Neurodegenerative Diseases News and Research

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Obesity and Alzheimer’s linked through early metabolic disruptions

By 2030, the population in the United States aged 65 and older is expected to reach 71 million or about 20% of Americans. This growth is likely to increase the burden of age-related diseases, particularly Alzheimer's disease (AD), affecting about 1 in 9 adults over 65.

5 May 2026

Molecular switch protein Ten4 guides neuron migration in the developing brain

During brain development, neurons can regulate their movement until they reach their final destination thanks to a "molecular switch" involving the protein Teneurin 4 (Ten4).

30 Apr 2026

Oxidative stress in aging brain inhibits essential enzymes

Researchers at the Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) in Jena found that oxidative stress in the aging brain inhibits the activity of deubiquitylases.

29 Apr 2026

Scientists uncover why brain damage continues after stroke

Every stroke begins with a sudden interruption of blood flow in the brain. But what happens afterward—why neurons continue to lose function and die over the following days—has remained one of the most important unanswered questions in neuroscience.

28 Apr 2026

Lipid pathways driving diabetes and heart disease risk in South Asians

Identifying lipid-linked genetic pathways in Asian Indians offers insights into diabetes and heart disease, crucial for developing ancestry-specific therapies.

28 Apr 2026

Scientists seek to reverse neurodegeneration by eliminating harmful RNA pollution

Researchers at University of California San Diego School of Medicine, the Salk Institute and Sanford Burnham Prebys have received a four-year, $13 million award from the California Institute for Regenerative Medicine (CIRM) to investigate how to reverse age-related neurodegeneration by eliminating what the researchers call "RNA pollution" in aging neurons.

27 Apr 2026

L-arginine stabilizes protein droplets and prevents harmful fibril formation

Protein droplets serve important biological functions within cells, but in neurodegenerative diseases like Alzheimer's, these liquid-like droplets can form solid-like clumps known as fibrils.

23 Apr 2026

New human cell model replicates key mechanisms of neurodegenerative diseases

Researchers at LMU have developed a human cell model that replicates key mechanisms of neurodegenerative diseases - with potential for novel therapies.

23 Apr 2026

Microglia actively shape glioblastoma growth and tumor spread

Glioblastoma, the most common and most aggressive brain tumor type in adults, remains difficult to treat because it can infiltrate surrounding brain tissue and spread far beyond the main tumor.

21 Apr 2026

Having more children associated with lower stroke risk for women

While some say having lots of kids can make you lose your faculties, a new study suggests otherwise.

20 Apr 2026

Proteomics and AI bring earlier risk prediction into sharper focus

This review examines how high-throughput proteomics is expanding precision medicine by improving biomarker discovery, disease prediction, and drug development. It also shows how AI is helping researchers interpret complex proteomic data while highlighting major barriers such as standardization, validation, and clinical translation.

19 Apr 2026

How the immune system may influence Alzheimer’s, Parkinson’s, and related diseases

This review argues that neurodegeneration is shaped not only by toxic protein buildup but also by immune signaling, with microglia and T cells able to either protect the brain or worsen damage depending on context. It also highlights aging, head injury, and viral infection as major forces that reshape CNS immunity and may influence disease progression and future treatment strategies.

16 Apr 2026

Study explains failure of cellular cleanup in neurodegenerative diseases

Inside every cell, a cleanup operation runs around the clock. Proteins are constantly damaged by wear and tear. Some can be repaired, while others must be dismantled and recycled.

15 Apr 2026

New collaboration targets muscle loss treatments for space missions

The Center for Myokine Convergence Research at Korea University College of Medicine (Director: Professor Hyeon Soo Kim, Department of Anatomy, Korea University College of Medicine) has signed a memorandum of understanding (MOU) with MFC to jointly develop therapeutics for muscle loss in astronauts.

10 Apr 2026

Study reveals lung-brain link between smoking and neurodegeneration

The correlation between smoking and neurodegeneration is well-documented, with one study from 2011 finding heavy smoking in midlife was associated with a greater than 100% increase in risk of dementia, Alzheimer's and vascular dementia more than two decades later.

8 Apr 2026

Study outlines principles for using CAR immunotherapies to treat neurodegenerative diseases

A UAB research team defines the criteria that CAR immunotherapies for neurodegenerative diseases must meet to advance both conceptually and in trials, which are still at a very preliminary stage, in a review study published in the journal Trends in Pharmacological Sciences.

8 Apr 2026

RNA barcoding maps neural connections with unprecedented resolution

By tagging neurons with molecular "barcodes," researchers mapped connections among thousands of neurons in the mouse brain with unprecedented speed and resolution.

7 Apr 2026

Hearing loss and sex shape dual-task outcomes in older adults with mild cognitive impairment

Cognitive and physical training can help older adults with mild cognitive impairment (MCI) maintain or improve their ability to move and think simultaneously, but hearing ability and sex influence outcomes, according to a new Concordia-led study.

7 Apr 2026

Gladstone investigator wins MIND Prize to decode hidden Alzheimer’s genetics

Gladstone Institutes investigator Ryan Corces, PhD, has been named a 2026 winner of the Pershing Square Foundation's MIND Prize, a prestigious award recognizing next-frontier thinkers who are uncovering a deeper understanding of the brain and cognition.

7 Apr 2026

Review identifies TREM-1 as key amplifier of inflammatory diseases

Published in Current Molecular Pharmacology, a comprehensive review by Eman R. Al Sawy and colleagues from Cairo University consolidates evidence on the triggering receptor expressed on myeloid cells-1 (TREM-1) as a central amplifier of inflammatory responses.

7 Apr 2026