Monoclonal Antibody News and Research

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Monoclonal antibodies (MAbs) are produced from a single B cell clone and can bind to a single type of antigen binding site. MAbs are homogenous antibodies that cannot form lattices with monomeric proteins as they can bind to only a single epitope on the antigen. Developed in the 1970s, MAbs can be produced against any given substance. Thus they can be used to detect and purify any substance of interest. This has made MAbs a powerful tool of molecular biology, biochemistry, and medicine.

Study: Blocking IL1α protein decreases severity of inflammation in Crohn's disease

Investigators at the Case Western Reserve University School of Medicine discovered that blocking interleukin-1α (IL1α), a protein that controls inflammation in the gut, markedly decreases the severity of intestinal inflammation in a mouse model of Crohn's disease (CD).

17 Dec 2019

Immunotherapy: A promising new alternative to cancer therapies

Sophie Lucas, a researcher at the University of Louvain (UCLouvain) de Duve Institute, studies the immune responses that cancer patients can develop against their own tumor.

16 Dec 2019

Combination therapy is safe and effective for older patients diagnosed with acute lymphoblastic leukemia

A study led by The University of Texas MD Anderson Cancer Center showed that treatment combining lower doses of chemotherapy with the monoclonal antibody inotuzumab ozogamicin (INO), with or without the drug blinatumomab, is safe and effective in patients over 60 years of age who were newly diagnosed with a high-risk form of acute lymphoblastic leukemia (ALL) known as Philadelphia chromosome-negative ALL.

10 Dec 2019

Streamlining Immuno-Oncological Therapeutic Antibody Discovery

The growing trend of implementing immunotherapy into oncology has resulted in various new therapeutic cancer treatments utilizing antibodies.

From Sartorius 3 Dec 2019

Experimental therapies offer patients a greater chance of surviving Ebola virus disease

The investigational therapeutics mAb114 and REGN-EB3 offer patients a greater chance of surviving Ebola virus disease compared to the investigational treatment ZMapp, according to published results from a clinical trial conducted in the Democratic Republic of the Congo.

2 Dec 2019

Biosimilar for HER2+ breast cancer achieves similar overall response rate to reference drug

The trastuzumab biosimilar HLX02 achieved similar overall response rate to reference trastuzumab in women with human epidermal growth factor receptor 2-positive (HER2+) recurrent or previously untreated metastatic breast cancer, according to a large, randomized phase III study reported at the ESMO Asia 2019 Congress.

22 Nov 2019

Lonza launches new basal and feed medium to optimize protein production

Lonza has further expanded its cell culture media portfolio with the addition of the eCHO Basal Medium and Feed, which has been designed to optimize protein production by delivering a consistent yield and highly viable cells while keeping lactate levels to a minimum for optimal protein integrity.

From Lonza 14 Nov 2019

Understanding Monoclonal Antibody Unfolding and Aggregation

A therapeutic monoclonal antibody and its Fab and Fc fragments were recently investigated using differential scanning fluorimetry, temperature-ramped dynamic light scattering, and turbidity measurements.

From Waters | Wyatt Technology 8 Nov 2019

Atlantic Health System Cancer Care enrolling patients in five pancreatic cancer studies

November is National Pancreatic Cancer Awareness month. This year alone, more than 56,000 Americans will be diagnosed with pancreatic cancer. Pancreatic tumors are particularly aggressive and hard to treat "due to a mutational profile that makes it resistant to therapies that work better for other tumor types," explains Angela Alistar, MD, medical director of GI Oncology at Morristown Medical Center.

30 Oct 2019

BioStreamline project outcomes

CPI have reported successful outcomes the £11.

From Fluidic Sciences and Sphere Bio 16 Oct 2019

BioStreamline: Streamlining the development of next generation biotherapeutics

A collaboration to streamline the development of cost-effective next generation biotherapeutics will host a dissemination event at CPI.

