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Emerging therapies transform autoimmune hepatitis treatment approaches

Autoimmune hepatitis (AIH) is a chronic, progressive liver disease caused by immune system dysregulation that targets the liver. If untreated, AIH can lead to severe complications, including cirrhosis and liver failure.

6 Nov 2024

Review: The multifaceted roles of bilirubin in liver health and disease

Bilirubin, the byproduct of hemoprotein breakdown, particularly hemoglobin, is a critical marker in diagnosing, prognosing, and managing liver diseases.

6 Nov 2024

New study reveals how tumor cells evade the immune system

It is comparatively easy to tell a cell's state of health: On their surface, cells present fragments of almost all the proteins they contain inside.

6 Nov 2024

Study reveals low rates of palliative care for heart failure patients in the U.S.

A study by researchers at Saint Louis University shows that only one in eight patients with heart failure in the United States receive palliative care consultations within five years of diagnosis.

5 Nov 2024

Unexpected immunotherapy success in rare pancreatic cancer

A new case report was published in Oncotarget's Volume 15 on October 11, 2024, entitled "A case of adenosquamous pancreatic cancer with a KRAS G12C mutation with an exceptional response to immunotherapy"

4 Nov 2024

Researchers develop the first polymer-based therapeutic for Huntington’s disease

Breakthrough polymer-based therapy shows promise in reversing Huntington's disease symptoms by preventing toxic protein clumps and enhancing neuronal survival.

4 Nov 2024

Exercise temporarily improves muscle insulin resistance linked to genetic risk for type 2 diabetes

The study uncovers how acute exercise alleviates insulin resistance in TBC1D4 variant carriers, underscoring the need for personalized diabetes interventions.

4 Nov 2024

NCCN leaders collaborate to enhance cancer care in Vietnam

As part of ongoing work to define and advance high-quality cancer care globally, leaders from the National Comprehensive Cancer Network (NCCN) - an alliance of leading cancer centers in the United States - will be in Vietnam today to collaborate on improving cancer care standards throughout the country.

1 Nov 2024

New stent sensor developed to detect blockages early

Stents to treat various blockages in the human body can themselves become blocked, but a new sensor developed at the University of Michigan for stents that are used in the bile duct may one day help doctors detect and treat stent blockages early, helping keep patients healthier.

1 Nov 2024

Two topical treatments show similar benefits for photoaging of the hands

Topically applied products containing human platelet extract or vitamin C provide similar improvements in age spots (photoaging) of the hands, as reported in a clinical trial within the November issue of Plastic and Reconstructive Surgery, the official medical journal of the American Society of Plastic Surgeons.

1 Nov 2024

New therapeutic target overcomes ovarian cancer immunotherapy resistance

Researchers at the Icahn School of Medicine at Mount Sinai have discovered a way that ovarian cancer tumors manipulate their environment to resist immunotherapy and identified a drug target that could overcome that resistance.

1 Nov 2024

New research reveals how Hepatitis E virus can lead to kidney disease

The hepatitis E virus affects the liver. But infected liver cells secrete a viral protein that reacts with antibodies in the blood and may form complexes that can damage the filter structure of the kidneys, as researchers from the University of Zurich and the University Hospital Zurich have proven for the first time.

1 Nov 2024

Can a $10 billion climate bond address California’s water contamination problem?

When Cynthia Ruiz turns on her kitchen faucet, she hears a slight squeak before cloudy fluid bursts out of the spout. The water in her Central Valley town of East Orosi is clean enough most of the time to wash dishes, flush toilets, and take showers, but it's not safe to swallow. Drinking water is trucked in twice a month.

31 Oct 2024

Study compares metabolism of humantenirine in human, pig, and goat liver microsomes

Gelsemium elegans Benth (G. elegans) is a traditional medicinal plant; however, it is highly toxic, and toxicity varies significantly between species.

30 Oct 2024

New toolkit aims to help U.S. hospitals spot deadly viral hemorrhagic fevers faster and safer

Researchers develop a laboratory toolkit to assist frontline healthcare facilities or the care of patients with suspected viral hemorrhagic fevers.

30 Oct 2024

Ratiometric fluorescent probes for measuring active albumin in liver disease patients

Albumin is a major prognostic factor for patients with advanced liver disease, dependent on its concentration and biological activity.

29 Oct 2024

Enzyme from gut microbe shows promise in fighting childhood malnutrition

The study highlights FAAH's role in gut microbiota, showing its potential in improving growth and health in malnourished children through dietary intervention.

29 Oct 2024

Elucidating the mechanisms behind kidney development

To Alex Hughes, Assistant Professor in Bioengineering within Penn Engineering and in Cell and Developmental Biology within Penn Medicine, the kidney is a work of art. "I find the development of the kidney to be a really beautiful process," says Hughes.

28 Oct 2024

Link between inflammatory bowel disease and spondyloarthritis revealed

There is a strong connection between inflammatory bowel disease (IBD) and spondyloarthritis - a condition that causes pain and stiffness in the joints.

28 Oct 2024

Study finds pistachios might help guard against vision loss

A study finds that pistachio consumption significantly increases macular pigment optical density, potentially protecting against vision loss in healthy adults.

28 Oct 2024