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Targeting Wnt signaling to solve the dental pulp challenge

Dental pulp regeneration remains a major clinical challenge. Researchers have discovered that SMAD7 directly forms a transcriptional complex with β-catenin in human dental pulp stem cells, activating Wnt signaling and promoting regenerative gene expression.

9 Mar 2026

New peptide fragments teach the gut to tolerate food

In little moments like when sipping coffee or licking an ice cream cone, it doesn't seem like your body is pulling off a biological miracle. But it is. That cookie is not you-yet when you put it in your mouth, your body is able to tolerate it and process it without any detriment to your health in a process called oral tolerance. How does the human body make that decision between tolerance and rejection?

9 Mar 2026

How somatic mutations shape disease and reveal new drug targets

Researchers reviewed how somatic mutations accumulate in normal and diseased tissues, showing that natural selection can expand clones that influence disease risk, tissue adaptation, or cellular resilience. The study proposes somatic genomics as a powerful strategy to uncover disease mechanisms and identify new therapeutic targets across multiple conditions.

8 Mar 2026

Scientists identify ANKIB1 as key regulator of innate immune signaling

Innate immune sensors – known as pattern recognition receptors (PRRs) – detect specific molecular components of bacterial or viral intruders.

6 Mar 2026

NIH grant supports research on immune-related receptor in neurons

Florida Atlantic University has received a $2.4 million grant from the National Institutes of Health to investigate how an immune-related receptor in neurons plays a fundamental role in brain function, behavior and psychiatric health.

6 Mar 2026

Disrupted iron levels after SARS-CoV-2 infection may trigger long COVID

Problems with iron levels in the blood and the body's ability to regulate this important nutrient as a result of SARS-CoV-2 infection could be a key trigger for long COVID, new research has discovered.

6 Mar 2026

TREM2 helps macrophages survive and repair radiation damaged skin

Recently, teams led by Prof. Yiming Zhang from Xinqiao Hospital, Army Medical University,Prof. Fazhi Qi from Zhongshan Hospital, Fudan University, and Prof. Junli Zhou from the Tenth Affiliated Hospital of Southern Medical University (Dongguan People's Hospital), focused on the regulatory mechanisms of macrophage function in radiation-induced skin injury and systematically elucidated the critical role of TREM2 in maintaining macrophage survival and promoting skin repair under radiation stress.

6 Mar 2026

Machine learning model may provide an earning warning of preeclampsia in late gestation

A machine-learning model developed by Weill Cornell Medicine investigators may provide clinicians with an early warning of a complication that can occur late in pregnancy.

6 Mar 2026

Adults' exposure to diverse microbes may worsen allergic conditions

The "hygiene hypothesis" suggests exposure to diverse types of microbes may protect against developing diseases caused by allergens, but a new Cornell University study in mice reveals that adults' exposure to diverse microbes and allergens may in fact worsen certain allergic conditions.

6 Mar 2026

Weekend lie-ins may boost insulin sensitivity, but too much may backfire

This study explores the relationship between sleep patterns and insulin sensitivity, emphasizing the impact of weekday sleep and weekend catch-up on metabolism.

6 Mar 2026

Higher pollen levels linked to lower exam scores

New research links pollen exposure to lower exam scores in Finnish students, highlighting its potential impact on academic performance and future opportunities.

6 Mar 2026

Drug combination shows greater weight loss while preserving muscle mass

A recent research study found that a combination of the GLP-1 receptor agonist semaglutide and bimagrumab, an antibody that blocks activin signaling pathways, results in greater weight loss while also preserving lean mass, such as skeletal muscle and connective tissue.

5 Mar 2026

Combination therapy can reduce harmful effects of senescent cells in diabetic kidney disease

Mayo Clinic researchers have identified a drug-and-supplement combination therapy that is capable of reducing the harmful effects of senescent cells – also known as "zombie cells" – in diabetic kidney disease.

5 Mar 2026

Researchers propose that Parkinson’s disease may start in the gut, not the brain

A perspective in The Journal of Clinical Investigation argues that environmental exposures may interact with the gut microbiome and intestinal barrier to trigger biological processes linked to Parkinson’s disease. The authors propose that cumulative environmental stressors can erode host resilience, promoting α-synuclein pathology, immune activation, and neurodegeneration.

5 Mar 2026