Antigen News and Research

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Scientists redesign CAR-T cells to fight more than cancer

This review examines how CAR-T cell therapy is expanding beyond blood cancers into solid tumors, autoimmune diseases, chronic viral infections, and next-generation immune-cell platforms. It highlights promising engineering advances, including universal CAR-T cells, in vivo delivery, CAR-NK cells, and safety switches, while emphasizing unresolved challenges in durability, safety, scalability, and global access.

29 Apr 2026

NCCN publishes new patient guide for prostate cancer screening

The National Comprehensive Cancer Network® (NCCN®)-an alliance of leading cancer centers-has published a new book explaining the latest evidence and expert recommendations around prostate cancer screening.

28 Apr 2026

Lipid pathways driving diabetes and heart disease risk in South Asians

Identifying lipid-linked genetic pathways in Asian Indians offers insights into diabetes and heart disease, crucial for developing ancestry-specific therapies.

28 Apr 2026

Glycocalyx modification boosts immune cell targeting against B lymphoma

A new study published in Engineering provides mechanistic insights into live-cell glycocalyx engineering and supports the rational design of next-generation adoptive cell therapies (ACTs) against B lymphoma, addressing limitations such as high costs and restricted antigen specificity in current treatments.

25 Apr 2026

Bacterial vesicles emerge as powerful tools against antibiotic resistance

Antibiotic resistance is making bacterial infections harder to treat, demanding new therapeutic strategies. A new review highlights bacterial extracellular vesicles (BEVs) as promising nanoscale tools that can kill pathogens, block infection, enhance vaccines, and deliver drugs.

25 Apr 2026

Kenyan bat coronavirus uses human CEACAM6 to enter cells, raising spillover concerns

Researchers screened a phylogenetically diverse panel of alphacoronavirus spike proteins and found that a heart-nosed bat coronavirus from Kenya can use human CEACAM6 to enter cells.

23 Apr 2026

Innovative light probes allow real-time visualization of cellular processes

Fluorescent proteins have revolutionized science, enabling researchers to tag and visualize individual molecules in living cells, tissues, and animals.

23 Apr 2026

Prostate cancer overdiagnosis risk increases substantially in older men

Researchers at Queen Mary University of London have found that the likelihood of prostate cancer overdiagnosis – the detection of a cancer that would never have been diagnosed during a patient's lifetime but for PSA screening – is low in younger men but rises substantially with old age.

22 Apr 2026

CAR-PRISM trial reports promising results in high-risk smoldering multiple myeloma

Results of the single-center, phase 2 CAR-PRISM (PRecision Intervention Smoldering Myeloma) clinical trial, the first to investigate Chimeric Antigen Receptor (CAR) T-cell therapy in patients with high-risk smoldering multiple myeloma, showed that all 20 patients were negative for minimal residual disease (MRD) within two months of treatment and remained MRD-negative after a median of 15.3 months of follow-up, and none experienced high-grade side effects, according to results presented at the AACR Annual Meeting 2026, held April 17-22, in San Diego, Calif.

21 Apr 2026

Trial shows safety of novel KIR-CAR T therapy in solid tumors

An innovative type of CAR T cell therapy, called KIR-CAR, was shown to be safe, with increasing efficacy corresponding to higher doses of the investigational treatment in nine patients with advanced ovarian cancer, mesothelioma or cholangiocarcinoma (bile duct cancer), according to an early report from an ongoing Phase I dose-escalation clinical trial.

20 Apr 2026

Single CAR T infusion shows strong response in smoldering multiple myeloma patients

A single infusion of ciltacabtagene autoleucel (Carvykti) led to a 100% minimal residual disease (MRD)-negativity rate in patients with high-risk smoldering multiple myeloma, according to results from CAR-PRISM, a phase II clinical trial, presented at the American Association for Cancer Research (AACR) Annual Meeting 2026, held April 17-22.

20 Apr 2026

Targeting glutamine metabolism enhances CAR-macrophage cancer therapy

Tumor-associated macrophages (TAMs) within the tumor microenvironment (TME) exhibit significant metabolic dysregulation, which impairs their antitumor function.

