Exhaustion News and Research

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Academic burnout pushes Chinese adolescents toward excessive online gaming habits

Chinese researchers report that academic burnout can push adolescents towards excessive online gaming. Using a large-scale cross-sectional survey, the researchers assessed the associations among academic burnout, internet gaming, depressive symptoms, and attentional bias.

29 Apr 2026

Cancer during pregnancy causes lasting emotional and financial challenges

Women diagnosed with cancer in pregnancy face profound, long-term emotional and financial challenges, a new study from the University of Surrey finds.

22 Apr 2026

McMaster researchers identify new DNA region linked to frailty

Researchers at McMaster University have identified, for the first time, a novel region of DNA and two associated genes connected to frailty, offering neurological and immune-related insights that might help explain why some older adults are more likely to be frail than others.

22 Apr 2026

Trial shows safety of novel KIR-CAR T therapy in solid tumors

An innovative type of CAR T cell therapy, called KIR-CAR, was shown to be safe, with increasing efficacy corresponding to higher doses of the investigational treatment in nine patients with advanced ovarian cancer, mesothelioma or cholangiocarcinoma (bile duct cancer), according to an early report from an ongoing Phase I dose-escalation clinical trial.

20 Apr 2026

Single CAR T infusion shows strong response in smoldering multiple myeloma patients

A single infusion of ciltacabtagene autoleucel (Carvykti) led to a 100% minimal residual disease (MRD)-negativity rate in patients with high-risk smoldering multiple myeloma, according to results from CAR-PRISM, a phase II clinical trial, presented at the American Association for Cancer Research (AACR) Annual Meeting 2026, held April 17-22.

20 Apr 2026

Academic stress weakens mental resilience and triggers a reliance on gaming

China's highly competitive education system is known for its strict evaluation, rigorous intensity, and academic pressure. A recent study has highlighted the growing problem of this academic pressure leading to burnout amongst Chinese adolescents, which is pushing them towards online gaming.

17 Apr 2026

Clusterin inhibition offers new hope for treating cervical gastric-type adenocarcinoma

Gastric-type adenocarcinoma (GAS) is one of the most aggressive non-human papillomavirus (HPV)-associated cervical adenocarcinomas and remains especially difficult to diagnose and treat.

8 Apr 2026

Longer working hours associated with higher risk of nonrestorative sleep and poor mental health

Mental load, invisible work, "the extra shift"; no matter the newly coined term, unpaid work in the domestic sphere, predominantly done by women, is a hidden burden eating away at the sleep and mental health of those tasked with it.

7 Apr 2026

How the nutrient cysteine controls cancer-fighting power of T cells

A research team from the Johns Hopkins Kimmel Cancer Center, its Bloomberg~Kimmel Institute for Cancer Immunotherapy and the Johns Hopkins Bloomberg School of Public Health have discovered how the immune system's CD8+ T cells use the nutrient cysteine to control two essential functions that compete for this resource - the immune cell's ability to multiply and its ability to kill cancer cells.

31 Mar 2026

New study links physician burnout to higher rates of medical staff turnover

Family physicians who report feeling burned out are nearly 1.5 times more likely to change practices or stop practicing medicine entirely compared to their peers who don't report burnout, a study by Weill Cornell Medicine researchers found.

30 Mar 2026

New approach helps immune cells find and attack solid tumors

A technique that transforms immune cells into cancer-seeking bloodhounds may overcome a roadblock that has hampered immunotherapy for solid tumors, according to a new study by Stanford Medicine researchers.

24 Mar 2026

Mitochondrial-proteasome-heme axis rewires T cell fate and weakens cancer therapy

Cancer-fighting T cells do not simply "run out of energy." They are molecularly reprogrammed.

18 Mar 2026

Burnout crisis demands science-based strategies beyond self-care solutions

Burnout is at an all-time high, with some studies saying two-thirds of employees now cite job burnout as a major challenge.

18 Mar 2026

New nanoparticle therapy overcomes T cell exhaustion in solid tumors

Engineers at the University of Pennsylvania have developed a new type of lipid nanoparticle (LNP) that could one day serve as a universal immunotherapy for cancers that form solid tumors, including common variants such as cancers of the breast, liver and colon.

18 Mar 2026

Swedish study reveals COVID-19 may increase glandular fever risk

Even individuals who did not become seriously ill with COVID-19 may have developed a weakened immune system that could lead to serious illnesses in the future.

17 Mar 2026

Scientists identify common symptom patterns in post-COVID-19 vaccination syndrome

A registry study across 14 Japanese clinics analyzed 179 cases of post-COVID-19 vaccination syndrome (PCVS) and identified 493 adverse events affecting multiple organ systems. Most symptoms appeared within 90 days, but some occurred much later, highlighting the need for continued vaccine safety monitoring and better clinical frameworks for persistent post-vaccination symptoms.

16 Mar 2026