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Aficamten outperforms beta-blockers in treating patients with obstructive hypertrophic cardiomyopathy

Aficamten treatment was associated with significant improvements in exercise capacity and symptoms compared with metoprolol in patients with symptomatic obstructive hypertrophic cardiomyopathy (HCM), according to late-breaking research presented in a Hot Line session today at ESC Congress 2025 and simultaneously published in New England Journal of Medicine.

1 Sep 2025

Research finds no added benefit from routine CT imaging after left main coronary intervention

Routine coronary computed tomography (CCT)-based follow-up after percutaneous coronary intervention (PCI) of the left main coronary artery did not reduce death, myocardial infarction (MI), unstable angina or stent thrombosis compared with symptom-based follow-up, according to late-breaking research presented in a Hot Line session today at ESC Congress 2025.

1 Sep 2025

Triglyceride levels substantially reduced with olezarsen compared to placebo

Olezarsen decreased levels of triglycerides compared with placebo in patients with moderate hypertriglyceridemia and elevated cardiovascular risk, according to a late-breaking trial presented in a Hot Line session today at ESC Congress 2025 and simultaneously published in New England Journal of Medicine.

1 Sep 2025

Phase II trial finds zilebesiran lowers systolic blood pressure in patients with uncontrolled hypertension

Among individuals with cardiovascular disease or high cardiovascular risk and uncontrolled hypertension on multiple anti-hypertensive agents, a single subcutaneous dose of zilebesiran 300 mg led to a 5-mmHg reduction in systolic blood pressure at Month 3 compared with placebo, a difference that did not reach statistical significance.

1 Sep 2025

Extended apixaban therapy lowers recurrent VTE in patients with provoked events and enduring risk factors

Apixaban 2.5 mg twice daily significantly reduced symptomatic venous thromboembolism (VTE) recurrence, with a low risk of major bleeding, in patients with provoked VTE and enduring risk factors, according to late-breaking research presented in a Hot Line session today at ESC Congress 2025 and simultaneously published in New England Journal of Medicine.

1 Sep 2025

AMALFI trial finds small increase in AF diagnosis with mail-based ECG patch monitoring

A mail-based atrial fibrillation (AF) screening programme with ECG-patch monitoring led to a modest long-term increase in AF diagnosis and anticoagulation exposure in older patients at moderate-to-high stroke risk, according to a late-breaking trial presented in a Hot Line session today at ESC Congress 2025 and simultaneously published in JAMA (The Journal of the American Medical Association).

1 Sep 2025

$Beta blockers reduce mortality and heart failure in MI patients with mildly reduced ejection fraction$

Beta blockers reduce mortality and heart failure in MI patients with mildly reduced ejection fraction

Beta-blocker therapy significantly reduced a composite endpoint of all-cause mortality, new myocardial infarction (MI) and heart failure (HF) compared with no beta-blocker therapy in the subgroup of patients with MI and mildly reduced left ventricular ejection fraction (LVEF), according to an individual patient data meta-analysis presented in a Hot Line session today at ESC Congress 2025.

1 Sep 2025

Evidence-based calculator to guide hypertension treatment choices

A first-of-its-kind Blood Pressure Treatment Efficacy Calculator built on data from nearly 500 randomized clinical trials in over 100,000 people allows doctors to see by how much different medications are likely to lower blood pressure.

28 Aug 2025

Most Americans unaware that early prostate cancer shows no symptoms

A recent survey commissioned by The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) focused on Americans' awareness of the signs and symptoms of prostate cancer.

28 Aug 2025

Native Hawaiian and Pacific Islander people face highest stroke rates in the U.S.

A new study found that Native Hawaiian or Pacific Islander people had the highest rate of stroke among people from other race and ethnic groups, with a rate more than three times higher than that of white people.

28 Aug 2025

Hormone therapy type may influence postmenopausal cognitive health

The type of estradiol-based hormone therapy taken during and after menopause, such as patches or pills, may be associated with differences in memory performance, according to a study published on August 27, 2025, in Neurology, the medical journal of the American Academy of Neurology.

