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Researchers use CRISPR/Cas9 technique to turn off gene that regulates cholesterol levels in adult mice

Biomedical engineers at Duke University have used a CRISPR/Cas9 genetic engineering technique to turn off a gene that regulates cholesterol levels in adult mice, leading to reduced blood cholesterol levels and gene repression lasting for six months after a single treatment.

27 Apr 2018

Parkinson's disease pivotal trial treats first patient using focused ultrasound

The first patient in a multicenter pivotal trial using focused ultrasound to address the major motor symptoms of Parkinson's disease has been treated at Weill Cornell Medicine and NewYork-Presbyterian/Weill Cornell Medical Center in New York.

27 Apr 2018

Scripps researchers awarded two grants to support studies on cocaine, oxycodone addiction

Last year, more than 60,000 Americans died of an opioid overdose, and millions more struggled with opioid and cocaine addiction.

27 Apr 2018

New clinical trial shows safety and efficacy of second generation drug-eluting stents

Results of the PERSPECTIVE trial were presented today as late-breaking clinical science at the Society for Cardiovascular Angiography and Interventions 2018 Scientific Sessions.

26 Apr 2018

New review finds underrepresentation of obese patients in cancer clinical trials

Obesity is a risk factor for a number of cancer types and can influence cancer treatment outcomes. In 2014, cancer types associated with being overweight or obese represented about 40 percent of all cancers diagnosed in the United States.

25 Apr 2018

Bacteria enhance antifungal drug resistance in early childhood caries

Early childhood caries, a form of severe tooth decay affecting toddlers and preschoolers, can set children up for a lifetime of dental and health problems. The problem can be significant enough that surgery is the only effective way to treat it.

25 Apr 2018

Scientists discover culprit in reducing effectiveness of insulin

Scientists at Osaka University discovered that Stromal derived factor-1 (SDF-1) secreted from adipocytes reduced the effectiveness of insulin in adipocytes and decreased insulin-induced glucose uptake.

25 Apr 2018

New combination therapy could improve survival in children with high-risk neuroblastoma

Investigators at the Children's Center for Cancer and Blood Diseases at Children's Hospital Los Angeles provide preclinical evidence that the presence of tumor-associated macrophages--a type of immune cell--can negatively affect the response to chemotherapy against neuroblastoma.

25 Apr 2018

GPs must embrace digital technologies to make healthcare access easier for patients

Few now question that harnessing technology and digital innovation is critical to the future of the NHS. The model of booking a face-to-face appointment with your GP has barely changed since 1948 but the pressure on patients and doctors has changed beyond recognition.

24 Apr 2018

Researchers create new tool to measure patient uncertainty for predicting hospital readmissions

Patients come back to Emergency Rooms after initial discharge for many reasons, but Jefferson emergency medicine physician Kristin Rising saw a common theme during multiple prior interview-based studies: patients feel uncertain.

23 Apr 2018

Research offers new hope for healing wounds in patients with diabetes

One of the most frustrating and debilitating complications of diabetes is the development of wounds on the foot or lower leg. Once they form, they can persist for months, leading to painful and dangerous infections.

23 Apr 2018

Researchers develop new drug-testing platform for epilepsy

For more than a third of children living with epilepsy, the currently approved medications do not stop their seizures. This statistic has not changed for the past five decades, despite the development of many new anti-seizure drugs.

20 Apr 2018

NovaDigm Therapeutics initiates NDV-3A Phase 2a study for reduction of S. aureus in military trainees

NovaDigm Therapeutics, a company developing innovative immuno-therapeutics and preventative vaccines for fungal and bacterial infections, today announced the initiation of a Phase 2a study evaluating NDV-3A for the reduction of Staphylococcus aureus (S. aureus) colonization in a high-risk population of military trainees.

19 Apr 2018

Genetic make-up impacts long-term effectiveness of phobia treatment

Researchers have discovered that variations in the efficacy of psychological treatment for phobias are associated with the serotonin transporter gene.

19 Apr 2018

Environmental pollutants found to worsen rheumatoid arthritis

Scientists have uncovered a link between the risk of developing rheumatoid arthritis and environmental pollutants, such as cigarette smoke.

19 Apr 2018

Nanodisc-delivered cancer treatment helps eliminate tumors

In the wrestling match with cancer, chemoimmunotherapy is the new strong arm, and it is building muscle with a nanodisc disguised as "good cholesterol."

18 Apr 2018

Pepper plant metabolizes antibiotic in personal care products

It sometimes can be hard to find toothpastes, soaps and other toiletries without antibiotics. Their popularity has caused an increase in environmental levels of antimicrobial substances, such as triclocarban (TCC), which end up in the water and soil used to grow crops.

18 Apr 2018

New computational framework accurately predicts drug-drug and drug-food interactions

A Korean research team from KAIST developed a computational framework, DeepDDI, that accurately predicts and generates 86 types of drug-drug and drug-food interactions as outputs of human-readable sentences, which allows in-depth understanding of the drug-drug and drug-food interactions.

18 Apr 2018

Advanced flow chemistry modules enhance control of nanoprecipitation

Syrris, a world leader in chemistry product innovation, continues to support pioneering research into nanoparticle drug encapsulation, thanks to its award-winning Asia range of advanced flow chemistry modules.

From Syrris Ltd 18 Apr 2018

NSAIDs alone or with acetaminophen better than opioids at easing dental pain

Opioids are not among the most effective-or longest lasting- options available for relief from acute dental pain, a new examination of the results from more than 460 published studies has found.

17 Apr 2018

Efficacy News and Research

Researchers use CRISPR/Cas9 technique to turn off gene that regulates cholesterol levels in adult mice

Parkinson's disease pivotal trial treats first patient using focused ultrasound

Scripps researchers awarded two grants to support studies on cocaine, oxycodone addiction

New clinical trial shows safety and efficacy of second generation drug-eluting stents

New review finds underrepresentation of obese patients in cancer clinical trials

Bacteria enhance antifungal drug resistance in early childhood caries

Scientists discover culprit in reducing effectiveness of insulin

New combination therapy could improve survival in children with high-risk neuroblastoma

GPs must embrace digital technologies to make healthcare access easier for patients

Researchers create new tool to measure patient uncertainty for predicting hospital readmissions

Research offers new hope for healing wounds in patients with diabetes

Researchers develop new drug-testing platform for epilepsy

NovaDigm Therapeutics initiates NDV-3A Phase 2a study for reduction of S. aureus in military trainees

Genetic make-up impacts long-term effectiveness of phobia treatment

Environmental pollutants found to worsen rheumatoid arthritis

Nanodisc-delivered cancer treatment helps eliminate tumors

Pepper plant metabolizes antibiotic in personal care products

New computational framework accurately predicts drug-drug and drug-food interactions

Advanced flow chemistry modules enhance control of nanoprecipitation

NSAIDs alone or with acetaminophen better than opioids at easing dental pain

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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