Drug Discovery News and Research

RSS

The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

From crude lysate to purity with high-precision AAV capsid measurement with Bio-Rad's new ddPCR Kit

Accurately quantify AAV capsids directly from crude lysates with Bio-Rad's new ddPCR kit—offering reliable, efficient, and precise measurement to streamline your research workflows.

From Bio-Rad Laboratories 19 Nov 2024

Small Solutions for Big Problems in Drug Discovery and Delivery

Ijeoma Uchegbu discusses nanomedicine's role in improving medication adherence and developing non-addictive pain relief solutions at ELRIG Drug Discovery 2024.

19 Nov 2024

Largest ALS patient-based iPSC repository opens new frontiers in research

In a landmark continuing collaboration, Answer ALS and Cedars-Sinai have announced the completed availability of the largest amyotrophic lateral sclerosis (ALS) patient-based induced pluripotent stem cell (iPSC) and bio data repository.

15 Nov 2024

Argonne receives $21.7 million to advance cancer and vaccine discoveries

The U.S. Department of Energy's (DOE) Argonne National Laboratory will use its world-leading capabilities in artificial intelligence (AI) and high performance computing to research novel ways to fight cancer and transform vaccine discovery.

15 Nov 2024

CN Bio launches PhysioMimix Bioavailability assay kit: Human 18

CN Bio, a leading provider of Organ-on-a-chip Systems and solutions that accelerate drug discovery and development workflows, today announced the launch of its PhysioMimix® Bioavailability assay kit: Human 18. Harnessing the capabilities of the PhysioMimix Multi-organ System, the kit enhances lead optimization and preclinical testing pipelines, providing an all-in-one solution to generate predictive insights into human oral bioavailability, and better inform lead candidate selection.

14 Nov 2024

Self-reported symptom screening reduces symptom burden in pediatric cancer patients

Regular, self-reported symptom screening was associated with reduced symptom burden when compared with usual care for pediatric patients with cancer, according to new research led by scientists at the University of Toronto and The Hospital for Sick Children (SickKids).

14 Nov 2024

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Professor Nancy Ip discusses her groundbreaking neuroscience research, focusing on neurotrophic factors and innovative Alzheimer's disease treatment approaches.

13 Nov 2024

MassiveFold advances protein structure prediction with efficient parallel processing

Researchers developed MassiveFold, an enhanced AlphaFold version optimized for parallel processing, which accelerates protein structure predictions from months to hours while increasing structural diversity.

12 Nov 2024

Nomic® and Parker Institute for Cancer Immunotherapy (PICI) launch large-scale protein profiling to investigate immunotherapy responses in RADIOHEAD study

Nomic Bio and PICI collaborate to quantify protein biomarkers in cancer immunotherapy, enhancing understanding of patient responses and treatment resistance.

From Nomic 12 Nov 2024

Cannabinol enhances sleep in rats, study shows

Research by scientists at the University of Sydney has identified a constituent in the cannabis plant that improves sleep.

11 Nov 2024

Targeted degradation of Pin1 shows promise for pancreatic cancer treatment

In drug discovery, targeted protein degradation is a method that selectively eliminates disease-causing proteins.

11 Nov 2024

AI-READI consortium launches groundbreaking diabetes data study

Researchers today (Nov. 8, 2024) are releasing the flagship dataset from an ambitious study of biomarkers and environmental factors that might influence the development of type 2 diabetes.

8 Nov 2024

Lupus Research Alliance announces 33 studies to be presented at ACR Convergence 2024

The Lupus Research Alliance (LRA), the largest private funder of lupus research worldwide, today announced that a total of 33 studies, funded by the organization or supported by its clinical research affiliate Lupus Therapeutics, will be presented at ACR Convergence 2024.

5 Nov 2024

New AI model BiomedGPT set to transform medical and research practices

A picture may be worth a thousand words, but still…they both have a lot of work to do to catch up to BiomedGPT.

4 Nov 2024

Carbonic anhydrase inhibitors clear tau build-up in zebrafish models of tauopathies

A drug commonly used to treat glaucoma has been shown in zebrafish and mice to protect against the build-up in the brain of the protein tau, which causes various forms of dementia and is implicated in Alzheimer’s disease.

4 Nov 2024

Study identifies cellular and molecular roots of individual brain connectivity differences

Researchers link microscopic protein structures and cellular interactions to individual differences in brain connectivity, offering new insights into brain function and variability.

3 Nov 2024

Glaucoma medication may help prevent Alzheimer's-related tau build-up

1 Nov 2024

Sapio Sciences Expands Collaboration With AWS to Advance Science-Aware™ AI Vision

...

From Sapio Sciences 1 Nov 2024

New technology streamlines drug discovery using single-molecule tracking

New drug discovery is a critical step for improving patients' lives. First, researchers must identify molecules in the body's cells that help drive disease, as these are potential targets for new drugs. The next step is to screen candidate drugs that can hit those targets.

1 Nov 2024

New pipeline analyzes drug responses in primary tumors

In a major leap toward more effective cancer treatments, researchers at the University of Oulu have developed an innovative pipeline designed to directly analyze drug responses in primary patient tumor samples.

1 Nov 2024