20 Apr 2026

How the immune system may influence Alzheimer’s, Parkinson’s, and related diseases

This review argues that neurodegeneration is shaped not only by toxic protein buildup but also by immune signaling, with microglia and T cells able to either protect the brain or worsen damage depending on context. It also highlights aging, head injury, and viral infection as major forces that reshape CNS immunity and may influence disease progression and future treatment strategies.

16 Apr 2026

FDA clears investigational new drug application to test sCAR-T therapy for autoimmune conditions

Calibr-Skaggs Institute for Innovative Medicines, the drug discovery division of Scripps Research, announced today that the FDA has cleared their investigational new drug (IND) application to study switchable chimeric antigen receptor T cell (sCAR-T) therapy (CLBR001 + SWI019) in patients with autoimmune conditions.

10 Apr 2026

Large US study finds never-married adults face higher risk for most major cancers

A large US population-based study found that never-married adults had higher cancer incidence than ever-married adults across most cancer types, with the largest disparities seen in older adults and in Black men. The pattern was especially strong for HPV-related, tobacco-related, and several reproductive cancers, suggesting marital status may act as an important social marker of cancer risk.

9 Apr 2026

Study outlines principles for using CAR immunotherapies to treat neurodegenerative diseases

A UAB research team defines the criteria that CAR immunotherapies for neurodegenerative diseases must meet to advance both conceptually and in trials, which are still at a very preliminary stage, in a review study published in the journal Trends in Pharmacological Sciences.

8 Apr 2026

Future CAR therapy expands beyond T cells to treat diverse diseases

CAR-T therapy has transformed treatment for some blood cancers, with seven FDA-approved products and strong clinical responses in hematologic malignancies.

8 Apr 2026

High affinity for immune receptors predicts antibody drug associated anaphylaxis risk

Antibody therapeutics are laboratory-made proteins designed to work like the body's natural antibodies. They are widely used to treat diseases such as cancer by binding to specific targets, including cancer cells or inflammatory molecules.

8 Apr 2026

Metformin boosts an exercise-linked metabolite and may help control weight in prostate cancer patients

Metformin raised the exercise-linked metabolite Lac-Phe in prostate cancer patients across disease stages and treatment settings, while Lac-Phe itself did not predict anticancer response. Patients in the BIMET-1 metformin arm also showed better weight management during anti-androgen therapy, highlighting a possible metabolic benefit relevant to prostate cancer care.

7 Apr 2026

Novel screening method boosts early diagnosis of leprosy

A new blood test combined with a standardized questionnaire and artificial intelligence may transform the way leprosy is diagnosed in Brazil. Researchers at the University of São Paulo (USP) tested the new test in Brazil using blood samples collected during a COVID-19 population survey.

6 Apr 2026

Antigen News and Research

Scientists redesign CAR-T cells to fight more than cancer

NCCN publishes new patient guide for prostate cancer screening

Lipid pathways driving diabetes and heart disease risk in South Asians

Glycocalyx modification boosts immune cell targeting against B lymphoma

Bacterial vesicles emerge as powerful tools against antibiotic resistance

Kenyan bat coronavirus uses human CEACAM6 to enter cells, raising spillover concerns

Innovative light probes allow real-time visualization of cellular processes

Prostate cancer overdiagnosis risk increases substantially in older men

CAR-PRISM trial reports promising results in high-risk smoldering multiple myeloma

Trial shows safety of novel KIR-CAR T therapy in solid tumors

Single CAR T infusion shows strong response in smoldering multiple myeloma patients

Targeting glutamine metabolism enhances CAR-macrophage cancer therapy

How the immune system may influence Alzheimer’s, Parkinson’s, and related diseases

FDA clears investigational new drug application to test sCAR-T therapy for autoimmune conditions

Large US study finds never-married adults face higher risk for most major cancers

Study outlines principles for using CAR immunotherapies to treat neurodegenerative diseases

Future CAR therapy expands beyond T cells to treat diverse diseases

High affinity for immune receptors predicts antibody drug associated anaphylaxis risk

Metformin boosts an exercise-linked metabolite and may help control weight in prostate cancer patients

Novel screening method boosts early diagnosis of leprosy

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Latest eBooks

Editorial Focus eBook - Spatial and single-cell omics (1st edition)

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics