Macrophage News and Research

RSS

A macrophage is a type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells.

Scientists identify Smurf1 protein that plays role in autophagy of TB bacteria

UT Southwestern Medical Center researchers have identified a protein that is central to the immune system's ability to recognize and destroy the bacterium responsible for the global tuberculosis (TB) epidemic.

12 Jan 2017

Targeting Legumain could be promising strategy for treatment of cancer

Legumain (LGMN), or asparaginyl endopeptidase, is a newly identified lysosomal cysteine protease.

3 Jan 2017

Scientists pinpoint specific molecular events that may cause allergic reactions to air pollution

Scientists at the Immunology Frontier Research Center at Osaka University, Japan have pinpointed a specific molecular events that could explain allergic reactions to air pollution.

22 Dec 2016

Researchers use DNA markers to differentiate harmless species from deadly bacteria

The virulent pathogen that causes the disease tularemia, or "rabbit fever," was weaponized during past world wars and is considered a potential bioweapon.

20 Dec 2016

Researchers pinpoint mechanism underlying astrocyte-mediated recovery of brain tissue after injury

A Kobe University research team has pinpointed the mechanism underlying astrocyte-mediated restoration of brain tissue after an injury. This could lead to new treatments that encourage regeneration by limiting damage to neurons incurred by reduced blood supply or trauma.

15 Dec 2016

ABIVAX reports preclinical data on first-in-class drug candidate for functional cure of HIV/AIDS patients

ABIVAX an innovative biotechnology company targeting the immune system to eliminate viral disease, announced today that the Company presented new preclinical data on ABX464, ABIVAX's first-in-class drug candidate for a functional cure of patients with HIV/AIDS, during this week's HIV DART scientific conference in Los Cabos, Mexico.

9 Dec 2016

Researchers create 2-for-1 vaccine that protects mice from MERS and rabies

In a new study, researchers have modified a rabies virus, so that it has a protein from the MERS virus; this altered virus works as a 2-for-1 vaccine that protects mice against both Middle East Respiratory Syndrome (MERS) and rabies.

7 Dec 2016

Research unlocks potential new therapies for inflammatory diseases

Macrophages are frontline cells in our immune system. They detect microbial invaders and also tissue injury and then mount an appropriate response needed to clear the infection and repair the damaged tissue.

5 Dec 2016

Reseachers identify cellular ‘off’ switch for inflammatory immune response in asthma attacks

Working with human immune cells in the laboratory, Johns Hopkins researchers report they have identified a critical cellular "off" switch for the inflammatory immune response that contributes to lung-constricting asthma attacks.

2 Dec 2016

Low-dose chemotherapy regimens may be more effective at treating certain breast and pancreatic cancer types

Conventional, high-dose chemotherapy treatments can cause the fibroblast cells surrounding tumors to secrete proteins that promote the tumors' recurrence in more aggressive forms, researchers at Taipei Medical University and the National Institute of Cancer Research in Taiwan and University of California, San Francisco, have discovered.

24 Nov 2016

Study uncovers mechanism that causes chemo resistance of pancreatic cancer cells

A pioneering University of Liverpool research team have published a study that identifies the mechanism in the human body that causes resistance of pancreatic cancer cells to chemotherapy.

21 Nov 2016

Würzburg researchers develop novel technique to provide new insight into Salmonella infection process

Technological advances are making the analysis of single bacterial infected human cells feasible, Würzburg researchers have used this technology to provide new insight into the Salmonella infection process.

18 Nov 2016

New research shows immune paralysis in sepsis patients can be reversed

Failure of the immune system during blood poisoning (sepsis) can be reversed by a specific sugar.

18 Nov 2016

Getting drugs to bugs in NTM lung infections: an interview with Dr Jakko van Ingen

The first thing that is important to stress is that this is an area that we actually know very little about. What we generally think, rather than know, is that NTM has a lot in common with pulmonary tuberculosis.

17 Nov 2016

UAB researchers show how aging and excess dietary fat lead to heart failure

In mouse experiments, University of Alabama at Birmingham researchers have shown how aging and excess dietary fat create signals that lead to heart failure after a heart attack.

17 Nov 2016

Research shows CRAC channel inhibitors decrease lesion size, brain hemorrhage, and neurological deficits in TBI model

Researchers from the San Francisco Veterans Affairs Medical Center and UCSF, and CalciMedica, Inc., are presenting a poster at the 46th annual Society for Neuroscience meeting in San Diego describing the use of calcium release-activated calcium (CRAC) channel inhibitors in traumatic brain injury (TBI).

16 Nov 2016

TSRI study suggests new approach to limit tumor growth by targeting immune system cells

A new study led by scientists at The Scripps Research Institute suggests there may be a way to limit tumor growth by targeting immune system cells called macrophages.

11 Nov 2016

Immune checkpoint cancer therapies may cause rare cardiac side effects linked to unexpected immune response

Combination therapy utilizing two approved immunotherapy drugs for cancer treatment may cause rare and sometimes fatal cardiac side effects linked to an unexpected immune response.

4 Nov 2016

TPU scientists developing bioactive coating for medical implants

A group of young scientists from Tomsk Polytechnic University are developing a bioactive coating for medical implants. Due to its properties, it will be able to "convince" the body not to reject the artificial bones and joints.

2 Nov 2016

Researchers identify possible trigger of chronic inflammation in people with diabetes

Inflammation is one of the main reasons why people with diabetes experience heart attacks, strokes, kidney problems and other, related complications. Now, in a surprise finding, researchers at Washington University School of Medicine in St. Louis have identified a possible trigger of chronic inflammation.