvements in biomarkers, but most data come from short-term studies, so definitive clinical benefits remain unproven.

16 Feb 2026

Review links betel nut addiction to cancer, heart disease, and metabolic risks

This review examines the epidemiology, health risks, neurobiological mechanisms, and emerging treatments related to betel nut addiction worldwide. It highlights strong links with oral cancer, cardiometabolic disease, and addiction pathways while noting limited established therapies and the need for coordinated public health strategies.

11 Feb 2026