Laboratory News and Research

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Study provides new insights into brain signaling during sleep and wakefulness

An international team led by the University of Michigan has introduced new methods that reveal which regions of the brain were active throughout the day with single-cell resolution.

10 Dec 2025

Contraception and surgical sterilization associated with increased life expectancy

Blocking reproduction increases lifespan in both males and females of many different species, a new international University of Otago – Ōtākou Whakaihu Waka-led study has found.

10 Dec 2025

$Tec-Dara could represent a new standard of care for relapsed or refractory multiple myeloma$

Tec-Dara could represent a new standard of care for relapsed or refractory multiple myeloma

Patients with relapsed or refractory (R/R) multiple myeloma who received a combination of teclistamab, a bispecific monoclonal antibody, and daratumumab, a CD38-directed monoclonal antibody, were 83% more likely to be alive without disease progression compared with those who received standard second-line therapies at a median of nearly 35 months of follow-up, according to the results of a new trial presented at the 67th American Society of Hematology (ASH) Annual Meeting and Exposition.

10 Dec 2025

National study maps where food additives come from in children’s and adults’ diets

By analysing nationally representative diet data, researchers show that food additives rarely occur alone, with children and teenagers experiencing the highest exposure to complex additive mixtures largely driven by ultra-processed foods.

9 Dec 2025

Blinking suppression reveals how the brain filters speech in noisy environments

Blinking is a human reflex most often performed without thinking, like breathing. Although research on blinking is usually related to vision, a new Concordia study examines how blinking is connected to cognitive function such as filtering out background noise to focus on what someone is trying to say to us in a crowded room.

9 Dec 2025

Gut microbe metabolite TMA improves blood sugar by shutting down a key inflammatory switch

Researchers identified trimethylamine (TMA) as a gut microbe–derived metabolite that directly inhibits IRAK4 to reduce metabolic inflammation and improve glycaemic control in high-fat-diet-fed mice. Choline-driven increases in TMA production replicated these benefits, revealing a host–microbe signaling axis with therapeutic potential for obesity-associated insulin resistance.

9 Dec 2025

Small molecule discovery could open the door to new class of treatments for hard-to-treat cancers

Researchers at the UCLA Health Jonsson Comprehensive Cancer Center have identified a small molecule that can inhibit a cancer-driving protein long considered impossible to target with drugs - a discovery that could open the door to a new class of treatments for leukemia and other hard-to-treat cancers.

9 Dec 2025

Negative health impacts caused by 'forever chemicals' linked to billions in economic losses

The negative health impacts from contamination by so called "forever chemicals" in drinking water costs the contiguous U.S. at least $8 billion a year in social costs, a University of Arizona-led study has found.

9 Dec 2025

Highly sensitive CRISPR-based method designed to detect low-frequency cancer mutations

Liquid biopsy is increasingly recognized as a promising tool for cancer detection and treatment monitoring, yet its effectiveness is often limited by the extremely low levels of tumor-derived DNA circulating in the blood.

9 Dec 2025

New antibody shows ability to overcome treatment resistance in blood cancers and solid tumors

In a new preclinical study, researchers from The University of Texas MD Anderson Cancer Center developed an antibody therapy called 77A that showed an ability to overcome treatment resistance in blood cancers, such as myeloma and lymphoma, as well as solid tumors.

9 Dec 2025

Online reference library provides a more accurate picture of drug exposure

Doctors and researchers try to understand what medications a person has taken by asking patients directly or by looking at medical records. But this information is often incomplete.

9 Dec 2025

Early RSV infection turns maternal allergy into a powerful driver of childhood asthma

Early-life RSV infection and parental allergy interact to substantially increase childhood asthma risk, supported by population data from more than 1.5 million children and mechanistic mouse experiments. The study shows that viral infection reprograms neonatal immune responses by altering how maternally transferred allergen-specific antibodies are handled, driving long-term allergic airway disease.

8 Dec 2025

Powerful prognostic marker could enable early identification of high-risk cancer patients

Aggressive T-cell lymphoma is a rare and devastating form of blood cancer with a very low five-year survival rate.

8 Dec 2025

Older chemical libraries yield new leads for next-generation COVID-19 antivirals

SARS‑CoV‑2, the virus that causes COVID-19, continues to mutate, with some newer strains becoming less responsive to current antiviral treatments like Paxlovid.

8 Dec 2025

Study reveals new genetic insights into reticular pseudodrusen in people with AMD

A study funded in part by the National Institutes of Health (NIH) has revealed important insights into the genetics of deposits in the eye, known as reticular pseudodrusen (RPD), that are linked to greater risk of vision loss among people with age-related macular degeneration (AMD).

8 Dec 2025

Industrial and farm chemicals quietly alter the balance of gut microbes

This study systematically screened over 1,000 agricultural and industrial chemicals and found that many can inhibit human gut bacteria in vitro. Beyond antimicrobial effects, these chemicals act as selective pressures that can reshape microbial competition, tolerance mechanisms, and metabolic pathways.

8 Dec 2025

Insufficient sleep may decrease life expectancy

A good night's sleep is more than a luxury: New research from Oregon Health & Science University suggests that insufficient sleep may shorten your life.

8 Dec 2025

Simple blood and urine tests could spare febrile infants from more invasive procedures

New evidence from a six-country study led by the Montreal Children's Hospital and Children's National Hospital shows simple blood and urine tests could spare many young infants with fevers from more invasive procedures.

8 Dec 2025

JAX wins $30 million contract to create computational "digital twins" of the human heart

Developing new drugs is one of the riskiest and most expensive endeavors in science. Today, The Jackson Laboratory (JAX) announced a bold initiative to improve that trajectory, powered by an up to $30 million contract from the Advanced Research Projects Agency for Health (ARPA-H) Computational ADME-Tox and Physiology Analysis for Safer Therapeutics (CATALYST) program.

8 Dec 2025

A slow-growing, bone-covered, noncancerous mass named as ossifying spindled and epithelioid tumor

It's not often that a pathologist gets to make a diagnosis that works for the patient by preventing treatment from occurring.

8 Dec 2025

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Laboratory News and Research

Study provides new insights into brain signaling during sleep and wakefulness

Contraception and surgical sterilization associated with increased life expectancy

Tec-Dara could represent a new standard of care for relapsed or refractory multiple myeloma

National study maps where food additives come from in children’s and adults’ diets

Blinking suppression reveals how the brain filters speech in noisy environments

Gut microbe metabolite TMA improves blood sugar by shutting down a key inflammatory switch

Small molecule discovery could open the door to new class of treatments for hard-to-treat cancers

Negative health impacts caused by 'forever chemicals' linked to billions in economic losses

Highly sensitive CRISPR-based method designed to detect low-frequency cancer mutations

New antibody shows ability to overcome treatment resistance in blood cancers and solid tumors

Online reference library provides a more accurate picture of drug exposure

Early RSV infection turns maternal allergy into a powerful driver of childhood asthma

Powerful prognostic marker could enable early identification of high-risk cancer patients

Older chemical libraries yield new leads for next-generation COVID-19 antivirals

Study reveals new genetic insights into reticular pseudodrusen in people with AMD

Industrial and farm chemicals quietly alter the balance of gut microbes

Insufficient sleep may decrease life expectancy

Simple blood and urine tests could spare febrile infants from more invasive procedures

JAX wins $30 million contract to create computational "digital twins" of the human heart

A slow-growing, bone-covered, noncancerous mass named as ossifying spindled and epithelioid tumor

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