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A macrophage is a type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells.

Study reveals the effects of cannabis use on oral microbiome and brain health

More and more states are legalizing marijuana, but little is known about how long-term cannabis use affects the microbes in the oral cavity, known as the oral microbiome.

6 Dec 2021

Novel monoclonal antibody could help revolutionize treatment of children with high-risk neuroblastoma

Survival rates increased about 20% for children with high-risk neuroblastoma enrolled in a St. Jude Children’s Research Hospital clinical trial that included a novel monoclonal antibody produced onsite. The findings appeared today in the Journal of Clinical Oncology.

6 Dec 2021

New approach to COVID-19 immune profiling using blood-based machine learning

A new study discusses the application of a novel deconvolution model AImmune to predict moderate and severe cases of COVID-19.

5 Dec 2021

Mtb's exotoxin secretion and trafficking mechanism revealed

Six years ago, Michael Niederweis, Ph.D., described the first known toxin of the deadly pathogen Mycobacterium tuberculosis (Mtb), an exotoxin that had gone undetected for 132 years.

25 Nov 2021

Maternal-fetal interface yields intriguing clues to how it battles SARS-CoV-2

Scientists have hypothesized that the number of immune cells and the amount of cytokines produced in response to SARS-CoV-2 infection in pregnant women change in accordance with the timing of maternal infection in pregnancy. This study is available on the bioRxiv* preprint server.

24 Nov 2021

Study shows SARS-CoV-2 can infect and replicate in human iPSC-derived neurons

In a study recently published on the bioRxiv preprint server, researchers attempted to further increase the scope of previous studies in examining SARS-CoV-2 infection of human CNS resident cells.

22 Nov 2021

Young adults with cancer may require different treatments than older patients

Not all tumors are alike. Young adults who are diagnosed with skin, colon, and other cancer types may require different treatments than older patients receive.

16 Nov 2021

New therapy targets rodents' cells rather than bacterial cells in treating pneumonia

Researchers at the National Institutes of Health have discovered a therapy that targets host cells rather than bacterial cells in treating bacterial pneumonia in rodents.

15 Nov 2021

Study may pave the way for a more personalized approach to COVID-19 diagnosis and treatment

Using some of the most advanced molecular sequencing tools available to evaluate COVID-19 rapid autopsy tissues, researchers have identified four major regulatory pathways, specific molecular effectors behind COVID-19 symptoms, and differences that drive diverging clinical courses among individual patients.

11 Nov 2021

Current understanding of the link between COVID-19 and cardiovascular disease

A review published in Chemo-Biological Interactions has focused on the prevalence of COVID-19 in CVD patients associated with ACE2 mechanisms.

10 Nov 2021

SARS-CoV-2 leaves long-term impact on olfactory neurocircuit

The current study looked at the impact of the virus on the CNS in the Syrian golden hamster, a useful animal model for COVID-19.

9 Nov 2021

Investigation of Budesonide's mechanism of action against SARS-CoV-2

Researchers look to gain an understanding of the mechanism of action of budesonide in improving the prognosis of patients with SARS-CoV-2 infection.

1 Nov 2021

Alteration in gut microbiome may lead to hyperinflammation in severe COVID-19

A team of international scientists has recently identified a distinct set of proinflammatory mediators and metabolites associated with the fatal consequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Moreover, they have established a link between gut microbiome alteration and hyper-inflammatory response in patients with severe COVID-19. The study is currently available on the bioRxiv* preprint server.

1 Nov 2021

Study identifies how cancer cells transform macrophages into supporters of their growth

A Ludwig Cancer Research study has identified a means by which cancer cells engineer the conversion of immune cells known as macrophages from destroyers of tumors to supporters of their growth and survival.

26 Oct 2021

Sexually dimorphic placental antibody transfer during SARS-CoV-2 infection

In a paper recently published in the journal Science Translational Medicine by Bordt et al. (October 19th, 2021), maternal SARS-CoV-2 infections are studied with particular regard to maternal-fetal antibody transfer and virus-induced placental interferon responses, finding a sexually dimorphic response that results in lesser antibody transfer to the male fetus.

26 Oct 2021

Discovery could lead to new treatments for axial spondyloarthritis

In a paper published today in the journal Science Translational Medicine, researchers at the Schroeder Arthritis Institute, part of University Health Network in Toronto, have made a discovery that could lead to new treatments for axial spondyloarthritis (SpA), a painful and debilitating form of arthritis which affects 1-2% of Canadians and causes inflammation in the spine, joints, eyes, gut and skin.

20 Oct 2021