28 Aug 2025

Can the gut microbiome adapt to protect the brain after stroke?

Alterations in gut microbiota post-stroke may drive metabolic changes, presenting opportunities for innovative therapeutic strategies in acute stroke recovery.

28 Aug 2025

Most US neurologists prescribing multiple sclerosis drugs receive pharma industry payments

Nearly 80% of US neurologists prescribing drugs for multiple sclerosis (MS) received at least one pharma industry payment, with higher volume prescribers more likely to be beneficiaries, finds a 5 year analysis of Medicare database payments, published in the open access journal BMJ Open.

27 Aug 2025

An insurer agreed to cover her surgery. A politician’s nudge got the bills paid.

For the most part, Keyanna Jones and her husband thought they knew what to expect when their daughter Chloë had eye surgery last fall.

26 Aug 2025

Small peptide produced by gut bacteria identified as key factor in kidney fibrosis

A molecule made by bacteria in the gut can hitch a ride to the kidneys, where it sets off a chain reaction of inflammation, scarring and fibrosis - a serious complication of diabetes and a leading cause of kidney failure - according to a new study from researchers at the University of Illinois Urbana-Champaign and Mie University in Japan.

25 Aug 2025

Many people unaware that knee and groin pain could signal hip problems

Having a hard time bending over to put your shoes on? Experiencing pain in the knees, groin, thigh or back? A new survey by The Ohio State University Wexner Medical Center reveals many people don't realize these symptoms can mean there's a problem in the hip.

25 Aug 2025

As measles exploded, officials in Texas looked to CDC scientists. Under Trump, no one answered.

As measles surged in Texas early this year, the Trump administration's actions sowed fear and confusion among CDC scientists that kept them from performing the agency's most critical function — emergency response — when it mattered most, an investigation from KFF Health News shows.

25 Aug 2025

Gut bacteria in mothers and newborns may shape infants’ risk of early respiratory infections

Finnish researchers found that differences in maternal and infant gut microbiota during the first weeks of life were linked to the risk of respiratory tract infections in the first six months. Specific bacteria, including butyrate producers and opportunistic pathogens, may shape early infection susceptibility.

21 Aug 2025

Improving COPD care by enhancing communication and education

Prioritizing communications between patients and health care providers and increasing patient education about chronic obstructive pulmonary disease (COPD) could help improve patient care, according to a new study.

21 Aug 2025

Try this when your doctor says ‘yes’ to a preventive test but insurance says ‘no’

Trying to figure out why her claim was denied took Anna Deutscher a lot of time and work.

21 Aug 2025

Doctor News and Research

Aficamten outperforms beta-blockers in treating patients with obstructive hypertrophic cardiomyopathy

Research finds no added benefit from routine CT imaging after left main coronary intervention

Triglyceride levels substantially reduced with olezarsen compared to placebo

Phase II trial finds zilebesiran lowers systolic blood pressure in patients with uncontrolled hypertension

Extended apixaban therapy lowers recurrent VTE in patients with provoked events and enduring risk factors

AMALFI trial finds small increase in AF diagnosis with mail-based ECG patch monitoring

Beta blockers reduce mortality and heart failure in MI patients with mildly reduced ejection fraction

Evidence-based calculator to guide hypertension treatment choices

Most Americans unaware that early prostate cancer shows no symptoms

Native Hawaiian and Pacific Islander people face highest stroke rates in the U.S.

Hormone therapy type may influence postmenopausal cognitive health

Can the gut microbiome adapt to protect the brain after stroke?

Most US neurologists prescribing multiple sclerosis drugs receive pharma industry payments

An insurer agreed to cover her surgery. A politician’s nudge got the bills paid.

Small peptide produced by gut bacteria identified as key factor in kidney fibrosis

Many people unaware that knee and groin pain could signal hip problems

As measles exploded, officials in Texas looked to CDC scientists. Under Trump, no one answered.

Gut bacteria in mothers and newborns may shape infants’ risk of early respiratory infections

Improving COPD care by enhancing communication and education

Try this when your doctor says ‘yes’ to a preventive test but insurance says ‘no’

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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