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New pretreatment method boosts islet transplant survival in diabetes

A pretreatment step could help transplanted pancreatic islets survive longer in patients with type 1 diabetes, according to a new preclinical study from Weill Cornell Medicine investigators. One combination of small molecules extended the cells' lives in female mice, and adding two molecules to the mixture boosted cell survival in male mice.

25 Jun 2025

Once-monthly obesity injection shows double-digit weight loss in major clinical trial

Researchers found that once-monthly maridebart cafraglutide led to substantial weight loss and improved glycemic control in adults with obesity, with or without diabetes, in a phase 2 randomized trial. The drug demonstrated an acceptable safety profile and supports further study in phase 3 trials.

24 Jun 2025

Newborns and Alzheimer's patients have elevated blood levels of phosphorylated tau

Newborn babies and patients with Alzheimer's disease share an unexpected biological trait: elevated levels of a well-known biomarker for Alzheimer's.

24 Jun 2025

New KRAS mutation discovery opens door to targeted colon cancer therapies

Scientists at Fox Chase Cancer Center have identified a mutation in a common oncogene - a gene that can cause cancer - that may play an important role in colon cancer. Researchers also showed how this mutation could be targeted therapeutically.

24 Jun 2025

Study identifies potential way to slow or block progression of age-related macular degeneration

A new study from Washington University School of Medicine in St. Louis identifies a possible way to slow or block progression of age-related macular degeneration, a leading cause of blindness in people over age 50.

24 Jun 2025

Diabetes drug semaglutide shows promise in reducing dementia risk

Researchers at the Case Western Reserve School of Medicine have found that semaglutide, a popular diabetes and weight-loss drug, may lower the risk of dementia in people with type 2 diabetes (T2D).

24 Jun 2025

Experimental drug promotes weight loss by heating fat instead of suppressing appetite

An article published in the journal Nature Metabolism presents an experimental drug that stimulates adipose tissue cells to produce heat through a process known as thermogenesis, thereby promoting weight loss.

24 Jun 2025

Protective gene variant slows Alzheimer’s by taming brain inflammation

A rare gene mutation that delays Alzheimer's disease does so by damping inflammatory signaling in brain-resident immune cells, according to a preclinical study led by investigators at Weill Cornell Medicine.

23 Jun 2025

New oral drug shows promise for type 2 diabetes and obesity without side effects

Lower blood sugar and increased fat burning – without negatively affecting appetite or muscle mass. These are some of the most promising effects of a new potential drug treatment for people with type 2 diabetes and obesity, according to a new study published in the journal Cell by researchers from Karolinska Institutet and Stockholm University.

23 Jun 2025

Common bacterium can turn everyday plastic waste into paracetamol

Paracetamol production could be revolutionized by the discovery that a common bacterium can turn everyday plastic waste into the painkiller, a study reveals.

23 Jun 2025

Researchers turn a deadly fungus into potent cancer-fighting compound

Penn-led researchers have turned a deadly fungus into a potent cancer-fighting compound. After isolating a new class of molecules from Aspergillus flavus, a toxic crop fungus linked to deaths in the excavations of ancient tombs, the researchers modified the chemicals and tested them against leukemia cells.

23 Jun 2025

Researchers use electric fields to identify aged cells

Researchers from Tokyo Metropolitan University have created a new way of telling "aged" human cells apart from younger ones using electric fields.

21 Jun 2025

New intercellular network found to drive liver fibrosis progression

Liver fibrosis, a pathological condition in which the liver becomes stiff and scarred, commonly develops in the progression of chronic liver diseases such as chronic hepatitis and metabolic dysfunction-associated steatohepatitis (MASH).

21 Jun 2025

Scientists identify novel combination therapy approach to treat pediatric acute myeloid leukemia

Scientists at St. Jude Children's Research Hospital and Dana-Farber Cancer Institute today report the identification of a novel combination therapy approach to treat pediatric acute myeloid leukemia (AML).

20 Jun 2025

Targeting IGF2BP1 offers a new approach to cancer therapy

The RNA-binding protein IGF2BP1 has emerged as a key regulator of cancer hallmarks, influencing tumor proliferation, metastasis, immune evasion, and resistance to cell death.

20 Jun 2025

Fibroblast Growth Factor 8 drives key processes in embryonic development

The role of Fibroblast Growth Factor 8 (FGF8) in embryonic development and organ formation is gaining increased recognition as scientists uncover its wide-ranging influence.

20 Jun 2025

New 3D immunohistochemistry method enhances deep tissue imaging

Three dimensional immunohistochemistry (3D-IHC) has transformed our ability to visualize the spatial arrangement of cells and molecules in intact tissues.

19 Jun 2025

Self-regulating mRNA medicineadjusts protein production based on disease-related signals

Researchers develop a self-regulating mRNA medicine that adjusts protein production based on disease-related signals.

19 Jun 2025

Fruit fly study reveals how muscle cells sculpt organs

A new study from scientists at the University of North Carolina at Chapel Hill reveals that the cells shaping our organs may be far more mobile and coordinated than once believed.

19 Jun 2025

New dual-adjuvant vaccine strategy offers hope in the fight against HIV

In the quest to develop an effective HIV vaccine, scientists from Scripps Research have made a significant leap forward. They found that a two-part delivery strategy can train the immune system to produce a stronger response to HIV, offering new hope in the fight against one of the world's most elusive viruses.

19 Jun 2025