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Scientists unravel how citrin deficiency can trigger fat buildup in the liver even in lean individuals

Scientists at City of Hope, one of the largest and most advanced cancer research and treatment organizations in the U.S. and a leading research center for diabetes and other life-threatening illnesses, have unraveled how citrin deficiency (CD), a rare genetic disorder that prevents the liver from converting food into energy efficiently, can trigger fat buildup in the liver - even in lean individuals.

18 Dec 2025

Social living allows genetic effects to spread through the gut microbiome

Your "roommate's" genes could be influencing the bacteria living in your gut, and vice versa, according to a study of rats published today in Nature Communications.

18 Dec 2025

Mucus-inspired hydrogel resists stomach acid and promotes gastrointestinal healing

The Hong Kong Polytechnic University (PolyU) has developed an acid-resistant "ultra-stable mucus-inspired hydrogel" (UMIH), marking a breakthrough in the field of gastrointestinal medicine.

17 Dec 2025

Multicolor fluorescent tagging enables real-time visualization of RNA in living cells

An innovative three-color method for capturing images of mRNA inside live mammalian cells has been developed by UMass Amherst chemists.

17 Dec 2025

Specific gut bacterium reduces weight gain and improves metabolic health

The gut microbiome is intimately linked to human health and weight. Differences in the gut microbiome-the bacteria and fungi in the gut-are associated with obesity and weight gain, raising the possibility that changing the microbiome could improve health.

16 Dec 2025

New diagnostic chip enables rapid monitoring of brain cancer treatment

New diagnostic chip pulls packets released from tumor cells out of blood, showing whether cancer cells died during chemotherapy infusion.

16 Dec 2025

Revolutionary quantum sensors could enable earlier cancer diagnosis and treatment

A revolutionary quantum sensing project that could transform cancer treatment by tracking how immune cells interact with tumors has been awarded a prestigious £2 million Future Leaders Fellowship.

16 Dec 2025

Novel cryo-EM findings could revolutionize T cell immunotherapy design

One of the most exciting advances in cancer treatments in the past decade is the development of T cell immunotherapies, in which a patient's own immune system is trained to recognize and attack dangerous cells. Yet a full understanding of how they actually work has eluded researchers.

16 Dec 2025

Tau biology expands beyond microtubules to neurodegeneration, metabolism and mental illness

An Thought Leaders Invited Review published today in Genomic Psychiatry by Dr. Peng Lei and colleagues presents a sweeping synthesis of tau protein research that fundamentally reframes our understanding of this molecule's dual identity.

16 Dec 2025

New insights explain the Treg paradox in colorectal cancer

In most solid tumors, high numbers of regulatory T (Treg) cells are associated with poorer outcomes because they dampen the immune system's ability to fight against a tumor.

15 Dec 2025

Scientists create light-controlled versions of cholesterol

High levels of cholesterol are linked to heart disease, stroke, and many other health problems. However, this complex and vital fatty, water insoluble molecule-a lipid-is found in every cell of the body and is not all bad news. It also regulates crucial processes that science has yet to map.

15 Dec 2025

How brain cells manage long distance genetic instructions

Scientists found that messenger RNA (mRNA) molecules that carry genetic instructions to the far reaches of neurons in the brain tend to cluster together mostly because they are abundant, not because they move in coordinated groups.

15 Dec 2025

Novel AI tool not only identifies genetic mutations but also predicts the type of disease

Scientists at the Icahn School of Medicine at Mount Sinai have developed a novel artificial intelligence tool that not only identifies disease-causing genetic mutations but also predicts the type of disease those mutations may trigger.

15 Dec 2025

Bioluminescent tool illuminates single-cell activity in living brains

A decade ago, a group of scientists had the literally brilliant idea to use bioluminescent light to visualize brain activity.

12 Dec 2025

Glycation stress drives aortic stiffening through oxidative stress and senescence

A new research paper was published in Volume 17, Issue 11 of Aging-US on November 14, 2025, titled "Methylglyoxal-induced glycation stress promotes aortic stiffening: putative mechanistic roles of oxidative stress and cellular senescence."

12 Dec 2025

Exclusive licensing agreement accelerates PHD inhibitor development for anemia in CKD patients

Insilico Medicine ("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, and TaiGen Biotechnology, a listed discovery-based and market-focused pharmaceutical company, as well as TaiGen Biopharmaceuticals, its wholly-owned Beijing subsidiary (both referred to as "TaiGen"), today announced an exclusive pipeline out-licensing collaboration.

12 Dec 2025

AI-guided discovery of selective DGKα inhibitors to overcome checkpoint resistance in solid cancers

Insilico Medicine has developed a new class of small molecule inhibitors targeting diacylglycerol kinase alpha (DGKα) designed to restore T cell function and overcome resistance to immune checkpoint blockades in solid cancers.

12 Dec 2025

New findings show why the human intestine uniquely presents gluten to T cells

Human intestinal M cells function as dendritic cell-like antigen-presenting cells, displaying constitutive MHC-II activity and specialized machinery for processing gluten. Their ability to deamidate and present gliadin peptides positions them as key initiators of immune responses relevant to coeliac disease.

11 Dec 2025

Researchers identify enzyme linked to myelin damage and neurodegenerative conditions

Researchers at Oregon Health & Science University have identified a type of enzyme with a complicated name - cell migration inducing and hyaluronan-binding protein, or CEMIP - is associated with disorders ranging from multiple sclerosis to stroke to neurodegenerative conditions like Alzheimer's disease.

11 Dec 2025

Blocking collagen signaling improves the delivery of macromolecular drugs in pancreatic cancer

Pancreatic cancer is one of the deadliest malignancies, with survival rates remaining dismally low despite major advances in oncology.

11 Dec 2025

Molecule News and Research

Scientists unravel how citrin deficiency can trigger fat buildup in the liver even in lean individuals

Social living allows genetic effects to spread through the gut microbiome

Mucus-inspired hydrogel resists stomach acid and promotes gastrointestinal healing

Multicolor fluorescent tagging enables real-time visualization of RNA in living cells

Specific gut bacterium reduces weight gain and improves metabolic health

New diagnostic chip enables rapid monitoring of brain cancer treatment

Revolutionary quantum sensors could enable earlier cancer diagnosis and treatment

Novel cryo-EM findings could revolutionize T cell immunotherapy design

Tau biology expands beyond microtubules to neurodegeneration, metabolism and mental illness

New insights explain the Treg paradox in colorectal cancer

Scientists create light-controlled versions of cholesterol

How brain cells manage long distance genetic instructions

Novel AI tool not only identifies genetic mutations but also predicts the type of disease

Bioluminescent tool illuminates single-cell activity in living brains

Glycation stress drives aortic stiffening through oxidative stress and senescence

Exclusive licensing agreement accelerates PHD inhibitor development for anemia in CKD patients

AI-guided discovery of selective DGKα inhibitors to overcome checkpoint resistance in solid cancers

New findings show why the human intestine uniquely presents gluten to T cells

Researchers identify enzyme linked to myelin damage and neurodegenerative conditions

Blocking collagen signaling improves the delivery of macromolecular drugs in pancreatic cancer

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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