From Fluidic Sciences and Sphere Bio 16 Oct 2019

Dupilumab provides clinical benefit to adolescents with moderate-to-severe atopic dermatitis

Results from a phase IIa open-label trial and a subsequent phase III open-label extension trial reinforce findings from an earlier short-term trial that adolescents with moderate-to-severe atopic dermatitis, or eczema, can experience significant improvements with dupilumab.

9 Oct 2019

Analyses of two clinical trials predict response to asthma drug by COPD patients

Chronic obstructive pulmonary disease, or COPD, is the third leading cause of death in the U.S., according to the American Lung Association.

30 Sep 2019

Lung cancer may soon be picked up by a blood test

A study presented at the ESMO Congress 2019 has revealed that a blood test may soon be able to pick up circulating tumor DNA to help avoid invasive tissue biopsies in lung cancer patients.

30 Sep 2019

Clinical trial to evaluate efficacy and safety of new treatment for giant cell arteritis

An international, multicenter phase II clinical trial is evaluating the efficacy and safety of mavrilimumab co-administered with a 26-week corticosteroid taper in patients with giant cell arteritis.

26 Sep 2019

Accelerating Nanobody Production using Polyclonal Anti-VHH Antibodies

In this interview, Dr. Dave Fancy, CEO of Jackson ImmunoResearch explains how anti-VHH antibodies can be used to produce nanobodies and VHH libraries.

From Jackson ImmunoResearch Laboratories, Inc. 12 Sep 2019

VUMC partners with Batavia to move promising Zika antibody therapy closer to the clinic

Researchers at Vanderbilt University Medical Center are partnering with the Dutch biopharmaceutical firm Batavia Biosciences and Nashville-based IDBiologics to bring to the clinic a highly potent Zika virus neutralizing antibody they isolated three years ago.

6 Sep 2019

UC San Diego researchers identify new therapeutic approach to kill cancer cells

Epithelial cancers, such as cancers of the lung and pancreas, use the ανβ3 molecule to gain drug resistance to standard cancer therapies and to become highly metastatic.

22 Aug 2019

Scientists step closer to an Ebola cure

The Ebola virus has killed thousands of people in Western Africa between 2014 and 2016. Recently, another outbreak in Congo emerged, killing roughly a thousand people. Now, scientists are a step closer to an Ebola cure, thanks to two new drugs that appear to be highly effective in treating people with the virus.

13 Aug 2019

Human apolipoprotein E promotes hepatitis B virus infection

Human apolipoprotein E (apoE) promotes hepatitis B virus (HBV) infection and production, according to a study published DATE in the open-access journal PLOS Pathogens by Luhua Qiao and Guangxiang (George) Luo of the University of Alabama at Birmingham School of Medicine.

From PLOS ONE 13 Aug 2019

Monoclonal Antibody News and Research

Further Reading

Study: Blocking IL1α protein decreases severity of inflammation in Crohn's disease

Immunotherapy: A promising new alternative to cancer therapies

Combination therapy is safe and effective for older patients diagnosed with acute lymphoblastic leukemia

Streamlining Immuno-Oncological Therapeutic Antibody Discovery

Experimental therapies offer patients a greater chance of surviving Ebola virus disease

Biosimilar for HER2+ breast cancer achieves similar overall response rate to reference drug

Lonza launches new basal and feed medium to optimize protein production

Understanding Monoclonal Antibody Unfolding and Aggregation

Atlantic Health System Cancer Care enrolling patients in five pancreatic cancer studies

BioStreamline project outcomes

BioStreamline: Streamlining the development of next generation biotherapeutics

Dupilumab provides clinical benefit to adolescents with moderate-to-severe atopic dermatitis

Analyses of two clinical trials predict response to asthma drug by COPD patients

Lung cancer may soon be picked up by a blood test

Clinical trial to evaluate efficacy and safety of new treatment for giant cell arteritis

Accelerating Nanobody Production using Polyclonal Anti-VHH Antibodies

VUMC partners with Batavia to move promising Zika antibody therapy closer to the clinic

UC San Diego researchers identify new therapeutic approach to kill cancer cells

Scientists step closer to an Ebola cure

Human apolipoprotein E promotes hepatitis B virus infection

Antibodies eBook

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